The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 799 32,799 SH   SOLE   32,799 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,995 56,008 SH   SOLE   56,008 0 0
ACCELERON PHARMA INC COM 00434H108 12,793 100,000 SH Put SOLE   100,000 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500 2,302 284,151 SH   SOLE   284,151 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 1,527 235,800 SH Call SOLE   235,800 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 1,941 300,000 SH   SOLE   300,000 0 0
ADICET BIO INC COM 007002108 2,449 174,277 SH   SOLE   174,277 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2,804 258,700 SH Call SOLE   258,700 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 486 44,800 SH Put SOLE   44,800 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 468 475,778 SH   SOLE   475,778 0 0
AGENUS INC COM NEW 00847G705 3,020 950,000 SH   SOLE   950,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 5,416 125,000 SH Call SOLE   125,000 0 0
ALBIREO PHARMA INC COM 01345P106 633 16,883 SH   SOLE   16,883 0 0
ALECTOR INC COM 014442107 870 57,500 SH   SOLE   57,500 0 0
ALLAKOS INC COM 01671P100 8,218 58,700 SH Call SOLE   58,700 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 6,499 50,000 SH Put SOLE   50,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 60 4,739 SH   SOLE   4,739 0 0
ALTIMMUNE INC COM NEW 02155H200 851 75,445 SH   SOLE   75,445 0 0
ANAPTYSBIO INC COM 032724106 2,149 100,000 SH   SOLE   100,000 0 0
ANAPTYSBIO INC COM 032724106 3,915 182,100 SH Call SOLE   182,100 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 2,232 545,884 SH   SOLE   545,884 0 0
APPLIED THERAPEUTICS INC COM 03828A101 726 33,002 SH   SOLE   33,002 0 0
APPLIED THERAPEUTICS INC COM 03828A101 4,402 200,000 SH Put SOLE   200,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 18 3,904 SH   SOLE   3,904 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 408 115,000 SH   SOLE   115,000 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 4,338 100,000 SH Put SOLE   100,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 532 20,500 SH Put SOLE   20,500 0 0
ARDELYX INC COM 039697107 7,476 1,155,436 SH   SOLE   1,155,436 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 3,265 42,500 SH Call SOLE   42,500 0 0
ARGENX SE SPONSORED ADR 04016X101 59,260 201,500 SH Put SOLE   201,500 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 41,044 440,100 SH Put SOLE   440,100 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 15,346 200,000 SH Put SOLE   200,000 0 0
ARVINAS INC COM 04335A105 8,493 100,000 SH Put SOLE   100,000 0 0
ARVINAS INC COM 04335A105 358 4,216 SH   SOLE   4,216 0 0
ARVINAS INC COM 04335A105 19,763 232,700 SH Call SOLE   232,700 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 8,456 50,700 SH Call SOLE   50,700 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 14,526 87,090 SH   SOLE   87,090 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 405 2,006,451 SH   SOLE   2,006,451 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 439 72,468 SH   SOLE   72,468 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 17,498 350,000 SH Call SOLE   350,000 0 0
ATYR PHARMA INC COM NEW 002120202 1,552 400,000 SH   SOLE   400,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,383 100,000 SH Call SOLE   100,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 366 54,694 SH   SOLE   54,694 0 0
BAUDAX BIO INC COM 07160F107 101 100,000 SH   SOLE   100,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 1 100 SH   SOLE   100 0 0
BCTG ACQUISITION CORP COM 05492W103 1,711 149,512 SH   SOLE   149,512 0 0
BEAM THERAPEUTICS INC COM 07373V105 18,858 231,000 SH Put SOLE   231,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 25,141 97,300 SH Put SOLE   97,300 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 1,765 500,000 SH   SOLE   500,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 306 100,000 SH   SOLE   100,000 0 0
BIOGEN INC COM 09062X103 88,148 360,000 SH Put SOLE   360,000 0 0
BIOGEN INC COM 09062X103 1,396 5,700 SH   SOLE   5,700 0 0
BIOGEN INC COM 09062X103 115,181 470,400 SH Call SOLE   470,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 10,208 119,100 SH Call SOLE   119,100 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 8,923 104,100 SH Put SOLE   104,100 0 0
BIONTECH SE SPONSORED ADS 09075V102 26,080 319,900 SH Put SOLE   319,900 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 6,930 150,000 SH Call SOLE   150,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 9,421 293,941 SH   SOLE   293,941 0 0
BLUEBIRD BIO INC COM 09609G100 12 281 SH   SOLE   281 0 0
BLUEBIRD BIO INC COM 09609G100 4,595 106,200 SH Call SOLE   106,200 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 13,457 120,000 SH Put SOLE   120,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 17,890 288,400 SH   SOLE   288,400 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 444 644,021 SH   SOLE   644,021 0 0
C4 THERAPEUTICS INC COM STK 12529R107 5,019 151,500 SH   SOLE   151,500 0 0
CARA THERAPEUTICS INC COM 140755109 4,565 301,700 SH Call SOLE   301,700 0 0
CARA THERAPEUTICS INC COM 140755109 4,137 273,524 SH   SOLE   273,524 0 0
CARDIFF ONCOLOGY INC COM 14147L108 7,517 417,900 SH Put SOLE   417,900 0 0
CASI PHARMACEUTICALS INC COM 14757U109 3,741 1,268,154 SH   SOLE   1,268,154 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 1,392 650,000 SH   SOLE   650,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 7,008 400,000 SH Call SOLE   400,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 23,915 1,364,990 SH   SOLE   1,364,990 0 0
CERECOR INC COM 15671L109 536 202,865 SH   SOLE   202,865 0 0
CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 4,236 400,000 SH   SOLE   400,000 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 1,041 219,109 SH   SOLE   219,109 0 0
CHEMOCENTRYX INC COM 16383L106 27,969 451,700 SH Put SOLE   451,700 0 0
CHEMOCENTRYX INC COM 16383L106 2 37 SH   SOLE   37 0 0
CHIASMA INC COM 16706W102 3,177 730,299 SH   SOLE   730,299 0 0
CHIMERIX INC COM 16934W106 5,953 1,232,513 SH   SOLE   1,232,513 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,121 650,000 SH Call SOLE   650,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,082 642,108 SH   SOLE   642,108 0 0
COGENT BIOSCIENCES INC COM 19240Q201 469 41,762 SH   SOLE   41,762 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 1,127 23,648 SH   SOLE   23,648 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 8,947 187,800 SH Call SOLE   187,800 0 0
COMPUGEN LTD ORD M25722105 6 500 SH Put SOLE   500 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 174 139,100 SH   SOLE   139,100 0 0
CORTEXYME INC COM 22053A107 776 28,000 SH Call SOLE   28,000 0 0
CORTEXYME INC COM 22053A107 4,722 170,000 SH Put SOLE   170,000 0 0
CORTEXYME INC COM 22053A107 361 13,000 SH   SOLE   13,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 17,654 115,300 SH Put SOLE   115,300 0 0
CRYOPORT INC COM PAR $0.001 229050307 10,970 250,000 SH Call SOLE   250,000 0 0
CRYOPORT INC COM PAR $0.001 229050307 2,195 50,000 SH Put SOLE   50,000 0 0
CRYOPORT INC COM PAR $0.001 229050307 1,004 22,900 SH   SOLE   22,900 0 0
CUREVAC N V COM N2451R105 21,175 261,200 SH Put SOLE   261,200 0 0
CURIS INC COM NEW 231269200 4,198 512,500 SH Call SOLE   512,500 0 0
CURIS INC COM NEW 231269200 12,899 1,575,000 SH   SOLE   1,575,000 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 3,057 391,450 SH   SOLE   391,450 0 0
CYTOKINETICS INC COM NEW 23282W605 3,116 150,000 SH Call SOLE   150,000 0 0
CYTOKINETICS INC COM NEW 23282W605 4,718 227,000 SH   SOLE   227,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 1,897 358,330 SH   SOLE   358,330 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 7,989 140,000 SH Call SOLE   140,000 0 0
DELCATH SYS INC COM NEW 24661P807 2,019 112,712 SH   SOLE   112,712 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 4,208 415,000 SH   SOLE   415,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 119 17,900 SH Call SOLE   17,900 0 0
FATE THERAPEUTICS INC COM 31189P102 3,500 38,500 SH Call SOLE   38,500 0 0
FATE THERAPEUTICS INC COM 31189P102 3,529 38,800 SH Put SOLE   38,800 0 0
FIBROGEN INC COM 31572Q808 9,343 251,900 SH Put SOLE   251,900 0 0
FIBROGEN INC COM 31572Q808 11,126 300,000 SH Call SOLE   300,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 3,028 85,900 SH Put SOLE   85,900 0 0
FS DEV CORP COM CL A 303020101 3,850 350,000 SH   SOLE   350,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 5,125 437,700 SH   SOLE   437,700 0 0
GAMIDA CELL LTD SHS M47364100 1,343 160,000 SH   SOLE   160,000 0 0
GILEAD SCIENCES INC COM 375558103 17,478 300,000 SH Call SOLE   300,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 91 2,100 SH Put SOLE   2,100 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 8,663 200,000 SH Call SOLE   200,000 0 0
GOSSAMER BIO INC COM 38341P102 10,138 1,048,383 SH   SOLE   1,048,383 0 0
GOSSAMER BIO INC COM 38341P102 3,688 381,300 SH Call SOLE   381,300 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,204 19,100 SH Put SOLE   19,100 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 0 8 SH   SOLE   8 0 0
HARROW HEALTH INC COM 415858109 2,117 308,607 SH   SOLE   308,607 0 0
HOMOLOGY MEDICINES INC COM 438083107 1,129 100,000 SH Put SOLE   100,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 71,485 977,200 SH Call SOLE   977,200 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 19,385 265,000 SH Put SOLE   265,000 0 0
I MAB SPONSORED ADS 44975P103 7,073 150,000 SH   SOLE   150,000 0 0
ICAD INC COM NEW 44934S206 2,576 195,137 SH   SOLE   195,137 0 0
IGM BIOSCIENCES INC COM 449585108 22,073 250,000 SH Put SOLE   250,000 0 0
IGM BIOSCIENCES INC COM 449585108 27 300 SH   SOLE   300 0 0
IMMATICS N.V SHS N44445109 6,885 638,094 SH   SOLE   638,094 0 0
IMMUNOVANT INC COM 45258J102 10,882 235,587 SH   SOLE   235,587 0 0
INFLARX NV COM N44821101 754 149,750 SH   SOLE   149,750 0 0
INHIBRX INC COM 45720L107 266 8,076 SH   SOLE   8,076 0 0
INMUNE BIO INC COM 45782T105 3,747 217,568 SH   SOLE   217,568 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 8,934 280,989 SH   SOLE   280,989 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,180 100,000 SH Put SOLE   100,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 1,846 58,000 SH Call SOLE   58,000 0 0
INVENTIVA SA ADS 46124U107 214 15,000 SH   SOLE   15,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 16,397 290,000 SH Call SOLE   290,000 0 0
KADMON HLDGS INC COM 48283N106 3,887 936,615 SH   SOLE   936,615 0 0
KALA PHARMACEUTICALS INC COM 483119103 594 87,813 SH   SOLE   87,813 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,761 145,500 SH Call SOLE   145,500 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 20,204 1,063,961 SH   SOLE   1,063,961 0 0
KARUNA THERAPEUTICS INC COM 48576A100 12,192 120,000 SH Call SOLE   120,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 12 791 SH   SOLE   791 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 1,789 101,273 SH   SOLE   101,273 0 0
KINNATE BIOPHARMA INC COM 49705R105 79 2,000 SH   SOLE   2,000 0 0
KURA ONCOLOGY INC COM 50127T109 9,309 285,000 SH Call SOLE   285,000 0 0
KURA ONCOLOGY INC COM 50127T109 366 11,203 SH   SOLE   11,203 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 5,363 505,000 SH   SOLE   505,000 0 0
LILLY ELI & CO COM 532457108 16,884 100,000 SH Call SOLE   100,000 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 2,807 951,400 SH   SOLE   951,400 0 0
LONGVIEW ACQUISITION CORP COM CL A 543195101 1,243 62,796 SH   SOLE   62,796 0 0
LYRA THERAPEUTICS INC COM 55234L105 9,295 815,364 SH   SOLE   815,364 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 2,630 23,654 SH   SOLE   23,654 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 416 1,146,308 SH   SOLE   1,146,308 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,820 106,000 SH   SOLE   106,000 0 0
MERUS N V COM N5749R100 9,411 536,921 SH   SOLE   536,921 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 12,305 1,836,545 SH   SOLE   1,836,545 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 289 135,193 SH   SOLE   135,193 0 0
MIRATI THERAPEUTICS INC COM 60468T105 10,981 50,000 SH Call SOLE   50,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 781 3,557 SH   SOLE   3,557 0 0
MODERNA INC COM 60770K107 151,482 1,450,000 SH Put SOLE   1,450,000 0 0
MODERNA INC COM 60770K107 6,483 62,059 SH   SOLE   62,059 0 0
MORPHIC HLDG INC COM 61775R105 17,338 516,763 SH   SOLE   516,763 0 0
MUSTANG BIO INC COM 62818Q104 1,991 526,003 SH   SOLE   526,003 0 0
NEKTAR THERAPEUTICS COM 640268108 2,550 150,000 SH Call SOLE   150,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 2,272 23,700 SH Call SOLE   23,700 0 0
NEXTCURE INC COM 65343E108 2,179 200,000 SH   SOLE   200,000 0 0
NOVAVAX INC COM NEW 670002401 294 2,636 SH   SOLE   2,636 0 0
NOVAVAX INC COM NEW 670002401 36,097 323,700 SH Put SOLE   323,700 0 0
OCULAR THERAPEUTIX INC COM 67576A100 14,171 684,573 SH   SOLE   684,573 0 0
OCULAR THERAPEUTIX INC COM 67576A100 6,461 312,100 SH Call SOLE   312,100 0 0
ONCTERNAL THERAPEUTICS INC COM 68236P107 5,048 1,030,323 SH   SOLE   1,030,323 0 0
OTONOMY INC COM 68906L105 1,678 259,337 SH   SOLE   259,337 0 0
PANACEA ACQUISITION CORP CL A 698102100 2,361 201,808 SH   SOLE   201,808 0 0
PASSAGE BIO INC COM 702712100 3,495 136,697 SH   SOLE   136,697 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 3,321 100,000 SH   SOLE   100,000 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 2,752 250,837 SH   SOLE   250,837 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 275 5,000 SH   SOLE   5,000 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 15,725 649,542 SH   SOLE   649,542 0 0
PROTHENA CORP PLC SHS G72800108 14,252 1,186,700 SH   SOLE   1,186,700 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 563 54,901 SH   SOLE   54,901 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 1,026 100,000 SH Call SOLE   100,000 0 0
QUIDEL CORP COM 74838J101 4,545 25,300 SH Call SOLE   25,300 0 0
RAPT THERAPEUTICS INC COM 75382E109 69 3,500 SH Call SOLE   3,500 0 0
RAPT THERAPEUTICS INC COM 75382E109 309 15,600 SH Put SOLE   15,600 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 20,596 166,600 SH Put SOLE   166,600 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,209 345,529 SH   SOLE   345,529 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 75 1,400 SH   SOLE   1,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,069 81,700 SH Call SOLE   81,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,723 66,151 SH   SOLE   66,151 0 0
SAREPTA THERAPEUTICS INC COM 803607100 148,481 870,900 SH Put SOLE   870,900 0 0
SAREPTA THERAPEUTICS INC COM 803607100 85,416 501,000 SH Call SOLE   501,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 5,680 117,059 SH   SOLE   117,059 0 0
SCPHARMACEUTICALS INC COM 810648105 7,756 1,466,147 SH   SOLE   1,466,147 0 0
SERES THERAPEUTICS INC COM 81750R102 8,357 341,100 SH Call SOLE   341,100 0 0
SHATTUCK LABS INC COM 82024L103 3,406 65,000 SH   SOLE   65,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 5,111 318,890 SH   SOLE   318,890 0 0
SOCIAL CAP HEDSPIA HLDG CO I COM CL A G8251K107 1,677 100,000 SH   SOLE   100,000 0 0
SOCIAL CAP HEDSPIA HLDG CO I COM CL A G8251K107 2,516 150,000 SH Call SOLE   150,000 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 236 122,462 SH   SOLE   122,462 0 0
SOLID BIOSCIENCES INC COM 83422E105 5,973 788,008 SH   SOLE   788,008 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 89,731 240,000 SH Put SOLE   240,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 127,843 908,100 SH Put SOLE   908,100 0 0
SPDR SER TR S&P BIOTECH 78464A870 9,855 70,000 SH Call SOLE   70,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 57 37,597 SH   SOLE   37,597 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 5,929 2,440,028 SH   SOLE   2,440,028 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328874 398 200,000 SH   SOLE   200,000 0 0
SUTRO BIOPHARMA INC COM 869367102 13,360 615,360 SH   SOLE   615,360 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,224 100,000 SH Call SOLE   100,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 3,134 140,913 SH   SOLE   140,913 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 1,085 100,000 SH   SOLE   100,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 3,757 121,486 SH   SOLE   121,486 0 0
TG THERAPEUTICS INC COM 88322Q108 5,202 100,000 SH Put SOLE   100,000 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 31,787 2,716,840 SH   SOLE   2,716,840 0 0
TRANSLATE BIO INC COM 89374L104 67 3,600 SH Put SOLE   3,600 0 0
TRICIDA INC COM 89610F101 6,055 858,908 SH   SOLE   858,908 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2,942 200,000 SH Call SOLE   200,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 10,520 69,300 SH Call SOLE   69,300 0 0
VAXCYTE INC COM 92243G108 7,336 276,110 SH   SOLE   276,110 0 0
VERASTEM INC COM 92337C104 4,802 2,254,591 SH   SOLE   2,254,591 0 0
VINCERA PHARMA INC COM 92731L106 11,265 538,684 SH   SOLE   538,684 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 7,176 268,000 SH Put SOLE   268,000 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 8,703 4,485,952 SH   SOLE   4,485,952 0 0
X4 PHARMACEUTICALS INC COM 98420X103 5,314 826,424 SH   SOLE   826,424 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,432 223,173 SH   SOLE   223,173 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 2,253 132,514 SH   SOLE   132,514 0 0
ZOGENIX INC COM NEW 98978L204 3,480 174,091 SH   SOLE   174,091 0 0
ZOGENIX INC COM NEW 98978L204 17,342 867,400 SH Call SOLE   867,400 0 0
ZYMEWORKS INC COM 98985W102 27,422 580,200 SH Put SOLE   580,200 0 0
ZYMEWORKS INC COM 98985W102 17,732 375,200 SH Call SOLE   375,200 0 0
ZYMEWORKS INC COM 98985W102 73 1,556 SH   SOLE   1,556 0 0