The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADAPTIMMUNE THERAPEUTICS PLC | ADR | 00653A107 | 92,075 | 17,082,611 | SH | DFND | 17,082,611 | 0 | 0 | ||
| AFFIMED NV | COM | N01045108 | 35,656 | 6,126,488 | SH | DFND | 6,126,488 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 837 | 452,167 | SH | DFND | 452,167 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 85,239 | 4,298,488 | SH | DFND | 4,298,488 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 303,059 | 2,164,704 | SH | DFND | 2,164,704 | 0 | 0 | ||
| ANNEXON INC | COM | 03589W102 | 62,516 | 2,497,661 | SH | DFND | 2,497,661 | 0 | 0 | ||
| ARDELYX INC | COM | 039697107 | 88,209 | 13,633,582 | SH | DFND | 13,633,582 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 71,538 | 5,172,683 | SH | DFND | 5,172,683 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588307 | 22,809 | 3,952,958 | SH | DFND | 3,952,958 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 110,568 | 3,449,845 | SH | DFND | 3,449,845 | 0 | 0 | ||
| BLOOM ENERGY CORP | COM CL A | 093712107 | 38,213 | 1,333,333 | SH | DFND | 1,333,333 | 0 | 0 | ||
| CASPER SLEEP INC | COM | 147626105 | 38,291 | 6,226,130 | SH | DFND | 6,226,130 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 18,491 | 1,713,720 | SH | DFND | 1,713,720 | 0 | 0 | ||
| CLOUDFLARE INC | CL A COM | 18915M107 | 211,971 | 2,763,583 | SH | DFND | 2,763,583 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 243,445 | 1,590,002 | SH | DFND | 1,590,002 | 0 | 0 | ||
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 22,992 | 7,140,450 | SH | DFND | 7,140,450 | 0 | 0 | ||
| DESKTOP METAL INC | COM CL A | 25058X105 | 488,757 | 28,416,088 | SH | DFND | 28,416,088 | 0 | 0 | ||
| DZS INC | COM | 268211109 | 14,793 | 956,255 | SH | DFND | 956,255 | 0 | 0 | ||
| EARGO INC | COM | 270087109 | 292,269 | 6,520,948 | SH | DFND | 6,520,948 | 0 | 0 | ||
| ERYTECH PHARMA SA | ADR | 29604W108 | 5,769 | 625,000 | SH | DFND | 625,000 | 0 | 0 | ||
| GALERA THERAPEUTICS INC | COM | 36338D108 | 44,633 | 4,362,986 | SH | DFND | 4,362,986 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | COM | 372427401 | 25,112 | 10,376,936 | SH | DFND | 10,376,936 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 21,404 | 13,461,538 | SH | DFND | 13,461,538 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 34,175 | 9,089,041 | SH | DFND | 9,089,041 | 0 | 0 | ||
| IMARA INC | COM | 45249V107 | 88,579 | 4,017,170 | SH | DFND | 4,017,170 | 0 | 0 | ||
| INOZYME PHARMA INC | COM | 45790W108 | 50,452 | 2,444,379 | SH | DFND | 2,444,379 | 0 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 15,104 | 1,041,666 | SH | DFND | 1,041,666 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 8,147 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| LIQUIDIA TECHNOLOGIES INC | COM | 53635D202 | 7,334 | 2,486,062 | SH | DFND | 2,486,062 | 0 | 0 | ||
| LUMOS PHARMA INC | COM | 55028X109 | 18,807 | 526,663 | SH | DFND | 526,663 | 0 | 0 | ||
| MARKER THERAPEUTICS INC | COM | 57055L107 | 7,250 | 5,000,000 | SH | DFND | 5,000,000 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 22,527 | 8,533,072 | SH | DFND | 8,533,072 | 0 | 0 | ||
| METACRINE INC | COM | 59101E103 | 24,075 | 3,062,977 | SH | DFND | 3,062,977 | 0 | 0 | ||
| MILLENDO THERAPEUTICS INC | COM | 60040X103 | 3,781 | 1,766,779 | SH | DFND | 1,766,779 | 0 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 73,119 | 4,187,801 | SH | DFND | 4,187,801 | 0 | 0 | ||
| NKARTA INC | COM | 65487U108 | 178,569 | 2,904,974 | SH | DFND | 2,904,974 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 9,540 | 4,586,563 | SH | DFND | 4,586,563 | 0 | 0 | ||
| OPENDOOR TECHNOLOGIES INC | COM | 683712103 | 151,531 | 6,666,548 | SH | DFND | 6,666,548 | 0 | 0 | ||
| OYSTER PT PHARMA INC | COM | 69242L106 | 111,514 | 5,925,287 | SH | DFND | 5,925,287 | 0 | 0 | ||
| PALANTIR TECHNOLOGIES INC | CL A | 69608A108 | 1,413 | 59,980 | SH | DFND | 59,980 | 0 | 0 | ||
| PALO ALTO NETWORKS INC | COM | 697435105 | 95,488 | 268,684 | SH | DFND | 268,684 | 0 | 0 | ||
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 22,323 | 6,643,704 | SH | DFND | 6,643,704 | 0 | 0 | ||
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 8,709 | 6,451,056 | SH | DFND | 6,451,056 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 142,948 | 4,912,306 | SH | DFND | 4,912,306 | 0 | 0 | ||
| SENSEONICS HOLDINGS INC | COM | 81727U105 | 9,974 | 11,464,235 | SH | DFND | 11,464,235 | 0 | 0 | ||
| SPROUT SOCIAL INC | COM CL A | 85209W109 | 140,321 | 3,090,080 | SH | DFND | 3,090,080 | 0 | 0 | ||
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 10,063 | 4,141,308 | SH | DFND | 4,141,308 | 0 | 0 | ||
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 258 | 129,827 | SH | DFND | 129,827 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 9,135 | 4,229,410 | SH | DFND | 4,229,410 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H209 | 4,057 | 346,718 | SH | DFND | 346,718 | 0 | 0 | ||
| TREVENA INC | COM | 89532E109 | 8,157 | 3,811,691 | SH | DFND | 3,811,691 | 0 | 0 | ||
| TREVI THERAPEUTICS INC | COM | 89532M101 | 14,377 | 5,940,796 | SH | DFND | 5,940,796 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 84,382 | 5,736,363 | SH | DFND | 5,736,363 | 0 | 0 | ||
| UPSTART HLDGS INC | COM | 91680M107 | 23,357 | 573,184 | SH | DFND | 573,184 | 0 | 0 | ||
| VERONA PHARMA PLC | ADS | 925050106 | 35,760 | 5,108,563 | SH | DFND | 5,108,563 | 0 | 0 | ||
| VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 18,158 | 9,360,000 | SH | DFND | 9,360,000 | 0 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 15,259 | 992,107 | SH | DFND | 992,107 | 0 | 0 | ||