The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 13,470 2,499,025 SH   SOLE   2,499,025 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 103,006 9,502,383 SH   SOLE   9,502,383 0 0
AKOUOS INC COM 00973J101 45,237 2,281,249 SH   SOLE   2,281,249 0 0
ALECTOR INC COM 014442107 24,463 1,616,879 SH   SOLE   1,616,879 0 0
ARDELYX INC COM 039697107 39,875 6,163,086 SH   SOLE   6,163,086 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 32,777 1,165,184 SH   SOLE   1,165,184 0 0
ARVINAS INC COM 04335A105 311,937 3,672,872 SH   SOLE   3,672,872 0 0
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 10,850 1,000,000 SH   SOLE   1,000,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 978,221 5,865,338 SH   SOLE   5,865,338 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 224,294 5,368,451 SH   SOLE   5,368,451 0 0
AXSOME THERAPEUTICS INC COM 05464T104 134,869 1,655,447 SH   SOLE   1,655,447 0 0
BCTG ACQUISITION CORP COM 05492W103 14,300 1,250,000 SH   SOLE   1,250,000 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105 83,006 2,589,904 SH   SOLE   2,589,904 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 13,925 1,250,000 SH   SOLE   1,250,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 45,639 1,377,569 SH   SOLE   1,377,569 0 0
CHEMOCENTRYX INC COM 16383L106 295,764 4,776,548 SH   SOLE   4,776,548 0 0
CEREVEL THERAPEUTICS HLDNG INC COM 15678U128 36,476 2,200,000 SH   SOLE   2,200,000 0 0
CEREVEL THERAPEUTICS HLDNG INC *W EXP 06/09/2027 15678U102 1,318 233,333 SH   SOLE   233,333 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 23,049 1,823,520 SH   SOLE   1,823,520 0 0
CONSTELLATION PHARMCETICLS INC COM 210373106 53,359 1,852,746 SH   SOLE   1,852,746 0 0
COGENT BIOSCIENCES INC COM 19240Q201 11,518 1,025,641 SH   SOLE   1,025,641 0 0
CARDIFF ONCOLOGY INC COM 14147L108 59,187 3,290,000 SH   SOLE   3,290,000 0 0
CURIS INC COM NEW 231269200 63,127 7,707,790 SH   SOLE   7,707,790 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 7,959 564,102 SH   SOLE   564,102 0 0
DYNE THERAPEUTICS INC COM 26818M108 58,906 2,805,045 SH   SOLE   2,805,045 0 0
89BIO INC COM 282559103 115,422 4,736,214 SH   SOLE   4,736,214 0 0
FRAZIER LIFESCIENCES ACQUISITION CO UNIT 12/09/2025 G3710A121 10,380 1,000,000 SH   SOLE   1,000,000 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 314,507 9,011,651 SH   SOLE   9,011,651 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 72,891 4,285,161 SH   SOLE   4,285,161 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 7,628 750,000 SH   SOLE   750,000 0 0
GERON CORP COM 374163103 47,901 30,126,299 SH   SOLE   30,126,299 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 7,959 700,000 SH   SOLE   700,000 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 8,006 625,000 SH   SOLE   625,000 0 0
IGM BIOSCIENCES INC COM 449585108 86,765 982,723 SH   SOLE   982,723 0 0
IMARA INC COM 45249V107 5,486 248,804 SH   SOLE   248,804 0 0
IMMUNOGEN INC COM 45253H101 118,793 18,417,458 SH   SOLE   18,417,458 0 0
INHIBRX INC COM 45720L107 70,193 2,129,003 SH   SOLE   2,129,003 0 0
INOZYME PHARMA INC COM 45790W108 41,355 2,003,653 SH   SOLE   2,003,653 0 0
ITEOS THERAPEUTICS INC COM 46565G104 149,392 4,417,258 SH   SOLE   4,417,258 0 0
KALA PHARMACEUTICALS INC COM 483119103 73,730 10,874,613 SH   SOLE   10,874,613 0 0
KINNATE BIOPHARMA INC COM 49705R105 142,932 3,593,052 SH   SOLE   3,593,052 0 0
KEROS THERAPEUTICS INC COM 492327101 132,263 1,875,000 SH   SOLE   1,875,000 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 67,818 2,408,292 SH   SOLE   2,408,292 0 0
LYRA THERAPEUTICS INC COM 55234L105 9,301 815,849 SH   SOLE   815,849 0 0
LARIMAR THERAPEUTICS INC COM 517125100 32,439 1,515,151 SH   SOLE   1,515,151 0 0
MIRAGEN THERAPEUTICS INC COM NEW 60463E202 7,434 451,932 SH   SOLE   451,932 0 0
MACROGENICS INC COM 556099109 100,017 4,375,217 SH   SOLE   4,375,217 0 0
MILESTONE PHARMACEUTICALS INC COM 59935V107 15,596 2,327,714 SH   SOLE   2,327,714 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 15,860 1,300,000 SH   SOLE   1,300,000 0 0
NKARTA INC COM 65487U108 344,547 5,605,129 SH   SOLE   5,605,129 0 0
NOVAVAX INC COM NEW 670002401 422,463 3,788,564 SH   SOLE   3,788,564 0 0
OCULAR THERAPEUTIX INC COM 67576A100 15,525 750,000 SH   SOLE   750,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 103,391 2,150,404 SH   SOLE   2,150,404 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 19,768 584,000 SH   SOLE   584,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 41,155 12,315,213 SH   SOLE   12,315,213 0 0
OVID THERAPEUTICS INC COM 690469101 658 285,000 SH   SOLE   285,000 0 0
PACIFIC BIOSCIENCES OF CALIFORNIA INC COM 69404D108 51,569 1,987,997 SH   SOLE   1,987,997 0 0
PANDION THERAPEUTICS INC COM 698340106 26,285 1,770,023 SH   SOLE   1,770,023 0 0
PASSAGE BIO INC COM 702712100 8,250 322,630 SH   SOLE   322,630 0 0
VAXCYTE INC COM 92243G108 98,593 3,710,699 SH   SOLE   3,710,699 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 127,067 3,825,008 SH   SOLE   3,825,008 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 105,198 1,710,265 SH   SOLE   1,710,265 0 0
PROFOUND MEDICAL CORP COM NEW 74319B502 3,954 192,311 SH   SOLE   192,311 0 0
ROCKET PHARMACEUTICALS INC COM COM 77313F106 117,143 2,136,081 SH   SOLE   2,136,081 0 0
RELAY THERAPEUTICS INC COM 75943R102 41,560 1,000,000 SH   SOLE   1,000,000 0 0
REPARE THERAPEUTICS INC COM 760273102 14,029 409,000 SH   SOLE   409,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 124,244 4,179,067 SH   SOLE   4,179,067 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 80,733 1,742,186 SH   SOLE   1,742,186 0 0
SCPHARMACEUTICALS INC COM 810648105 18,615 3,518,998 SH   SOLE   3,518,998 0 0
SOLID BIOSCIENCES INC COM 83422E105 75,622 9,976,569 SH   SOLE   9,976,569 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 22,753 1,023,067 SH   SOLE   1,023,067 0 0
SUTRO BIOPHARMA INC COM 869367102 45,986 2,118,212 SH   SOLE   2,118,212 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 21,583 4,681,858 SH   SOLE   4,681,858 0 0
TG THERAPEUTICS INC COM 88322Q108 451,818 8,685,471 SH   SOLE   8,685,471 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 77,823 5,290,481 SH   SOLE   5,290,481 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 124,225 4,557,867 SH   SOLE   4,557,867 0 0
THERAPEUTICSMD INC COM 88338N107 9,453 7,812,500 SH   SOLE   7,812,500 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 31,824 5,100,000 SH   SOLE   5,100,000 0 0
VAXART INC COM NEW 92243A200 15,658 2,742,271 SH   SOLE   2,742,271 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 61,191 7,775,207 SH   SOLE   7,775,207 0 0
X4 PHARMACEUTICALS INC COM 98420X103 3,453 536,962 SH   SOLE   536,962 0 0
ZOGENIX INC COM NEW 98978L204 106,859 5,345,631 SH   SOLE   5,345,631 0 0