The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc CL A Common 88025U109 2,678 14,798 SH   SOLE   14,798 0 0
Aclaris Therapeutics, Inc. Common 00461U105 41,510 1,647,214 SH   SOLE   1,647,214 0 0
Akero Therapeutics Inc Common 00973Y108 19,532 673,280 SH   SOLE   673,280 0 0
Aligos Therapeutics Inc Common 01626L105 80,659 3,547,030 SH   SOLE   3,547,030 0 0
ALX Oncology Holdings Inc Common 00166B105 311,186 4,220,048 SH   SOLE   4,220,048 0 0
Amyris, Inc Common 03236M200 251,391 13,161,847 SH   SOLE   13,161,847 0 0
Arcutis Biotherapeutics Inc Common 03969K108 21,535 744,370 SH   SOLE   744,370 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 9,112 137,411 SH   SOLE   137,411 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 214,488 1,664,242 SH   SOLE   1,664,242 0 0
Aslan Pharmaceuticals Ltd ADS 04522R101 9,517 2,840,909 SH   SOLE   2,840,909 0 0
Atricure Inc Common 04963C209 4,231 64,573 SH   SOLE   64,573 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 6,502 500,732 SH   SOLE   500,732 0 0
Avadel Pharmaceuticals PLC ADR 05337M104 26,551 2,937,093 SH   SOLE   2,937,093 0 0
Bolt Therapeutics Inc Common 097702104 127,404 3,871,291 SH   SOLE   3,871,291 0 0
Calliditas Therapeutics ADR SPONSORED ADS 13124Q106 8,574 311,030 SH   SOLE   311,030 0 0
Celldex Therapeutics Inc Common 15117B202 26,613 1,291,875 SH   SOLE   1,291,875 0 0
Chinook Therapeutics Inc Common 16961L106 18,745 1,206,266 SH   SOLE   1,206,266 0 0
Codexis, Inc Common 192005106 8,885 388,144 SH   SOLE   388,144 0 0
Constellation Pharmaceutical Common 210373106 3,282 140,298 SH   SOLE   140,298 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 33,832 2,214,138 SH   SOLE   2,214,138 0 0
Cullinan Management Inc Common 230031106 10,418 250,000 SH   SOLE   250,000 0 0
Curis Inc Common 231269200 17,586 1,553,500 SH   SOLE   1,553,500 0 0
Cytokinetics Inc Common 23282W605 16,282 700,000 SH   SOLE   700,000 0 0
Design Therapeutics Common 25056L103 15,877 530,991 SH   SOLE   530,991 0 0
Dyne Therapeutics Inc Common 26818M108 8,971 577,642 SH   SOLE   577,642 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 15,853 1,791,257 SH   SOLE   1,791,257 0 0
Essa Pharma Inc Common 29668H708 60,102 2,068,907 SH   SOLE   2,068,907 0 0
Genetron Holdings Ltd ADS 37186H100 136,053 6,339,860 SH   SOLE   6,339,860 0 0
Gracell Biotechnologies Inc SPONSORED ADS 38406L103 23,454 1,522,994 SH   SOLE   1,522,994 0 0
Harmony Biosciences Holdings Inc Common 413197104 149,815 4,534,341 SH   SOLE   4,534,341 0 0
Homology Medicines, Inc. Common 438083107 8,028 853,143 SH   SOLE   853,143 0 0
IGM Biosciences Inc Common 449585108 1,534 20,000 SH   SOLE   20,000 0 0
Immunovant Inc Common 45258J102 8,547 532,847 SH   SOLE   532,847 0 0
Instil Bio Inc Common 45783C101 313,169 12,486,787 SH   SOLE   12,486,787 0 0
Iveric Bio Inc Common 46583P102 36,873 5,966,527 SH   SOLE   5,966,527 0 0
Kadmon Holdings Inc Common 48283N106 22,630 5,817,459 SH   SOLE   5,817,459 0 0
Kala Pharmaceuticals, Inc. Common 483119103 5,304 786,883 SH   SOLE   786,883 0 0
KalVista Pharmaceuticals Inc. Common 483497103 47,868 1,863,296 SH   SOLE   1,863,296 0 0
Kura Oncology Inc Common 50127T109 14,849 525,262 SH   SOLE   525,262 0 0
Larimar Therapeutics Inc Common 517125100 11,683 799,662 SH   SOLE   799,662 0 0
Legend Biotech Corp Sponsored SPONSORED ADS 52490G102 79,950 2,755,007 SH   SOLE   2,755,007 0 0
Mereo Biopharma Group PLC ADS 589492107 14,225 4,220,938 SH   SOLE   4,220,938 0 0
Merus NV Common N5749R100 3,656 175,000 SH   SOLE   175,000 0 0
Metacrine Inc Common 59101E103 908 146,426 SH   SOLE   146,426 0 0
New Frontier Health Corp Ord Shs G6461G106 161,590 14,300,000 SH   SOLE   14,300,000 0 0
Nkarta Inc Common 65487U108 16,852 512,225 SH   SOLE   512,225 0 0
Novavax Inc Common 670002401 28,554 157,487 SH   SOLE   157,487 0 0
Olema Pharmaceuticals Inc Common 68062P106 41,096 1,238,575 SH   SOLE   1,238,575 0 0
Orchard Therapeutics plc ADS 68570P101 9,625 1,325,736 SH   SOLE   1,325,736 0 0
Passage Bio Inc Common 702712100 24,708 1,413,508 SH   SOLE   1,413,508 0 0
Precision Biosciences Inc Common 74019P108 1,452 140,255 SH   SOLE   140,255 0 0
Satsuma Pharmaceuticals Inc Common 80405P107 7,283 1,232,394 SH   SOLE   1,232,394 0 0
Sierra Oncology, Inc Common 82640U404 33,031 1,917,074 SH   SOLE   1,917,074 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Syndax Pharmaceuticals Inc Common 87164F105 7,155 320,000 SH   SOLE   320,000 0 0
Tarsus Pharmaceuticals Inc Common 87650L103 104,587 3,245,035 SH   SOLE   3,245,035 0 0
Terns Pharmaceuticals Inc Common 880881107 58,853 2,675,133 SH   SOLE   2,675,133 0 0
Tricida, Inc. Common 89610F101 924 174,763 SH   SOLE   174,763 0 0
Verona Pharma PLC ADR ADS 925050106 25,486 3,048,507 SH   SOLE   3,048,507 0 0
VYNE Therapeutics Inc Common 92941V100 1,608 234,877 SH   SOLE   234,877 0 0
Zai Lab Ltd ADR ADR 98887Q104 23,350 175,000 SH   SOLE   175,000 0 0
Zogenix Inc Common 98978L204 2,050 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 9,034 286,064 SH   SOLE   286,064 0 0