The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 17,060 516,044 SH   SOLE   516,044 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100 9,036 375,256 SH   SOLE   375,256 0 0
ACCELERON PHARMA INC COM 00434H108 28,456 226,760 SH   SOLE   226,760 0 0
ACCOLADE INC COM 00437E102 13,346 245,741 SH   SOLE   245,741 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 7,395 755,375 SH   SOLE   755,375 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 14,926 850,000 SH   SOLE   850,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 14,416 352,804 SH   SOLE   352,804 0 0
ADMA BIOLOGICS INC COM 000899104 26,536 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 21,174 15,919,925 SH   SOLE   15,919,925 0 0
AKOYA BIOSCIENCES INC COM 00974H104 5,802 300,000 SH   SOLE   300,000 0 0
ALBIREO PHARMA INC COM 01345P106 83,030 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 112,211 9,903,879 SH   SOLE   9,903,879 0 0
ALPHA TEKNOVA INC COM 02080L102 712 30,000 SH   SOLE   30,000 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 27,579 1,800,180 SH   SOLE   1,800,180 0 0
AMERICAN WELL CORP CL A 03044L105 3,648 290,000 SH   SOLE   290,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 222,890 23,121,329 SH   SOLE   23,121,329 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 41,785 661,162 SH   SOLE   661,162 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 26,100 315,141 SH   SOLE   315,141 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 48,528 2,259,224 SH   SOLE   2,259,224 0 0
ATHENEX INC COM 04685N103 62,520 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 35,081 3,425,916 SH   SOLE   3,425,916 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 26,663 1,079,028 SH   SOLE   1,079,028 0 0
AXSOME THERAPEUTICS INC COM 05464T104 37,367 553,908 SH   SOLE   553,908 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 10,530 1,000,000 SH   SOLE   1,000,000 0 0
BCTG ACQUISITION CORP COM 05492W103 5,690 500,000 SH   SOLE   500,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 69,199 537,635 SH   SOLE   537,635 0 0
BIOATLA INC COM 09077B104 29,052 685,519 SH   SOLE   685,519 0 0
BRIDGEBIO PHARMA INC COM 10806X102 472,862 7,756,928 SH   SOLE   7,756,928 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110 1,127 233,333 SH   SOLE   233,333 0 0
C4 THERAPEUTICS INC COM STK 12529R107 85,464 2,258,566 SH   SOLE   2,258,566 0 0
CAREMAX INC COM CL A 14171W103 42,828 3,320,000 SH   SOLE   3,320,000 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 283 60,000 SH   SOLE   60,000 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 16,219 7,687,185 SH   SOLE   7,687,185 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 24,836 742,699 SH   SOLE   742,699 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 1,914 133,066 SH   SOLE   133,066 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 118,956 4,643,095 SH   SOLE   4,643,095 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 19,980 1,500,000 SH   SOLE   1,500,000 0 0
CM LIFE SCIENCES II INC UNIT 02/25/2028 125842203 16,813 1,250,000 SH   SOLE   1,250,000 0 0
CM LIFE SCIENCES III INC UNIT 04/30/2028 125841205 13,688 1,250,000 SH   SOLE   1,250,000 0 0
CM LIFE SCIENCES INC COM CL A 18978W109 3,180 227,000 SH   SOLE   227,000 0 0
CODEX DNA INC COM 192003101 9,350 425,000 SH   SOLE   425,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 25,861 3,188,750 SH   SOLE   3,188,750 0 0
COHERUS BIOSCIENCES INC COM 19249H103 64,968 4,697,612 SH   SOLE   4,697,612 0 0
COHERUS BIOSCIENCES INC NOTE 1.500% 4/1 19249HAB9 46,053 4,500,000 PRN   SOLE   4,500,000 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 23,126 978,277 SH   SOLE   978,277 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 189,723 17,500,000 PRN   SOLE   17,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 9,075 2,150,641 SH   SOLE   2,150,641 0 0
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 5,200 500,000 SH   SOLE   500,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 74,712 3,963,517 SH   SOLE   3,963,517 0 0
CVRX INC COM 126638105 12,320 440,000 SH   SOLE   440,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 10,387 1,640,957 SH   SOLE   1,640,957 0 0
DARIOHEALTH CORP COM NEW 23725P209 7,003 327,869 SH   SOLE   327,869 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 17,215 756,047 SH   SOLE   756,047 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 42,017 7,695,505 SH   SOLE   7,695,505 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 29,856 800,000 SH   SOLE   800,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,192 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 61,174 700,408 SH   SOLE   700,408 0 0
EXACT SCIENCES CORP COM 30063P105 29,029 233,523 SH   SOLE   233,523 0 0
FERRARI N V COM N3167Y103 1,278 6,200 SH   SOLE   6,200 0 0
FORTE BIOSCIENCES INC COM 34962G109 23,030 685,000 SH   SOLE   685,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 2,213 222,222 SH   SOLE   222,222 0 0
FULCRUM THERAPEUTICS INC COM 359616109 3,082 294,118 SH   SOLE   294,118 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 14,343 1,775,167 SH   SOLE   1,775,167 0 0
GALERA THERAPEUTICS INC COM 36338D108 2,503 254,664 SH   SOLE   254,664 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 145,427 4,152,689 SH   SOLE   4,152,689 0 0
GRAPHITE BIO INC COM 38870X104 26,892 875,093 SH   SOLE   875,093 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 13,870 491,332 SH   SOLE   491,332 0 0
HEALTH CATALYST INC COM 42225T107 31,423 566,084 SH   SOLE   566,084 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHRS G44125105 14,775 1,500,000 SH   SOLE   1,500,000 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 4,590 450,000 SH   SOLE   450,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 185,875 1,985,002 SH   SOLE   1,985,002 0 0
IMMATICS N.V SHS N44445109 29,025 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 15,620 400,000 SH   SOLE   400,000 0 0
INARI MED INC COM 45332Y109 28,958 310,437 SH   SOLE   310,437 0 0
INHIBRX INC COM 45720L107 24,963 907,090 SH   SOLE   907,090 0 0
INVITAE CORP COM 46185L103 162,538 4,818,801 SH   SOLE   4,818,801 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 285,173 10,959,772 SH   SOLE   10,959,772 0 0
IVERIC BIO INC COM 46583P102 28,935 4,585,512 SH   SOLE   4,585,512 0 0
KADMON HLDGS INC COM 48283N106 60,803 15,711,334 SH   SOLE   15,711,334 0 0
KODIAK SCIENCES INC COM 50015M109 26,602 286,041 SH   SOLE   286,041 0 0
KRONOS BIO INC COM 50107A104 60,547 2,528,052 SH   SOLE   2,528,052 0 0
LANDOS BIOPHARMA INC COM 515069102 171,747 14,869,915 SH   SOLE   14,869,915 0 0
LEAP THERAPEUTICS INC COM 52187K101 13,901 8,476,496 SH   SOLE   8,476,496 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 3,000 300,000 SH   SOLE   300,000 0 0
LONGVIEW ACQUISITION CORP II UNIT 99/99/9999 54319Q204 5,040 500,000 SH   SOLE   500,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 25,877 3,222,560 SH   SOLE   3,222,560 0 0
MACROGENICS INC COM 556099109 57,697 2,148,060 SH   SOLE   2,148,060 0 0
MEDTRONIC PLC SHS G5960L103 55,858 450,000 SH   SOLE   450,000 0 0
MEIRAGTX HLDGS PLC COM G59665102 107,698 6,948,277 SH   SOLE   6,948,277 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 5,377 1,696,068 SH   SOLE   1,696,068 0 0
MERUS NV COM N5749R100 3,687 175,000 SH   SOLE   175,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 514,618 3,185,898 SH   SOLE   3,185,898 0 0
MORPHIC HLDG INC COM 61775R105 53,840 938,140 SH   SOLE   938,140 0 0
MOTUS GI HLDGS INC COM 62014P108 1,873 1,800,542 SH   SOLE   1,800,542 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 14,604 1,059,800 SH   SOLE   1,059,800 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 16,194 1,000,000 PRN   SOLE   1,000,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 90,002 8,911,151 SH   SOLE   8,911,151 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 15,034 12,849,706 SH   SOLE   12,849,706 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 79,007 811,832 SH   SOLE   811,832 0 0
NEVRO CORP COM 64157F103 135,742 818,760 SH   SOLE   818,760 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 156,276 9,000,000 PRN   SOLE   9,000,000 0 0
NUVATION BIO INC COM CL A 67080N101 28,312 3,041,004 SH   SOLE   3,041,004 0 0
ONCORUS INC COM 68236R103 20,198 1,463,599 SH   SOLE   1,463,599 0 0
OUTSET MED INC COM 690145107 119,329 2,387,535 SH   SOLE   2,387,535 0 0
PHARVARIS NV COM N69605108 503 27,000 SH   SOLE   27,000 0 0
PLX PHARMA INC COM 72942A107 793 57,459 SH   SOLE   57,459 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 25,502 746,557 SH   SOLE   746,557 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 7,893 787,745 SH   SOLE   787,745 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 5,990 135,000 SH   SOLE   135,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 81,393 3,314,032 SH   SOLE   3,314,032 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 4,107 421,641 SH   SOLE   421,641 0 0
PROTHENA CORP PLC SHS G72800108 5,141 100,000 SH   SOLE   100,000 0 0
PROVENTION BIO INC COM 74374N102 7,996 948,481 SH   SOLE   948,481 0 0
QUOTIENT LTD SHS G73268107 58,971 16,200,818 SH   SOLE   16,200,818 0 0
RAIN THERAPEUTICS INC COM 75082Q105 39,425 2,537,019 SH   SOLE   2,537,019 0 0
RAPT THERAPEUTICS INC COM 75382E109 78,701 2,475,660 SH   SOLE   2,475,660 0 0
RAPT THERAPEUTICS INC COM 75382E109 83 45,000 SH Put SOLE   45,000 0 0
REGENXBIO INC COM 75901B107 3,469 89,283 SH   SOLE   89,283 0 0
RELAY THERAPEUTICS INC COM 75943R102 73,842 2,018,097 SH   SOLE   2,018,097 0 0
REPLIGEN CORP COM 759916109 26,450 132,500 SH   SOLE   132,500 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 10,140 1,000,000 SH   SOLE   1,000,000 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 384,422 45,000,000 PRN   SOLE   45,000,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 121,868 2,751,603 SH   SOLE   2,751,603 0 0
SC HEALTH CORP *W EXP 99/99/999 G78516401 1,055 500,000 SH   SOLE   500,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 1,298 66,655 SH   SOLE   66,655 0 0
SIGILON THERAPEUTICS INC COM 82657L107 1,341 125,000 SH   SOLE   125,000 0 0
SILK RD MED INC COM 82710M100 7,042 147,133 SH   SOLE   147,133 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 84,717 3,082,870 SH   SOLE   3,082,870 0 0
SOLID BIOSCIENCES INC COM 83422E105 49,090 13,412,552 SH   SOLE   13,412,552 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 399,681 4,849,912 SH   SOLE   4,849,912 0 0
STOKE THERAPEUTICS INC COM 86150R107 22,619 671,978 SH   SOLE   671,978 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 10,010 1,000,000 SH   SOLE   1,000,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 37,570 1,296,416 SH   SOLE   1,296,416 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 6,793 320,440 SH   SOLE   320,440 0 0
TCR2 THERAPEUTICS INC COM 87808K106 505 30,753 SH   SOLE   30,753 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 15,405 1,500,000 SH   SOLE   1,500,000 0 0
TELADOC HEALTH INC COM 87918A105 16,629 100,000 SH Call SOLE   100,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 26,927 1,845,555 SH   SOLE   1,845,555 0 0
TREACE MED CONCEPTS INC COM 89455T109 38,634 1,235,886 SH   SOLE   1,235,886 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 110,660 616,802 SH   SOLE   616,802 0 0
VBI VACCINES INC CDA COM NEW 91822J103 184,392 55,042,465 SH   SOLE   55,042,465 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 18,893 2,888,889 SH   SOLE   2,888,889 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 40,798 3,610,412 SH   SOLE   3,610,412 0 0
VERU INC COM 92536C103 35,922 4,451,342 SH   SOLE   4,451,342 0 0
VIATRIS INC COM 92556V106 14,353 1,004,419 SH   SOLE   1,004,419 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 14,531 794,506 SH   SOLE   794,506 0 0
VYNE THERAPEUTICS INC COM 92941V209 20,267 5,773,954 SH   SOLE   5,773,954 0 0
XENON PHARMACEUTICALS INC COM 98420N105 31,262 1,678,973 SH   SOLE   1,678,973 0 0
ZYMERGEN INC COM 98985X100 65,349 1,633,332 SH   SOLE   1,633,332 0 0
ZYMEWORKS INC COM 98985W102 149,361 4,305,600 SH   SOLE   4,305,600 0 0