The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 20,315 519,844 SH   SOLE   519,844 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100 19,298 444,878 SH   SOLE   444,878 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 36,386 1,410,305 SH   SOLE   1,410,305 0 0
ACCOLADE INC COM 00437E102 15,686 345,741 SH   SOLE   345,741 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 12,501 755,375 SH   SOLE   755,375 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 16,380 650,000 SH   SOLE   650,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 14,204 352,804 SH   SOLE   352,804 0 0
ADMA BIOLOGICS INC COM 000899104 29,189 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 33,113 15,919,925 SH   SOLE   15,919,925 0 0
ALBIREO PHARMA INC COM 01345P106 83,195 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 103,402 8,703,879 SH   SOLE   8,703,879 0 0
ALPHATEC HOLDINGS INC COM NEW 02081G201 25,490 1,800,180 SH   SOLE   1,800,180 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 40,376 1,143,790 SH   SOLE   1,143,790 0 0
AMERICAN WELL CORP CL A 03044L105 6,166 355,000 SH   SOLE   355,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 225,870 22,861,329 SH   SOLE   22,861,329 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 39,900 575,007 SH   SOLE   575,007 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 27,143 409,341 SH   SOLE   409,341 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 184,693 3,109,224 SH   SOLE   3,109,224 0 0
ATHENEX INC COM 04685N103 57,330 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 63,037 3,425,916 SH   SOLE   3,425,916 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 23,970 1,099,028 SH   SOLE   1,099,028 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 10,570 1,000,000 SH   SOLE   1,000,000 0 0
BCTG ACQUISITION CORP COM 05492W103 5,560 500,000 SH   SOLE   500,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 37,832 537,635 SH   SOLE   537,635 0 0
BIOGEN INC COM 09062X103 209,253 748,000 SH Call SOLE   748,000 0 0
BIOGEN INC COM 09062X103 167,850 600,000 SH Put SOLE   600,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 477,827 7,756,928 SH   SOLE   7,756,928 0 0
BUTTERFLY NETWORK INC *W EXP 05/27/202 124155110 1,505 233,333 SH   SOLE   233,333 0 0
C4 THERAPEUTICS INC COM STK 12529R107 116,835 3,158,566 SH   SOLE   3,158,566 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 5,588 1,933,551 SH   SOLE   1,933,551 0 0
CEL-SCI CORP COM PAR NEW 150837607 513 33,700 SH   SOLE   33,700 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 573 133,066 SH   SOLE   133,066 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 63,749 4,643,095 SH   SOLE   4,643,095 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 10,322 1,500,000 SH   SOLE   1,500,000 0 0
CM LIFE SCIENCES II INC UNIT 02/25/2028 125842203 16,000 1,250,000 SH   SOLE   1,250,000 0 0
CM LIFE SCIENCES INC COM CL A 18978W109 1,891 127,000 SH   SOLE   127,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 27,997 3,188,750 SH   SOLE   3,188,750 0 0
COHERUS BIOSCIENCES INC COM 19249H103 68,632 4,697,612 SH   SOLE   4,697,612 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 23,185 978,277 SH   SOLE   978,277 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 189,560 17,500,000 PRN   SOLE   17,500,000 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 29,360 797,404 SH   SOLE   797,404 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 10,731 2,150,641 SH   SOLE   2,150,641 0 0
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 4,880 500,000 SH   SOLE   500,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 51,606 3,659,381 SH   SOLE   3,659,381 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 16,650 2,153,974 SH   SOLE   2,153,974 0 0
DARIOHEALTH CORP COM NEW 23725P209 6,314 327,869 SH   SOLE   327,869 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 41,017 7,695,505 SH   SOLE   7,695,505 0 0
DEERFIELD HEALTHCARE TECH AC COM CL A 244413100 242 20,000 SH   SOLE   20,000 0 0
DEERFIELD HEALTHCARE TECH AC UNIT 07/16/2025 244413209 3,930 300,000 SH   SOLE   300,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 20,456 800,000 SH   SOLE   800,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,238 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 61,735 987,287 SH   SOLE   987,287 0 0
EXACT SCIENCES CORP COM 30063P105 46,587 353,523 SH   SOLE   353,523 0 0
FERRARI N V COM N3167Y103 1,298 6,200 SH   SOLE   6,200 0 0
FIBROGEN INC COM 31572Q808 6,942 200,000 SH Put SOLE   200,000 0 0
FORMA THERAPEUTICS HOLDINGS SHS 34633R104 35,025 1,250,000 SH   SOLE   1,250,000 0 0
FORTE BIOSCIENCES INC COM 34962G109 23,475 685,000 SH   SOLE   685,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 20,080 2,113,661 SH   SOLE   2,113,661 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 20,905 1,950,167 SH   SOLE   1,950,167 0 0
GALERA THERAPEUTICS INC COM 36338D108 2,246 254,664 SH   SOLE   254,664 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 206,139 5,058,642 SH   SOLE   5,058,642 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 10,298 311,673 SH   SOLE   311,673 0 0
HEALTH CATALYST INC COM 42225T107 23,670 506,084 SH   SOLE   506,084 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHRS G44125105 14,880 1,500,000 SH   SOLE   1,500,000 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,036 450,000 SH   SOLE   450,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 188,682 2,050,002 SH   SOLE   2,050,002 0 0
IMMATICS N.V SHS N44445109 28,025 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 17,028 400,000 SH   SOLE   400,000 0 0
INARI MED INC COM 45332Y109 60,467 565,113 SH   SOLE   565,113 0 0
INVITAE CORP COM 46185L103 204,831 5,360,673 SH   SOLE   5,360,673 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 273,915 8,651,785 SH   SOLE   8,651,785 0 0
IVERIC BIO INC COM 46583P102 28,338 4,585,512 SH   SOLE   4,585,512 0 0
KADMON HLDGS INC COM 48283N106 61,117 15,711,334 SH   SOLE   15,711,334 0 0
KODIAK SCIENCES INC COM 50015M109 44,110 389,008 SH   SOLE   389,008 0 0
KRONOS BIO INC COM 50107A104 79,671 2,780,097 SH   SOLE   2,780,097 0 0
LANDOS BIOPHARMA INC COM 515069102 140,967 14,869,915 SH   SOLE   14,869,915 0 0
LEAP THERAPEUTICS INC COM 52187K101 16,105 8,476,496 SH   SOLE   8,476,496 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 3,042 300,000 SH   SOLE   300,000 0 0
LONGVIEW ACQUISITION CORP II UNIT 99/99/9999 54319Q204 5,020 500,000 SH   SOLE   500,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 37,349 3,222,560 SH   SOLE   3,222,560 0 0
MACROGENICS INC COM 556099109 68,416 2,148,060 SH   SOLE   2,148,060 0 0
MEIRAGTX HLDGS PLC COM G59665102 93,374 6,933,277 SH   SOLE   6,933,277 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 20,220 6,000,000 SH   SOLE   6,000,000 0 0
MERUS N V COM N5749R100 3,655 175,000 SH   SOLE   175,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 595,183 3,474,505 SH   SOLE   3,474,505 0 0
MORPHIC HLDG INC COM 61775R105 59,365 938,140 SH   SOLE   938,140 0 0
MOTUS GI HLDGS INC COM 62014P108 2,070 1,800,542 SH   SOLE   1,800,542 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 15,939 1,059,800 SH   SOLE   1,059,800 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 16,555 12,849,706 SH   SOLE   12,849,706 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 91,593 941,832 SH   SOLE   941,832 0 0
NEVRO CORP COM 64157F103 113,295 812,154 SH   SOLE   812,154 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 135,324 9,000,000 PRN   SOLE   9,000,000 0 0
NUVATION BIO INC COM CL A 67080N101 29,041 3,041,004 SH   SOLE   3,041,004 0 0
ONCORUS INC COM 68236R103 27,700 1,989,987 SH   SOLE   1,989,987 0 0
OUTSET MED INC COM 690145107 129,858 2,387,535 SH   SOLE   2,387,535 0 0
PHARVARIS N V COM N69605108 755 27,000 SH   SOLE   27,000 0 0
PHREESIA INC COM 71944F106 5,210 100,000 SH   SOLE   100,000 0 0
PLX PHARMA INC COM 72942A107 2,006 222,180 SH   SOLE   222,180 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 24,554 746,557 SH   SOLE   746,557 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 7,523 787,745 SH   SOLE   787,745 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 55,354 3,314,032 SH   SOLE   3,314,032 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 6,637 421,642 SH   SOLE   421,642 0 0
PROVENTION BIO INC COM 74374N102 29,932 2,852,058 SH   SOLE   2,852,058 0 0
QUOTIENT LTD SHS G73268107 59,619 16,200,818 SH   SOLE   16,200,818 0 0
RAPT THERAPEUTICS INC COM 75382E109 55,000 2,477,481 SH   SOLE   2,477,481 0 0
REGENXBIO INC COM 75901B107 2,363 69,283 SH   SOLE   69,283 0 0
RELAY THERAPEUTICS INC COM 75943R102 69,766 2,018,097 SH   SOLE   2,018,097 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 10,250 1,000,000 SH   SOLE   1,000,000 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 474,750 45,000,000 PRN   SOLE   45,000,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 127,243 2,867,771 SH   SOLE   2,867,771 0 0
SANA BIOTECHNOLOGY INC COM 799566104 335 10,000 SH   SOLE   10,000 0 0
SC HEALTH CORP *W EXP 99/99/999 G78516401 945 500,000 SH   SOLE   500,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 1,148 66,655 SH   SOLE   66,655 0 0
SIGILON THERAPEUTICS INC COM 82657L107 2,794 125,000 SH   SOLE   125,000 0 0
SILK RD MED INC COM 82710M100 17,226 340,100 SH   SOLE   340,100 0 0
SOLID BIOSCIENCES INC COM 83422E105 74,171 13,412,552 SH   SOLE   13,412,552 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 356,808 4,849,912 SH   SOLE   4,849,912 0 0
STOKE THERAPEUTICS INC COM 86150R107 26,100 671,978 SH   SOLE   671,978 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,037 270,000 SH   SOLE   270,000 0 0
TALIS BIOMEDICAL CORP COM 87424L108 3,212 250,000 SH   SOLE   250,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 41,127 1,296,416 SH   SOLE   1,296,416 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 9,548 470,440 SH   SOLE   470,440 0 0
TCR2 THERAPEUTICS INC COM 87808K106 6,918 313,300 SH   SOLE   313,300 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 15,765 1,500,000 SH   SOLE   1,500,000 0 0
THERAPEUTICSMD INC COM 88338N107 3,685 2,750,000 SH   SOLE   2,750,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 82,362 3,298,419 SH   SOLE   3,298,419 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 29,272 175,000 SH   SOLE   175,000 0 0
VAXCYTE INC COM 92243G108 16,787 850,000 SH   SOLE   850,000 0 0
VBI VACCINES INC CDA COM NEW 91822J103 171,182 55,042,465 SH   SOLE   55,042,465 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 24,151 2,888,889 SH   SOLE   2,888,889 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 54,698 3,610,412 SH   SOLE   3,610,412 0 0
VERU INC COM 92536C103 47,963 4,451,342 SH   SOLE   4,451,342 0 0
VIATRIS INC COM 92556V106 14,032 1,004,419 SH   SOLE   1,004,419 0 0
VIEWRAY INC COM 92672L107 3,270 751,748 SH   SOLE   751,748 0 0
VINCERX PHARMA INC COM NEW 92731L106 5,790 300,000 SH   SOLE   300,000 0 0
VINCERX PHARMA INC *W EXP 12/24/202 92731L114 1,212 300,000 SH   SOLE   300,000 0 0
VYNE THERAPEUTICS INC COM 92941V209 46,368 6,773,954 SH   SOLE   6,773,954 0 0
XENON PHARMACEUTICALS INC COM 98420N105 9,219 515,042 SH   SOLE   515,042 0 0
ZYMEWORKS INC COM 98985W102 136,769 4,330,868 SH   SOLE   4,330,868 0 0