The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbCellera Biologics Inc. COM 00288U106 229,904 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,022,202 41,910,704 SH   SOLE   41,910,704 0 0
Acceleron Pharma Inc. COM 00434H108 2,815 22,430 SH   SOLE   22,430 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 25,369 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 41,880 9,830,877 SH   SOLE   9,830,877 0 0
ADC Therapeutics SA SHS H0036K147 34,531 1,418,107 SH   SOLE   1,418,107 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 23,734 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 32,614 1,428,571 SH   SOLE   1,428,571 0 0
Affimed N.V. COM N01045108 1,399 164,605 SH   SOLE   164,605 0 0
Akero Therapeutics, Inc. COM 00973Y108 2,937 118,378 SH   SOLE   118,378 0 0
Albireo Pharma, Inc. COM 01345P106 14,511 412,466 SH   SOLE   412,466 0 0
Alector, Inc. COM 014442107 4,983 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 32,820 1,610,000 SH   SOLE   1,610,000 0 0
Alkermes plc SHS G01767105 30,115 1,228,170 SH   SOLE   1,228,170 0 0
Allakos Inc. COM 01671P100 60,019 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 10,560 1,072,038 SH   SOLE   1,072,038 0 0
Amarin Corporation plc SPONSORED ADR 023111206 115,866 26,453,422 SH   SOLE   26,453,422 0 0
AnaptysBio, Inc. COM 032724106 11,077 427,179 SH   SOLE   427,179 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 143,585 2,271,917 SH   SOLE   2,271,917 0 0
argenx SE SPONSORED ADR 04016X101 337,065 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 465,723 3,540,270 SH   SOLE   3,540,270 0 0
Assembly Biosciences, Inc. COM 045396108 8,181 2,108,621 SH   SOLE   2,108,621 0 0
Athira Pharma, Inc. COM 04746L104 8,257 806,367 SH   SOLE   806,367 0 0
Atreca, Inc. CL A COM 04965G109 30,099 3,532,760 SH   SOLE   3,532,760 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 14,515 1,119,962 SH   SOLE   1,119,962 0 0
Axsome Therapeutics, Inc. COM 05464T104 36,365 539,057 SH   SOLE   539,057 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 4,004,649 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 822 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 34,964 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 200,958 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 633,251 7,589,294 SH   SOLE   7,589,294 0 0
Biomea Fusion, Inc. COM 09077A106 4,591 294,117 SH   SOLE   294,117 0 0
bluebird bio, Inc. COM 09609G100 7,259 226,988 SH   SOLE   226,988 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 6,161 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 5,473 636,363 SH   SOLE   636,363 0 0
Centessa Pharmaceuticals plc SPONSORED ADS 152309100 8,884 400,000 SH   SOLE   400,000 0 0
Cerus Corporation COM 157085101 81,045 13,713,195 SH   SOLE   13,713,195 0 0
Chiasma, Inc. COM 16706W102 6,720 1,420,740 SH   SOLE   1,420,740 0 0
Chinook Therapeutics, Inc. COM 16961L106 15,255 1,080,393 SH   SOLE   1,080,393 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 17,354 920,656 SH   SOLE   920,656 0 0
Cymabay Therapeutics, Inc. COM 23257D103 9,463 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 17,390 812,640 SH   SOLE   812,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 79,794 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 6,961 88,738 SH   SOLE   88,738 0 0
Design Therapeutics, Inc. COM 25056L103 28,575 1,436,636 SH   SOLE   1,436,636 0 0
Edgewise Therapeutics, Inc. COM 28036F105 10,665 500,000 SH   SOLE   500,000 0 0
Evofem Biosciences, Inc. COM 30048L104 3,048 2,697,110 SH   SOLE   2,697,110 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 50,399 2,024,876 SH   SOLE   2,024,876 0 0
Frequency Therapeutics, Inc. COM 35803L108 553 55,555 SH   SOLE   55,555 0 0
Fulgent Genetics, Inc. COM 359664109 36,986 401,016 SH   SOLE   401,016 0 0
Gamida Cell Ltd. SHS M47364100 3,914 610,626 SH   SOLE   610,626 0 0
Genetron Holdings Limited ADS 37186H100 9,170 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 112,675 3,217,441 SH   SOLE   3,217,441 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 3,489 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 126,204 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 6,416 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 56,101 599,110 SH   SOLE   599,110 0 0
IGM Biosciences, Inc. COM 449585108 262,588 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 49,725 4,282,938 SH   SOLE   4,282,938 0 0
Immunocore Holdings plc ADS 45258D105 98,435 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,693,988 32,021,732 SH   SOLE   32,021,732 0 0
Inozyme Pharma, Inc. COM 45790W108 1,823 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 61,360 2,156,001 SH   SOLE   2,156,001 0 0
Instil Bio, Inc. COM 45783C101 75,226 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 345,684 10,248,575 SH   SOLE   10,248,575 0 0
Iteos Therapeutics, Inc. COM 46565G104 3,856 150,346 SH   SOLE   150,346 0 0
IVERIC bio, Inc. COM 46583P102 8,872 1,406,037 SH   SOLE   1,406,037 0 0
Karuna Therapeutics, Inc. COM 48576A100 7,975 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 758 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 38,998 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 1,314,823 14,137,881 SH   SOLE   14,137,881 0 0
Krystal Biotech, Inc. COM 501147102 41,326 607,735 SH   SOLE   607,735 0 0
Kymera Therapeutics, Inc. COM 501575104 95,022 1,959,211 SH   SOLE   1,959,211 0 0
Leap Therapeutics, Inc. COM 52187K101 918 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 68,329 1,664,534 SH   SOLE   1,664,534 0 0
LogicBio Therapeutics, Inc. COM 54142F102 2,005 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 5,390 200,679 SH   SOLE   200,679 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 146,038 1,499,213 SH   SOLE   1,499,213 0 0
Mereo BioPharma Group plc ADS 589492107 7,796 2,459,399 SH   SOLE   2,459,399 0 0
Merus N.V. COM N5749R100 42,929 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 227,722 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 11,192 647,313 SH   SOLE   647,313 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 35,275 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 65,883 676,975 SH   SOLE   676,975 0 0
NexImmune, Inc. COM 65344D109 4,800 294,117 SH   SOLE   294,117 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 5,754 291,801 SH   SOLE   291,801 0 0
Novavax, Inc. COM 670002401 30,521 143,756 SH   SOLE   143,756 0 0
Nurix Therapeutics, Inc. COM 67080M103 65,107 2,454,082 SH   SOLE   2,454,082 0 0
Opthea Limited SPONSORED ADS 68386J208 27,092 3,412,062 SH   SOLE   3,412,062 0 0
Orchard Therapeutics plc ADS 68570P101 5,233 1,192,003 SH   SOLE   1,192,003 0 0
Otonomy, Inc. COM 68906L105 16,106 7,222,474 SH   SOLE   7,222,474 0 0
Oyster Point Pharma, Inc. COM 69242L106 1,056 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 111,973 3,201,972 SH   SOLE   3,201,972 0 0
Passage Bio, Inc. COM 702712100 1,551 117,161 SH   SOLE   117,161 0 0
Prelude Therapeutics Incorporated COM 74065P101 289,845 10,123,824 SH   SOLE   10,123,824 0 0
Protagonist Therapeutics, Inc. COM 74366E102 20,433 455,276 SH   SOLE   455,276 0 0
Protara Therapeutics, Inc. COM STK 74365U107 1,945 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 31,699 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 2,452 76,600 SH   SOLE   76,600 0 0
Replimune Group, Inc. COM 76029N106 5,898 153,512 SH   SOLE   153,512 0 0
Revolution Medicines, Inc. COM 76155X100 7,053 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 75,642 3,863,239 SH   SOLE   3,863,239 0 0
Seagen Inc. COM 81181C104 7,465,870 47,288,259 SH   SOLE   47,288,259 0 0
Silverback Therapeutics, Inc. COM 82835W108 7,355 238,095 SH   SOLE   238,095 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 357 65,497 SH   SOLE   65,497 0 0
Talis Biomedical Corporation COM 87424L108 83,550 7,574,835 SH   SOLE   7,574,835 0 0
TCR2 Therapeutics Inc. COM 87808K106 2,896 176,461 SH   SOLE   176,461 0 0
Travere Therapeutics, Inc. COM 89422G107 2,727 186,915 SH   SOLE   186,915 0 0
Tricida, Inc. COM 89610F101 3,151 729,300 SH   SOLE   729,300 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 42,378 444,444 SH   SOLE   444,444 0 0
Verastem, Inc. COM 92337C104 87,471 21,491,630 SH   SOLE   21,491,630 0 0
Verve Therapeutics, Inc. COM 92539P101 85,346 1,416,530 SH   SOLE   1,416,530 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 13,996 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 59,267 1,708,472 SH   SOLE   1,708,472 0 0
Apellis Pharmaceuticals, Inc. Note 3.5% 9/15/2026 03753UAB2 27,793 15,000,000 PRN   SOLE   15,000,000 0 0
BioMarin Pharmaceutical Inc. Note 0.599% 8/1/2024 09061GAH4 15,566 15,000,000 PRN   SOLE   15,000,000 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 44,063 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 13,890 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 38,479 29,174,000 PRN   SOLE   29,174,000 0 0
Tricida, Inc. Note 3.5% 5/15/2027 89610FAB7 27,332 75,000,000 PRN   SOLE   75,000,000 0 0