The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 2,178 116,452 SH   SOLE 116,452 0 0
ACCURAY INC COM 004397105 4,257 941,800 SH   SOLE 941,800 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 1,756 100,000 SH   SOLE 100,000 0 0
ADICET BIO INC COM 007002108 3,872 376,281 SH   SOLE 376,281 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 4,628 289,040 SH   SOLE 289,040 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,497 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 8,201 964,857 SH   SOLE 964,857 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,020 113,302 SH   SOLE 113,302 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 803 12,703 SH   SOLE 12,703 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,287 119,700 SH   SOLE 119,700 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 8,158 119,615 SH   SOLE 119,615 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 939 7,137 SH   SOLE 7,137 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,236 677,500 SH   SOLE 677,500 0 0
ATHIRA PHARMA INC COM 04746L104 1,648 160,983 SH   SOLE 160,983 0 0
ATRICURE INC COM 04963C209 7,261 91,529 SH   SOLE 91,529 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 9,135 94,100 SH   SOLE 94,100 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 18,288 207,911 SH   SOLE 207,911 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,546 100,000 SH   SOLE 100,000 0 0
BRAINWAY LTD SPONSORED ADS 10501L106 2,040 200,000 SH   SOLE 200,000 0 0
CARA THERAPEUTICS INC COM 140755109 4,495 315,000 SH   SOLE 315,000 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 6,385 149,700 SH   SOLE 149,700 0 0
CENTURY THERAPEUTICS INC COM 15673T100 2,347 80,000 SH   SOLE 80,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,813 223,554 SH   SOLE 223,554 0 0
COMPUGEN LTD ORD M25722105 1,668 201,502 SH   SOLE 201,502 0 0
CONFORMIS INC COM 20717E101 1,495 1,300,000 SH   SOLE 1,300,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 156 8,000 SH   SOLE 8,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,225 510,386 SH   SOLE 510,386 0 0
DEXCOM INC COM 252131107 9,026 21,138 SH   SOLE 21,138 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 19,061 510,756 SH   SOLE 510,756 0 0
FATE THERAPEUTICS INC COM 31189P102 27,283 314,360 SH   SOLE 314,360 0 0
FS DEVELOPMENT CORP II COM CL A 30318F100 2,994 300,000 SH   SOLE 300,000 0 0
F-STAR THERAPEUTICS INC COM 30315R107 6,136 714,285 SH   SOLE 714,285 0 0
GALAPAGOS NV SPON ADR 36315X101 5,351 77,675 SH   SOLE 77,675 0 0
GENFIT S A ADS 372279109 716 188,549 SH   SOLE 188,549 0 0
HARPOON THERAPEUTICS INC COM 41358P106 1,459 105,163 SH   SOLE 105,163 0 0
HOOKIPA PHARMA INC COM 43906K100 2,951 322,124 SH   SOLE 322,124 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 6,962 331,661 SH   SOLE 331,661 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,373 459,260 SH   SOLE 459,260 0 0
INFLARX NV COM N44821101 1,782 600,000 SH   SOLE 600,000 0 0
INOGEN INC COM 45780L104 978 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 6,693 40,900 SH   SOLE 40,900 0 0
IVERIC BIO INC COM 46583P102 1,135 179,951 SH   SOLE 179,951 0 0
KADMON HOLDINGS INC COM 48283N106 1,527 394,561 SH   SOLE 394,561 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,452 60,600 SH   SOLE 60,600 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,041 53,000 SH   SOLE 53,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,267 54,415 SH   SOLE 54,415 0 0
KURA ONCOLOGY INC COM 50127T109 1,742 83,529 SH   SOLE 83,529 0 0
LARIMAR THERAPEUTICS INC COM 517125100 756 76,987 SH   SOLE 76,987 0 0
LAVA THERAPEUTICS BV SHS N51517105 1,476 135,632 SH   SOLE 135,632 0 0
LUMINEX CORP COM 55027E102 5,119 139,091 SH   SOLE 139,091 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 545 5,600 SH   SOLE 5,600 0 0
MASIMO CORPORATION COM 574795100 727 3,000 SH   SOLE 3,000 0 0
MEI PHARMA INC COM NEW 55279B202 1,827 641,000 SH   SOLE 641,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 3,571 1,126,613 SH   SOLE 1,126,613 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,742 128,263 SH   SOLE 128,263 0 0
MERUS N V COM N5749R100 3,326 157,841 SH   SOLE 157,841 0 0
MORPHIC HOLDING INC COM 61775R105 10,414 181,467 SH   SOLE 181,467 0 0
NATUS MEDICAL INC COM 639050103 2,485 95,653 SH   SOLE 95,653 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,168 73,655 SH   SOLE 73,655 0 0
NEURONETICS INC COM 64131A105 4,065 253,717 SH   SOLE 253,717 0 0
NEXTCURE INC COM 65343E108 1,473 183,491 SH   SOLE 183,491 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 601 30,502 SH   SOLE 30,502 0 0
NURIX THERAPEUTICS INC COM 67080M103 8,127 306,320 SH   SOLE 306,320 0 0
OTONOMY INC COM 68906L105 5,306 2,379,392 SH   SOLE 2,379,392 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 2,243 603,042 SH   SOLE 603,042 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 6,955 1,031,880 SH   SOLE 1,031,880 0 0
RADIUS HEALTH INC COM NEW 750469207 264 14,500 SH   SOLE 14,500 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,711 4,000,000 PRN   SOLE 4,000,000 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 3,137 455,933 SH   SOLE 455,933 0 0
REVOLUTION MEDICINES INC COM 76155X100 6,657 209,731 SH   SOLE 209,731 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,059 244,000 SH   SOLE 244,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,675 170,306 SH   SOLE 170,306 0 0
SCPHARMACEUTICALS INC COM 810648105 238 38,891 SH   SOLE 38,891 0 0
STEREOTAXIS INC COM NEW 85916J409 131,881 13,680,554 SH   SOLE 13,680,554 0 0
SURGALIGN HOLDINGS INC COM 86882C105 806 579,710 SH   SOLE 579,710 0 0
SUTRO BIOPHARMA INC COM 869367102 1,580 85,000 SH   SOLE 85,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,536 147,702 SH   SOLE 147,702 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 10,634 732,345 SH   SOLE 732,345 0 0
TRANSLATE BIO INC COM 89374L104 10,382 376,993 SH   SOLE 376,993 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 3,733 47,852 SH   SOLE 47,852 0 0
VASCULAR BIOGENICS LTD COM M96883109 734 306,980 SH   SOLE 306,980 0 0
VENUS CONCEPT INC COM 92332W105 3,686 1,185,100 SH   SOLE 1,185,100 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,680 447,400 SH   SOLE 447,400 0 0
XENON PHARMACEUTICALS INC COM 98420N105 7,570 406,535 SH   SOLE 406,535 0 0