The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc CL A Common 88025U109 2,898 14,798 SH   SOLE   14,798 0 0
Aclaris Therapeutics, Inc. Common 00461U105 24,132 1,374,279 SH   SOLE   1,374,279 0 0
Aligos Therapeutics Inc Common 01626L105 72,306 3,547,030 SH   SOLE   3,547,030 0 0
ALX Oncology Holdings Inc Common 00166B105 230,752 4,220,048 SH   SOLE   4,220,048 0 0
Amyris, Inc Common 03236M200 190,546 11,639,929 SH   SOLE   11,639,929 0 0
Arcutis Biotherapeutics Inc Common 03969K108 11,833 433,585 SH   SOLE   433,585 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 11,380 137,411 SH   SOLE   137,411 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 200,793 1,526,359 SH   SOLE   1,526,359 0 0
Aslan Pharmaceuticals Ltd ADS 04522R101 9,375 2,840,909 SH   SOLE   2,840,909 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 6,489 500,732 SH   SOLE   500,732 0 0
Avadel Pharmaceuticals PLC ADR 05337M104 19,767 2,937,093 SH   SOLE   2,937,093 0 0
Bolt Therapeutics Inc Common 097702104 59,850 3,871,291 SH   SOLE   3,871,291 0 0
Calliditas Therapeutics ADR SPONSORED ADS 13124Q106 1,835 62,306 SH   SOLE   62,306 0 0
Celldex Therapeutics Inc Common 15117B202 32,400 968,906 SH   SOLE   968,906 0 0
Chinook Therapeutics Inc Common 16961L106 12,315 872,151 SH   SOLE   872,151 0 0
Codexis, Inc Common 192005106 8,795 388,144 SH   SOLE   388,144 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 33,032 1,752,346 SH   SOLE   1,752,346 0 0
Curis Inc Common 231269200 12,537 1,553,500 SH   SOLE   1,553,500 0 0
Cytokinetics Inc Common 23282W605 13,853 700,000 SH   SOLE   700,000 0 0
Design Therapeutics Common 25056L103 10,561 530,991 SH   SOLE   530,991 0 0
Dyne Therapeutics Inc Common 26818M108 12,154 577,642 SH   SOLE   577,642 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 15,262 1,791,257 SH   SOLE   1,791,257 0 0
Elevation Oncology Inc Common 28623U101 6,742 496,843 SH   SOLE   496,843 0 0
Essa Pharma Inc Common 29668H708 44,331 1,551,680 SH   SOLE   1,551,680 0 0
Genetron Holdings Ltd ADS 37186H100 127,685 6,339,860 SH   SOLE   6,339,860 0 0
Gracell Biotechnologies Inc SPONSORED ADS 38406L103 17,267 1,328,257 SH   SOLE   1,328,257 0 0
Harmony Biosciences Holdings Inc Common 413197104 128,004 4,534,341 SH   SOLE   4,534,341 0 0
Homology Medicines, Inc. Common 438083107 6,202 853,143 SH   SOLE   853,143 0 0
Immunovant Inc Common 45258J102 5,632 532,847 SH   SOLE   532,847 0 0
Impel NeuroPharma Inc Common 45258K109 25,530 2,884,789 SH   SOLE   2,884,789 0 0
Instil Bio Inc Common 45783C101 241,245 12,486,787 SH   SOLE   12,486,787 0 0
Iveric Bio Inc Common 46583P102 37,649 5,966,527 SH   SOLE   5,966,527 0 0
Kadmon Holdings Inc Common 48283N106 22,514 5,817,459 SH   SOLE   5,817,459 0 0
KalVista Pharmaceuticals Inc. Common 483497103 44,645 1,863,296 SH   SOLE   1,863,296 0 0
Kura Oncology Inc Common 50127T109 10,952 525,262 SH   SOLE   525,262 0 0
Larimar Therapeutics Inc Common 517125100 7,853 799,662 SH   SOLE   799,662 0 0
Legend Biotech Corp Sponsored SPONSORED ADS 52490G102 39,273 956,702 SH   SOLE   956,702 0 0
Mereo Biopharma Group PLC ADS 589492107 13,380 4,220,938 SH   SOLE   4,220,938 0 0
Merus NV Common N5749R100 9,313 442,000 SH   SOLE   442,000 0 0
Metacrine Inc Common 59101E103 556 146,426 SH   SOLE   146,426 0 0
New Frontier Health Corp Ord Shs G6461G106 159,731 14,300,000 SH   SOLE   14,300,000 0 0
Nkarta Inc Common 65487U108 16,232 512,225 SH   SOLE   512,225 0 0
Novavax Inc Common 670002401 18,693 88,046 SH   SOLE   88,046 0 0
Olema Pharmaceuticals Inc Common 68062P106 34,655 1,238,575 SH   SOLE   1,238,575 0 0
Orchard Therapeutics plc ADS 68570P101 5,820 1,325,736 SH   SOLE   1,325,736 0 0
Passage Bio Inc Common 702712100 8,553 646,001 SH   SOLE   646,001 0 0
Precision Biosciences Inc Common 74019P108 1,756 140,255 SH   SOLE   140,255 0 0
Satsuma Pharmaceuticals Inc Common 80405P107 8,688 1,232,394 SH   SOLE   1,232,394 0 0
Sierra Oncology, Inc Common 82640U404 37,325 1,917,074 SH   SOLE   1,917,074 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Syndax Pharmaceuticals Inc Common 87164F105 5,494 320,000 SH   SOLE   320,000 0 0
Tarsus Pharmaceuticals Inc Common 87650L103 86,573 2,987,331 SH   SOLE   2,987,331 0 0
Terns Pharmaceuticals Inc Common 880881107 32,797 2,675,133 SH   SOLE   2,675,133 0 0
Tricida, Inc. Common 89610F101 755 174,763 SH   SOLE   174,763 0 0
Valneva SE SPONSORED ADS 92025Y103 10,540 400,000 SH   SOLE   400,000 0 0
Verona Pharma PLC ADR ADS 925050106 19,937 3,048,507 SH   SOLE   3,048,507 0 0
Zai Lab Ltd ADR ADR 98887Q104 30,973 175,000 SH   SOLE   175,000 0 0
Zogenix Inc Common 98978L204 1,814 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 9,924 286,064 SH   SOLE   286,064 0 0