The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 12,669 70,000 SH Put SOLE   70,000 0 0
AC IMMUNE SA SHS H00263105 911 119,803 SH   SOLE   119,803 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 14,921 578,300 SH Put SOLE   578,300 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 155 6,008 SH   SOLE   6,008 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500 3,291 284,151 SH   SOLE   284,151 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 4,742 188,200 SH   SOLE   188,200 0 0
ADC THERAPEUTICS SA SHS H0036K147 7,323 300,000 SH Call SOLE   300,000 0 0
ADICET BIO INC COM 007002108 1,768 135,094 SH   SOLE   135,094 0 0
ADVISORSHARES TR PURE US CANNABIS 00768Y453 6,360 150,000 SH Call SOLE   150,000 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 3,420 2,651,093 SH   SOLE   2,651,093 0 0
AGENUS INC COM NEW 00847G705 1,847 678,843 SH   SOLE   678,843 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 6,456 125,000 SH Call SOLE   125,000 0 0
AILERON THERAPEUTICS INC COM 00887A105 4,004 2,800,000 SH   SOLE   2,800,000 0 0
ALBIREO PHARMA INC COM 01345P106 595 16,883 SH   SOLE   16,883 0 0
ALECTOR INC COM 014442107 5,185 257,500 SH   SOLE   257,500 0 0
ALLAKOS INC COM 01671P100 4,327 37,700 SH Put SOLE   37,700 0 0
ALLAKOS INC COM 01671P100 4,935 43,000 SH Call SOLE   43,000 0 0
ALLAKOS INC COM 01671P100 3,639 31,700 SH   SOLE   31,700 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 4,115 116,600 SH Call SOLE   116,600 0 0
ALLOVIR INC COM 019818103 4,680 200,000 SH Call SOLE   200,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 3,230 304,739 SH   SOLE   304,739 0 0
ALTIMMUNE INC COM NEW 02155H200 2,571 181,941 SH   SOLE   181,941 0 0
AMICUS THERAPEUTICS INC COM 03152W109 3,373 341,500 SH   SOLE   341,500 0 0
ANAPTYSBIO INC COM 032724106 207 9,553 SH   SOLE   9,553 0 0
ANAPTYSBIO INC COM 032724106 3,925 182,100 SH Call SOLE   182,100 0 0
ANNOVIS BIO INC COM 03615A108 5,395 193,368 SH   SOLE   193,368 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 2,108 415,884 SH   SOLE   415,884 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 622 103,904 SH   SOLE   103,904 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 383 115,000 SH   SOLE   115,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 6,894 245,500 SH Put SOLE   245,500 0 0
ARDELYX INC COM 039697107 6,821 1,030,436 SH   SOLE   1,030,436 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 10,408 150,000 SH Call SOLE   150,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 153 2,200 SH   SOLE   2,200 0 0
ARGENX SE SPONSORED ADR 04016X101 7,407 26,900 SH Call SOLE   26,900 0 0
ARGENX SE SPONSORED ADR 04016X101 9,500 34,500 SH Put SOLE   34,500 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 178 2,000 SH   SOLE   2,000 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 75,776 854,000 SH Put SOLE   854,000 0 0
ARK ETF TR INNOVATION ETF 00214Q104 131,945 1,100,000 SH Put SOLE   1,100,000 0 0
ARVINAS INC COM 04335A105 558 8,430 SH   SOLE   8,430 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 8,001 62,090 SH   SOLE   62,090 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 6,534 50,700 SH Call SOLE   50,700 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 243 1,224,516 SH   SOLE   1,224,516 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 334 72,468 SH   SOLE   72,468 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 17,401 350,000 SH Call SOLE   350,000 0 0
ATYR PHARMA INC COM NEW 002120202 1,336 300,000 SH   SOLE   300,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,298 100,000 SH Call SOLE   100,000 0 0
AURIS MEDICAL HOLDING LTD SHS G07025201 1,605 461,522 SH   SOLE   461,522 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 7,196 1,256,048 SH   SOLE   1,256,048 0 0
BAUDAX BIO INC COM 07160F107 129 100,000 SH   SOLE   100,000 0 0
BAUSCH HEALTH COS INC COM 071734107 25,392 800,000 SH Call SOLE   800,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 794 75,100 SH   SOLE   75,100 0 0
BCTG ACQUISITION CORP COM 05492W103 3,340 300,250 SH   SOLE   300,250 0 0
BEAM THERAPEUTICS INC COM 07373V105 28,813 360,000 SH Put SOLE   360,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 55,867 160,500 SH Put SOLE   160,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 3,655 10,500 SH Call SOLE   10,500 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 1,881 500,000 SH   SOLE   500,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 1,537 400,000 SH   SOLE   400,000 0 0
BIOATLA INC COM 09077B104 3,567 70,160 SH   SOLE   70,160 0 0
BIOGEN INC COM 09062X103 1,594 5,700 SH   SOLE   5,700 0 0
BIOGEN INC COM 09062X103 110,475 394,900 SH Call SOLE   394,900 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 6,474 150,000 SH Call SOLE   150,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 226 5,232 SH   SOLE   5,232 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 3,735 153,941 SH   SOLE   153,941 0 0
BLUEBIRD BIO INC COM 09609G100 3,203 106,200 SH Call SOLE   106,200 0 0
BLUEBIRD BIO INC COM 09609G100 8 281 SH   SOLE   281 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 11,667 120,000 SH Put SOLE   120,000 0 0
BOEING CO COM 097023105 15,283 60,000 SH Call SOLE   60,000 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,122 293,200 SH   SOLE   293,200 0 0
C4 THERAPEUTICS INC COM STK 12529R107 4,124 111,500 SH   SOLE   111,500 0 0
CABALETTA BIO INC COM 12674W109 4,323 389,384 SH   SOLE   389,384 0 0
CARA THERAPEUTICS INC COM 140755109 18,379 846,600 SH Call SOLE   846,600 0 0
CARA THERAPEUTICS INC COM 140755109 12,125 558,524 SH   SOLE   558,524 0 0
CARDIFF ONCOLOGY INC COM 14147L108 3,870 417,900 SH Put SOLE   417,900 0 0
CASI PHARMACEUTICALS INC COM 14757U109 3,044 1,268,154 SH   SOLE   1,268,154 0 0
CATABASIS PHARMACEUTICALS IN COM NEW 14875P206 2,464 852,998 SH   SOLE   852,998 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 2,929 581,200 SH   SOLE   581,200 0 0
CEL-SCI CORP COM PAR NEW 150837607 1,627 106,900 SH Call SOLE   106,900 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 10,373 503,500 SH Call SOLE   503,500 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 12,284 596,290 SH   SOLE   596,290 0 0
CERECOR INC COM 15671L109 2,710 897,330 SH   SOLE   897,330 0 0
CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 4,399 400,000 SH   SOLE   400,000 0 0
CHARDAN HEALTHCR ACQSTN 2 CO COM 15957T107 301 30,000 SH   SOLE   30,000 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 769 219,109 SH   SOLE   219,109 0 0
CHEMOCENTRYX INC COM 16383L106 10,248 200,000 SH Call SOLE   200,000 0 0
CHEMOCENTRYX INC COM 16383L106 26,235 512,000 SH Put SOLE   512,000 0 0
CHIASMA INC COM 16706W102 1,909 610,299 SH   SOLE   610,299 0 0
CHIMERIX INC COM 16934W106 1,446 150,000 SH Call SOLE   150,000 0 0
CHIMERIX INC COM 16934W106 15,399 1,597,514 SH   SOLE   1,597,514 0 0
CLENE INC COMMON STOCK 185634102 1,516 118,533 SH   SOLE   118,533 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 757 100,000 SH   SOLE   100,000 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 1,890 250,000 SH Call SOLE   250,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 4,771 679,473 SH   SOLE   679,473 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 8,318 225,926 SH   SOLE   225,926 0 0
COMPUGEN LTD ORD M25722105 4 500 SH Put SOLE   500 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,899 964,100 SH   SOLE   964,100 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 307 100,000 SH   SOLE   100,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 5,105 41,900 SH Put SOLE   41,900 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,838 15,084 SH   SOLE   15,084 0 0
CRYOPORT INC COM PAR $0.001 229050307 151 2,900 SH   SOLE   2,900 0 0
CULLINAN ONCOLOGY INC COM 230031106 42 1,000 SH   SOLE   1,000 0 0
CUREVAC N V COM N2451R105 32,925 360,000 SH Put SOLE   360,000 0 0
CUREVAC N V COM N2451R105 9,145 100,000 SH Call SOLE   100,000 0 0
CURIS INC COM NEW 231269200 1,132 100,000 SH Call SOLE   100,000 0 0
CURIS INC COM NEW 231269200 13,815 1,220,356 SH   SOLE   1,220,356 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 2,133 300,000 SH   SOLE   300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 836 300,000 SH   SOLE   300,000 0 0
CYTOKINETICS INC COM NEW 23282W605 2,954 127,000 SH   SOLE   127,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 3,387 322,730 SH   SOLE   322,730 0 0
DELCATH SYS INC COM NEW 24661P807 546 43,915 SH   SOLE   43,915 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 3,797 415,000 SH   SOLE   415,000 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 2,676 250,000 SH   SOLE   250,000 0 0
ESSA PHARMA INC COM NEW 29668H708 7,694 264,868 SH   SOLE   264,868 0 0
EXACT SCIENCES CORP COM 30063P105 27,015 205,000 SH Put SOLE   205,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 2,116 208,500 SH Call SOLE   208,500 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 1,221 120,135 SH   SOLE   120,135 0 0
FATE THERAPEUTICS INC COM 31189P102 8,978 108,900 SH Put SOLE   108,900 0 0
FATE THERAPEUTICS INC COM 31189P102 297 3,600 SH   SOLE   3,600 0 0
FIBROGEN INC COM 31572Q808 10,412 300,000 SH Put SOLE   300,000 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 2,387 150,000 SH   SOLE   150,000 0 0
FRAZIER LIFESCIENCES ACQU CO UNIT 12/09/2025 G3710A121 766 75,000 SH   SOLE   75,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 958 100,800 SH Put SOLE   100,800 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 1,900 200,000 SH Call SOLE   200,000 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 536 56,479 SH   SOLE   56,479 0 0
FULCRUM THERAPEUTICS INC COM 359616109 5,026 426,739 SH   SOLE   426,739 0 0
GALAPAGOS NV SPON ADR 36315X101 7,709 100,000 SH Call SOLE   100,000 0 0
GALAPAGOS NV SPON ADR 36315X101 15,513 200,000 SH   SOLE   200,000 0 0
GAMIDA CELL LTD SHS M47364100 1,102 136,142 SH   SOLE   136,142 0 0
GEMINI THERAPEUTICS INC COM 36870G105 9,273 684,379 SH   SOLE   684,379 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 213 78,767 SH   SOLE   78,767 0 0
GILEAD SCIENCES INC COM 375558103 28,668 443,600 SH Call SOLE   443,600 0 0
GOSSAMER BIO INC COM 38341P102 2,775 300,000 SH Call SOLE   300,000 0 0
GOSSAMER BIO INC COM 38341P102 9,697 1,048,383 SH   SOLE   1,048,383 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 25,833 119,100 SH Put SOLE   119,100 0 0
HARPOON THERAPEUTICS INC COM 41358P106 5,619 268,600 SH   SOLE   268,600 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 2,246 200,000 SH   SOLE   200,000 0 0
HIGHCAPE CAP ACQUISITION COR COM CL A 42984L105 3,099 260,000 SH   SOLE   260,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 58,186 632,200 SH Call SOLE   632,200 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 56 603 SH   SOLE   603 0 0
I MAB SPONSORED ADS 44975P103 12,117 250,000 SH   SOLE   250,000 0 0
ICAD INC COM NEW 44934S206 4,618 217,637 SH   SOLE   217,637 0 0
IGM BIOSCIENCES INC COM 449585108 19,172 250,000 SH Put SOLE   250,000 0 0
IGM BIOSCIENCES INC COM 449585108 23 300 SH   SOLE   300 0 0
IMMATICS N.V SHS N44445109 2,860 255,138 SH   SOLE   255,138 0 0
IMMUNOPRECISE ANTIBODIES LTD COM NEW 45257F200 1,472 150,000 SH   SOLE   150,000 0 0
IMMUNOVANT INC COM 45258J102 5,802 361,700 SH Call SOLE   361,700 0 0
IMMUNOVANT INC COM 45258J102 3,895 242,800 SH Put SOLE   242,800 0 0
INCYTE CORP COM 45337C102 1,870 23,012 SH   SOLE   23,012 0 0
INCYTE CORP COM 45337C102 16,254 200,000 SH Call SOLE   200,000 0 0
INFLARX NV COM N44821101 2,729 699,750 SH   SOLE   699,750 0 0
INHIBRX INC COM 45720L107 161 8,076 SH   SOLE   8,076 0 0
INMUNE BIO INC COM 45782T105 2,775 233,576 SH   SOLE   233,576 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 808 35,000 SH   SOLE   35,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,308 100,000 SH Call SOLE   100,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,545 75,000 SH Put SOLE   75,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 7,125 210,000 SH Call SOLE   210,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 11,231 330,989 SH   SOLE   330,989 0 0
INVENTIVA SA ADS 46124U107 215 15,000 SH   SOLE   15,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 63,826 200,000 SH Put SOLE   200,000 0 0
INVITAE CORP COM 46185L103 7,642 200,000 SH Put SOLE   200,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 4,047 90,000 SH Call SOLE   90,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 6,332 200,000 SH Put SOLE   200,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432 54,180 400,000 SH Call SOLE   400,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432 40,635 300,000 SH Put SOLE   300,000 0 0
ISHARES TR PHLX SEMICND ETF 464287523 42,398 100,000 SH Put SOLE   100,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 99,422 450,000 SH Put SOLE   450,000 0 0
ISHARES TR NASDAQ BIOTECH 464287556 37,640 250,000 SH Call SOLE   250,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 16,437 100,000 SH Call SOLE   100,000 0 0
KADMON HLDGS INC COM 48283N106 3,644 936,615 SH   SOLE   936,615 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 7,629 296,965 SH   SOLE   296,965 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 9 791 SH   SOLE   791 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 949 51,273 SH   SOLE   51,273 0 0
KINNATE BIOPHARMA INC COM 49705R105 62 2,000 SH   SOLE   2,000 0 0
KURA ONCOLOGY INC COM 50127T109 441 15,603 SH   SOLE   15,603 0 0
KURA ONCOLOGY INC COM 50127T109 3,957 140,000 SH Call SOLE   140,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 6,215 425,384 SH   SOLE   425,384 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 44 1,500 SH Put SOLE   1,500 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 5,196 512,450 SH   SOLE   512,450 0 0
LILLY ELI & CO COM 532457108 23,352 125,000 SH   SOLE   125,000 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 2,560 951,400 SH   SOLE   951,400 0 0
LYRA THERAPEUTICS INC COM 55234L105 9,048 780,728 SH   SOLE   780,728 0 0
MACROGENICS INC COM 556099109 15,940 500,469 SH   SOLE   500,469 0 0
MACROGENICS INC COM 556099109 6,371 200,000 SH Call SOLE   200,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 2,768 23,654 SH   SOLE   23,654 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 419 1,146,308 SH   SOLE   1,146,308 0 0
MERSANA THERAPEUTICS INC COM 59045L106 3,237 200,000 SH Call SOLE   200,000 0 0
MERUS N V COM N5749R100 2,322 111,223 SH   SOLE   111,223 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 10,633 1,836,545 SH   SOLE   1,836,545 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 1,617 1,348,021 SH   SOLE   1,348,021 0 0
MIRATI THERAPEUTICS INC COM 60468T105 16,188 94,500 SH Call SOLE   94,500 0 0
MIRATI THERAPEUTICS INC COM 60468T105 27,751 162,000 SH Put SOLE   162,000 0 0
MODERNA INC COM 60770K107 78,568 600,000 SH Put SOLE   600,000 0 0
MODERNA INC COM 60770K107 13,094 100,000 SH Call SOLE   100,000 0 0
MORPHIC HLDG INC COM 61775R105 3,160 49,925 SH   SOLE   49,925 0 0
MUSTANG BIO INC COM 62818Q104 1,747 526,003 SH   SOLE   526,003 0 0
NEXTCURE INC COM 65343E108 4,544 453,952 SH   SOLE   453,952 0 0
NOVAVAX INC COM NEW 670002401 478 2,636 SH   SOLE   2,636 0 0
NOVAVAX INC COM NEW 670002401 12,693 70,000 SH Call SOLE   70,000 0 0
NOVAVAX INC COM NEW 670002401 35,483 195,700 SH Put SOLE   195,700 0 0
NUVATION BIO INC COM CL A 67080N101 2,613 250,000 SH   SOLE   250,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100 6,885 419,573 SH   SOLE   419,573 0 0
OCULAR THERAPEUTIX INC COM 67576A100 4,301 262,100 SH Call SOLE   262,100 0 0
OCUPHIRE PHARMA INC COM 67577R102 693 119,551 SH   SOLE   119,551 0 0
ODONATE THERAPEUTICS INC COM 676079106 4,571 1,336,412 SH   SOLE   1,336,412 0 0
ONCONOVA THERAPEUTICS INC COM PAR 68232V405 1,144 1,145,426 SH   SOLE   1,145,426 0 0
ONCTERNAL THERAPEUTICS INC COM 68236P107 3,831 460,323 SH   SOLE   460,323 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,815 250,000 SH   SOLE   250,000 0 0
OVID THERAPEUTICS INC COM 690469101 4,522 1,124,872 SH   SOLE   1,124,872 0 0
PANBELA THERAPEUTICS INC COM 69833Q100 1,363 345,013 SH   SOLE   345,013 0 0
PASSAGE BIO INC COM 702712100 2,550 145,858 SH   SOLE   145,858 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 1,745 383,373 SH   SOLE   383,373 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 3,757 100,000 SH   SOLE   100,000 0 0
PLIANT THERAPEUTICS INC COM 729139105 4,275 108,700 SH   SOLE   108,700 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 820 85,837 SH   SOLE   85,837 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 10,223 649,542 SH   SOLE   649,542 0 0
PROTHENA CORP PLC SHS G72800108 10,989 437,430 SH   SOLE   437,430 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 533 54,901 SH   SOLE   54,901 0 0
RAPT THERAPEUTICS INC COM 75382E109 5,550 250,000 SH Call SOLE   250,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 10,459 104,900 SH Put SOLE   104,900 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 60 600 SH   SOLE   600 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 1,943 1,245,989 SH   SOLE   1,245,989 0 0
RELMADA THERAPEUTICS INC COM 75955J402 6,958 197,600 SH Call SOLE   197,600 0 0
RELMADA THERAPEUTICS INC COM 75955J402 10,218 290,207 SH   SOLE   290,207 0 0
REVOLUTION MEDICINES INC COM 76155X100 6,882 150,000 SH Call SOLE   150,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 61 1,400 SH   SOLE   1,400 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 1,326 50,000 SH   SOLE   50,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 18,713 250,000 SH Put SOLE   250,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,805 104,300 SH Call SOLE   104,300 0 0
SAGE THERAPEUTICS INC COM 78667J108 6,823 91,151 SH   SOLE   91,151 0 0
SAREPTA THERAPEUTICS INC COM 803607100 10 134 SH   SOLE   134 0 0
SAREPTA THERAPEUTICS INC COM 803607100 7,453 100,000 SH Call SOLE   100,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 33,978 455,900 SH Put SOLE   455,900 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 3,997 676,294 SH   SOLE   676,294 0 0
SAVARA INC COM 805111101 3,566 1,714,366 SH   SOLE   1,714,366 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 3,397 67,059 SH   SOLE   67,059 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 1,433 28,300 SH Call SOLE   28,300 0 0
SCHRODINGER INC COM 80810D103 7,628 100,000 SH Put SOLE   100,000 0 0
SCPHARMACEUTICALS INC COM 810648105 8,703 1,308,699 SH   SOLE   1,308,699 0 0
SEELOS THERAPEUTICS INC COM 81577F109 3,585 718,284 SH   SOLE   718,284 0 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 49,226 500,000 SH Call SOLE   500,000 0 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 37,773 1,109,400 SH Call SOLE   1,109,400 0 0
SELECT SECTOR SPDR TR SBI INT-UTILS 81369Y886 12,809 200,000 SH Call SOLE   200,000 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 410 48,053 SH   SOLE   48,053 0 0
SERES THERAPEUTICS INC COM 81750R102 7,206 350,000 SH   SOLE   350,000 0 0
SERES THERAPEUTICS INC COM 81750R102 16,061 780,000 SH Call SOLE   780,000 0 0
SHATTUCK LABS INC COM 82024L103 5,566 190,330 SH   SOLE   190,330 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 7,671 445,188 SH   SOLE   445,188 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 155 122,462 SH   SOLE   122,462 0 0
SOLID BIOSCIENCES INC COM 83422E105 131 23,617 SH   SOLE   23,617 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 1,372 165,900 SH   SOLE   165,900 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 217,981 550,000 SH Put SOLE   550,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 128,866 950,000 SH Put SOLE   950,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 47,477 350,000 SH Call SOLE   350,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 1,237 788,014 SH   SOLE   788,014 0 0
STOKE THERAPEUTICS INC COM 86150R107 3,962 102,000 SH Put SOLE   102,000 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 3,203 1,160,450 SH   SOLE   1,160,450 0 0
SUTRO BIOPHARMA INC COM 869367102 4,553 200,000 SH Call SOLE   200,000 0 0
SUTRO BIOPHARMA INC COM 869367102 3,081 135,360 SH   SOLE   135,360 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 914 40,913 SH   SOLE   40,913 0 0
SYNLOGIC INC COM 87166L100 5,343 1,492,614 SH   SOLE   1,492,614 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 748 100,000 SH   SOLE   100,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 3,013 136,486 SH   SOLE   136,486 0 0
TELADOC HEALTH INC COM 87918A105 1,181 6,500 SH Put SOLE   6,500 0 0
TG THERAPEUTICS INC COM 88322Q108 4,820 100,000 SH Put SOLE   100,000 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 22,360 2,716,840 SH   SOLE   2,716,840 0 0
TRANSLATE BIO INC COM 89374L104 4,122 250,000 SH Put SOLE   250,000 0 0
TRICIDA INC COM 89610F101 4,102 775,294 SH   SOLE   775,294 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2,148 200,000 SH Call SOLE   200,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 14,864 120,000 SH Put SOLE   120,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,094 18,400 SH Put SOLE   18,400 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 17,562 105,000 SH Call SOLE   105,000 0 0
UNUM THERAPEUTICS INC COM 19240Q201 367 41,762 SH   SOLE   41,762 0 0
VALLON PHARMACEUTICALS INC COM 92023M101 649 140,000 SH   SOLE   140,000 0 0
VANECK VECTORS ETF TR SEMICONDUCTOR ET 92189F676 24,354 100,000 SH Put SOLE   100,000 0 0
VASCULAR BIOGENICS LTD COM M96883109 1,601 800,811 SH   SOLE   800,811 0 0
VAXCYTE INC COM 92243G108 9,897 501,110 SH   SOLE   501,110 0 0
VERASTEM INC COM 92337C104 6,655 2,694,394 SH   SOLE   2,694,394 0 0
VERICEL CORP COM 92346J108 439 7,900 SH Call SOLE   7,900 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 42,977 200,000 SH Put SOLE   200,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 4,584 724,754 SH   SOLE   724,754 0 0
VINCERX PHARMA INC COM NEW 92731L106 8,467 438,684 SH   SOLE   438,684 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 12,816 250,000 SH Put SOLE   250,000 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 1,439 155,599 SH   SOLE   155,599 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 6,147 2,885,952 SH   SOLE   2,885,952 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,403 250,000 SH Call SOLE   250,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103 10,639 1,235,678 SH   SOLE   1,235,678 0 0
X4 PHARMACEUTICALS INC - PIPE COM 98420X103 11,876 1,379,310 SH   SOLE   1,379,310 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,687 150,100 SH Call SOLE   150,100 0 0
XENON PHARMACEUTICALS INC COM 98420N105 11,467 640,576 SH   SOLE   640,576 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 3,972 219,470 SH   SOLE   219,470 0 0
ZAI LAB LTD ADR 98887Q104 2,249 17,000 SH   SOLE   17,000 0 0
ZOGENIX INC COM NEW 98978L204 16,591 850,000 SH Call SOLE   850,000 0 0
ZOGENIX INC COM NEW 98978L204 2,422 124,091 SH   SOLE   124,091 0 0