The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aerovate Therapeutics, Inc. COMM 008064107 85,811 3,758,686 SH   SOLE   3,758,686 0 0
Akouos, Inc COMM 00973J101 19,014 1,515,074 SH   SOLE   1,515,074 0 0
Amarin Corp ADR 023111206 5,127 1,170,584 SH   SOLE   1,170,584 0 0
Ascendis Pharma A/S ADR 04351P101 68,659 521,923 SH   SOLE   521,923 0 0
Bolt Biotherapeutics, Inc. COMM 097702104 42,584 2,754,437 SH   SOLE   2,754,437 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 21,496 3,606,707 SH   SOLE   3,606,707 0 0
Coherus BioSciences COMM 19249H103 6,010 434,555 SH   SOLE   434,555 0 0
Galera Therapeutics, Inc COMM 36338D108 30,313 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 34,562 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 222,559 1,952,441 SH   SOLE   1,952,441 0 0
Natera COMM 632307104 352,007 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 21,455 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed Ltd ADR 67022C106 15,512 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Biomed Ltd Ordinary Shares GB00BYWYV 6,648 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 14,391 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 1,790 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 2,237 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics, Inc. CL A 92337R101 38,650 2,914,776 SH   SOLE   2,914,776 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 74,167 2,194,278 SH   SOLE   2,194,278 0 0
ACADIA Pharmaceuticals Inc COMM 004225908 2,439 100,000 SH Call SOLE   100,000 0 0
ARK ETF TR Genomic Rev ETF 00214Q952 23,125 250,000 SH Put SOLE   250,000 0 0
Acceleron Pharma Inc COMM 00434H108 29,319 233,638 SH   SOLE   233,638 0 0
Agenus Inc COMM 00847G705 15,207 2,769,900 SH   SOLE   2,769,900 0 0
Agios Pharmaceuticals, Inc. COMM 00847X104 12,071 219,033 SH   SOLE   219,033 0 0
Align Technology Inc COMM 016255101 28,774 47,093 SH   SOLE   47,093 0 0
Aligos Therapeutics Inc COMM 01626L105 3,344 164,051 SH   SOLE   164,051 0 0
Amgen Inc COMM 031162100 9,872 40,500 SH   SOLE   40,500 0 0
AstraZeneca PLC ADR 046353108 57,482 959,632 SH   SOLE   959,632 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 2,508 158,609 SH   SOLE   158,609 0 0
Biogen Inc COMM 09062X103 38,297 110,600 SH   SOLE   110,600 0 0
CTI BioPharma Corp COMM 12648L601 429 171,619 SH   SOLE   171,619 0 0
Celldex Therapeutics, Inc. COMM 15117B202 4,505 134,724 SH   SOLE   134,724 0 0
ChemoCentryx Inc COMM 16383L906 2,879 215,000 SH Call SOLE   215,000 0 0
ChemoCentryx Inc COMM 16383L106 6,235 465,637 SH   SOLE   465,637 0 0
Cyteir Therapeutics, Inc. COMM 23284P103 5,671 265,000 SH   SOLE   265,000 0 0
Cytokinetics Inc COMM 23282W605 9,525 481,323 SH   SOLE   481,323 0 0
Dexcom Inc COMM 252131107 14,395 33,713 SH   SOLE   33,713 0 0
Exelixis Inc COMM 30161Q104 19,672 1,079,681 SH   SOLE   1,079,681 0 0
Fate Therapeutics Inc COMM 31189P102 4,026 46,386 SH   SOLE   46,386 0 0
FibroGen, Inc. COMM 31572Q958 5,326 200,000 SH Put SOLE   200,000 0 0
Heron Therapeutics Inc COMM 427746102 22,778 1,467,675 SH   SOLE   1,467,675 0 0
Immatics NV COMM N44445109 5,148 443,370 SH   SOLE   443,370 0 0
Insmed Inc COMM 457669307 24,025 844,169 SH   SOLE   844,169 0 0
Insulet Corp COMM 45784P101 18,804 68,500 SH   SOLE   68,500 0 0
Intra-Cellular Therapies Inc COMM 46116X101 12,783 313,159 SH   SOLE   313,159 0 0
iShares TR iShares Biotech 464287956 53,186 325,000 SH Put SOLE   325,000 0 0
Jounce Therapeutics Inc COMM 481116101 4,248 624,756 SH   SOLE   624,756 0 0
Kura Oncology Inc COMM 50127T109 9,265 444,372 SH   SOLE   444,372 0 0
MacroGenics Inc COMM 556099109 6,299 234,504 SH   SOLE   234,504 0 0
Marinus Pharmaceuticals Inc COMM 56854Q200 6,210 346,160 SH   SOLE   346,160 0 0
Mirati Therapeutics Inc COMM 60468T105 12,686 78,538 SH   SOLE   78,538 0 0
Mirum Pharmaceuticals Inc COMM 604749101 4,486 259,465 SH   SOLE   259,465 0 0
Neurocrine Biosciences, Inc. COMM 64125C109 19,775 203,200 SH   SOLE   203,200 0 0
Otonomy Inc COMM 68906L105 2,790 1,251,256 SH   SOLE   1,251,256 0 0
PTC Therapeutics Inc COMM 69366J200 24,599 581,940 SH   SOLE   581,940 0 0
Protagonist Therapeutics Inc COMM 74366E102 20,155 449,082 SH   SOLE   449,082 0 0
Reata Pharmaceuticals Inc COMM 75615P103 11,266 79,601 SH   SOLE   79,601 0 0
Regenxbio Inc COMM 75901B107 16,618 427,740 SH   SOLE   427,740 0 0
Replimune Group Inc COMM 76029N106 2,753 71,661 SH   SOLE   71,661 0 0
Sarepta Therapeutics, Inc. COMM 803607100 23,205 298,500 SH   SOLE   298,500 0 0
Savara Inc COMM 805111101 2,173 1,278,424 SH   SOLE   1,278,424 0 0
Sierra Oncology, Inc. COMM 82640U404 49 2,500 SH   SOLE   2,500 0 0
TCR2 Therapeutics Inc COMM 87808K956 2,292 139,700 SH Put SOLE   139,700 0 0
TCR2 Therapeutics Inc COMM 87808K106 4,862 296,282 SH   SOLE   296,282 0 0
Uniqure NV COMM N90064101 9,989 324,303 SH   SOLE   324,303 0 0
United Therapeutics Corp COMM 91307C102 38,768 216,085 SH   SOLE   216,085 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 17,787 88,214 SH   SOLE   88,214 0 0