The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 88,317 17,082,611 SH   DFND   17,082,611 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107 1,622 180,000 SH   DFND   180,000 0 0
AFFIMED NV COM N01045108 27,356 4,426,488 SH   DFND   4,426,488 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 737 452,167 SH   DFND   452,167 0 0
AKOUOS INC COM 00973J101 49,905 4,298,488 SH   DFND   4,298,488 0 0
ALLAKOS INC COM 01671P100 229,177 2,164,704 SH   DFND   2,164,704 0 0
ANNEXON INC COM 03589W102 43,894 2,358,606 SH   DFND   2,358,606 0 0
ARDELYX INC COM 039697107 17,996 13,633,582 SH   DFND   13,633,582 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 114,471 5,172,683 SH   DFND   5,172,683 0 0
AVEO PHARMACEUTICALS INC COM 053588307 24,429 3,952,958 SH   DFND   3,952,958 0 0
BERKSHIRE GREY INC COM CL A 084656107 268,733 38,226,621 SH   DFND   38,226,621 0 0
BILL COM HLDGS INC COM 090043100 149,699 560,774 SH   DFND   560,774 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105 29,186 3,449,845 SH   DFND   3,449,845 0 0
BLOOM ENERGY CORP COM CL A 093712107 24,960 1,333,333 SH   DFND   1,333,333 0 0
BRIGHT HEALTH GROUP INC COM 10920V107 1,780,611 218,212,128 SH   DFND   218,212,128 0 0
CASPER SLEEP INC COM 147626105 26,586 6,226,130 SH   DFND   6,226,130 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 17,497 1,713,720 SH   DFND   1,713,720 0 0
CLOUDFLARE INC CL A COM 18915M107 100,231 889,759 SH   DFND   889,759 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 177,969 1,590,002 SH   DFND   1,590,002 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 21,064 7,140,450 SH   DFND   7,140,450 0 0
COURSERA INC COM 22266M104 502,215 15,867,769 SH   DFND   15,867,769 0 0
CVRX INC COM 126638105 392,140 2,370,858 SH   DFND   2,370,858 0 0
DESKTOP METAL INC COM CL A 25058X105 10,330 14,407,594 SH   DFND   14,407,594 0 0
EARGO INC COM 270087109 30,424 4,520,670 SH   DFND   4,520,670 0 0
ERYTECH PHARMA SA ADR 29604W108 3,606 625,000 SH   DFND   625,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 35,340 4,362,986 SH   DFND   4,362,986 0 0
GENOCEA BIOSCIENCES INC COM 372427401 19,924 10,376,936 SH   DFND   10,376,936 0 0
GERON CORP COM 374163103 18,442 13,461,538 SH   DFND   13,461,538 0 0
GLYCOMIMETICS INC COM 38000Q102 19,904 9,089,041 SH   DFND   9,089,041 0 0
IMARA INC COM 45249V107 16,390 4,017,170 SH   DFND   4,017,170 0 0
INOZYME PHARMA INC COM 45790W108 28,330 2,444,379 SH   DFND   2,444,379 0 0
INVENTIVA SA ADS 46124U107 18,390 1,298,700 SH   DFND   1,298,700 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 11,459 2,382,286 SH   DFND   2,382,286 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 6,862 2,486,062 SH   DFND   2,486,062 0 0
LUMOS PHARMA INC COM 55028X109 5,009 526,663 SH   DFND   526,663 0 0
MARKER THERAPEUTICS INC COM 57055L107 18,107 10,714,285 SH   DFND   10,714,285 0 0
MEI PHARMA INC COM NEW 55279B202 23,551 8,533,072 SH   DFND   8,533,072 0 0
METACRINE INC COM 59101E103 10,506 3,062,977 SH   DFND   3,062,977 0 0
METROMILE INC COM 591697107 33,314 9,384,285 SH   DFND   9,384,285 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 83,421 4,187,801 SH   DFND   4,187,801 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 171,627 7,703,205 SH   DFND   7,703,205 0 0
NKARTA INC COM 65487U108 80,787 2,904,974 SH   DFND   2,904,974 0 0
OBSEVA SA COM H5861P103 14,264 4,586,563 SH   DFND   4,586,563 0 0
OYSTER PT PHARMA INC COM 69242L106 70,215 5,925,287 SH   DFND   5,925,287 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 20,662 6,643,704 SH   DFND   6,643,704 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 4,455 6,451,056 SH   DFND   6,451,056 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 35,663 4,786,921 SH   DFND   4,786,921 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 64,155 4,912,306 SH   DFND   4,912,306 0 0
ROBINHOOD MKTS INC COM CL A 770700102 3,148,358 74,818,398 SH   DFND   74,818,398 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 14,646 3,142,958 SH   DFND   3,142,958 0 0
SAVARA INC COM 805111101 33,310 24,137,931 SH   DFND   24,137,931 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 8,448 4,141,308 SH   DFND   4,141,308 0 0
SYNLOGIC INC COM 87166L100 12,900 4,229,410 SH   DFND   4,229,410 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 1,704 117,785 SH   DFND   117,785 0 0
TRACON PHARMACEUTICALS INC COM 89237H209 1,342 346,718 SH   DFND   346,718 0 0
TREVENA INC COM 89532E109 4,688 3,811,691 SH   DFND   3,811,691 0 0
TREVI THERAPEUTICS INC COM 89532M101 8,317 5,940,796 SH   DFND   5,940,796 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 100,731 5,736,363 SH   DFND   5,736,363 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 51,811 67,069 SH   DFND   67,069 0 0
VERONA PHARMA PLC ADS 925050106 27,950 5,108,563 SH   DFND   5,108,563 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 297 37,093 SH   DFND   37,093 0 0
VISTAGEN THERAPEUTICS INC COM 92840H202 44,669 16,302,596 SH   DFND   16,302,596 0 0
XENON PHARMACEUTICALS INC COM 98420N105 15,159 992,107 SH   DFND   992,107 0 0