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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbCellera Biologics Inc. COM 00288U106 209,422 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 696,137 41,910,704 SH   SOLE   41,910,704 0 0
Acceleron Pharma Inc. COM 00434H108 3,860 22,430 SH   SOLE   22,430 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 20,187 2,591,366 SH   SOLE   2,591,366 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 50,826 9,830,877 SH   SOLE   9,830,877 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 27,110 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107 34,663 1,652,171 SH   SOLE   1,652,171 0 0
Affimed N.V. COM N01045108 1,017 164,605 SH   SOLE   164,605 0 0
Akero Therapeutics, Inc. COM 00973Y108 2,646 118,378 SH   SOLE   118,378 0 0
Albireo Pharma, Inc. COM 01345P106 12,869 412,466 SH   SOLE   412,466 0 0
Alector, Inc. COM 014442107 5,459 239,228 SH   SOLE   239,228 0 0
Aligos Therapeutics, Inc. COM 01626L105 32,205 2,076,400 SH   SOLE   2,076,400 0 0
Alkermes plc SHS G01767105 37,877 1,228,170 SH   SOLE   1,228,170 0 0
Allakos Inc. COM 01671P100 74,432 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 12,125 1,072,038 SH   SOLE   1,072,038 0 0
Amarin Corporation plc SPONSORED ADR 023111206 111,466 21,856,032 SH   SOLE   21,856,032 0 0
Amryt Pharma plc SPONSORED ADR 03217L106 6,244 518,380 SH   SOLE   518,380 0 0
AnaptysBio, Inc. COM 032724106 11,585 427,179 SH   SOLE   427,179 0 0
argenx SE SPONSORED ADR 04016X101 338,106 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 723,886 4,541,604 SH   SOLE   4,541,604 0 0
Athira Pharma, Inc. COM 04746L104 7,564 806,367 SH   SOLE   806,367 0 0
Atreca, Inc. CL A COM 04965G109 22,009 3,532,760 SH   SOLE   3,532,760 0 0
aTyr Pharma, Inc. COM 002120202 5,675 625,000 SH   SOLE   625,000 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 11,519 520,523 SH   SOLE   520,523 0 0
Axsome Therapeutics, Inc. COM 05464T104 17,767 539,057 SH   SOLE   539,057 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 4,235,810 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 727 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 24,288 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 182,654 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 588,988 7,620,494 SH   SOLE   7,620,494 0 0
Biomea Fusion, Inc. COM 09077A106 6,280 524,617 SH   SOLE   524,617 0 0
bluebird bio, Inc. COM 09609G100 47,770 2,499,715 SH   SOLE   2,499,715 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 3,739 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 8,051 662,063 SH   SOLE   662,063 0 0
Centessa Pharmaceuticals plc SPONSORED ADS 152309100 18,825 1,127,273 SH   SOLE   1,127,273 0 0
Cerus Corporation COM 157085101 83,513 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 5,150 301,195 SH   SOLE   301,195 0 0
Chinook Therapeutics, Inc. COM 16961L106 24,283 1,903,069 SH   SOLE   1,903,069 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 19,380 920,656 SH   SOLE   920,656 0 0
Cymabay Therapeutics, Inc. COM 23257D103 7,922 2,170,464 SH   SOLE   2,170,464 0 0
Cyteir Therapeutics, Inc. COM 23284P103 14,262 812,640 SH   SOLE   812,640 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 71,610 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 4,477 88,738 SH   SOLE   88,738 0 0
Design Therapeutics, Inc. COM 25056L103 21,104 1,436,636 SH   SOLE   1,436,636 0 0
DICE Therapeutics, Inc. COM 23345J104 19,265 588,235 SH   SOLE   588,235 0 0
Edgewise Therapeutics, Inc. COM 28036F105 8,300 500,000 SH   SOLE   500,000 0 0
Evofem Biosciences, Inc. COM 30048L104 1,992 2,697,110 SH   SOLE   2,697,110 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 46,957 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 36,071 401,016 SH   SOLE   401,016 0 0
Gamida Cell Ltd. SHS M47364100 2,394 610,626 SH   SOLE   610,626 0 0
Genetron Holdings Limited ADS 37186H100 6,306 455,306 SH   SOLE   455,306 0 0
Global Blood Therapeutics, Inc. COM 37890U108 81,980 3,217,441 SH   SOLE   3,217,441 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 4,738 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 86,928 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100 4,126 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 65,627 599,110 SH   SOLE   599,110 0 0
IGM Biosciences, Inc. COM 449585108 207,545 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 57,509 4,423,731 SH   SOLE   4,423,731 0 0
Immunocore Holdings plc ADS 45258D105 93,443 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,202,482 32,022,125 SH   SOLE   32,022,125 0 0
Inozyme Pharma, Inc. COM 45790W108 1,240 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 59,376 2,156,001 SH   SOLE   2,156,001 0 0
Instil Bio, Inc. COM 45783C101 69,600 3,893,700 SH   SOLE   3,893,700 0 0
Invitae Corporation COM 46185L103 280,703 9,873,488 SH   SOLE   9,873,488 0 0
Iteos Therapeutics, Inc. COM 46565G104 4,059 150,346 SH   SOLE   150,346 0 0
Karuna Therapeutics, Inc. COM 48576A100 8,559 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 1,207 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 31,887 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 1,409,112 14,681,304 SH   SOLE   14,681,304 0 0
Krystal Biotech, Inc. COM 501147102 31,730 607,735 SH   SOLE   607,735 0 0
Kura Oncology, Inc. COM 50127T109 5,697 304,158 SH   SOLE   304,158 0 0
Kymera Therapeutics, Inc. COM 501575104 140,080 2,384,742 SH   SOLE   2,384,742 0 0
Leap Therapeutics, Inc. COM 52187K101 2,244 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 119,524 2,364,003 SH   SOLE   2,364,003 0 0
LogicBio Therapeutics, Inc. COM 54142F102 2,068 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 9,268 442,579 SH   SOLE   442,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 119,622 1,499,213 SH   SOLE   1,499,213 0 0
Mereo BioPharma Group plc ADS 589492107 708 292,692 SH   SOLE   292,692 0 0
Merus N.V. COM N5749R100 44,824 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 249,405 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 12,894 647,313 SH   SOLE   647,313 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 27,631 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 64,929 676,975 SH   SOLE   676,975 0 0
NexImmune, Inc. COM 65344D109 4,453 294,117 SH   SOLE   294,117 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 6,134 291,801 SH   SOLE   291,801 0 0
Novavax, Inc. COM 670002401 22,546 108,756 SH   SOLE   108,756 0 0
Nurix Therapeutics, Inc. COM 67080M103 73,524 2,454,082 SH   SOLE   2,454,082 0 0
Opthea Limited SPONSORED ADS 68386J208 27,062 3,382,797 SH   SOLE   3,382,797 0 0
Otonomy, Inc. COM 68906L105 14,773 7,694,038 SH   SOLE   7,694,038 0 0
Oyster Point Pharma, Inc. COM 69242L106 728 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 139,119 5,444,963 SH   SOLE   5,444,963 0 0
Passage Bio, Inc. COM 702712100 1,167 117,161 SH   SOLE   117,161 0 0
Prelude Therapeutics Inc. COM 74065P101 316,370 10,123,824 SH   SOLE   10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 1,382 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 22,534 223,976 SH   SOLE   223,976 0 0
Relmada Therapeutics, Inc. COM 75955J402 5,268 200,996 SH   SOLE   200,996 0 0
Replimune Group, Inc. COM 76029N106 4,550 153,512 SH   SOLE   153,512 0 0
Revolution Medicines, Inc. COM 76155X100 6,113 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 50,454 3,863,239 SH   SOLE   3,863,239 0 0
Seagen Inc. COM 81181C104 8,029,546 47,288,259 SH   SOLE   47,288,259 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 2,239 201,562 SH   SOLE   201,562 0 0
Surrozen, Inc. COM 86889P109 17,700 2,500,000 SH   SOLE   2,500,000 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117 950 833,333 SH   SOLE   833,333 0 0
Syndax Pharmaceuticals, Inc. COM 87164F105 2,116 110,729 SH   SOLE   110,729 0 0
Talis Biomedical Corporation COM 87424L108 47,343 7,574,835 SH   SOLE   7,574,835 0 0
Tango Therapeutics, Inc. COM 87583X109 9,698 750,000 SH   SOLE   750,000 0 0
TCR2 Therapeutics Inc. COM 87808K106 1,502 176,461 SH   SOLE   176,461 0 0
Travere Therapeutics, Inc. COM 89422G107 49,464 2,039,772 SH   SOLE   2,039,772 0 0
Tricida, Inc. COM 89610F101 4,814 1,037,432 SH   SOLE   1,037,432 0 0
Tscan Therapeutics, Inc. COM 89854M101 11,885 1,425,000 SH   SOLE   1,425,000 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 40,084 444,444 SH   SOLE   444,444 0 0
Verastem, Inc. COM 92337C104 66,194 21,491,630 SH   SOLE   21,491,630 0 0
Verve Therapeutics, Inc. COM 92539P101 66,577 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106 3,903 241,379 SH   SOLE   241,379 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 11,485 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 49,614 1,708,472 SH   SOLE   1,708,472 0 0
Apellis Pharmaceuticals, Inc. Note 3.5% 9/15/2026 03753UAB2 57,262 46,754,000 PRN   SOLE   46,754,000 0 0
BioMarin Pharmaceutical Inc. Note 0.599% 8/1/2024 09061GAH4 4,611 4,500,000 PRN   SOLE   4,500,000 0 0
Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 43,839 40,000,000 PRN   SOLE   40,000,000 0 0
Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 12,570 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 43,167 29,174,000 PRN   SOLE   29,174,000 0 0
Tricida, Inc. Note 3.5% 5/15/2027 89610FAB7 31,375 75,000,000 PRN   SOLE   75,000,000 0 0