The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 10,780 532,350 SH   SOLE   532,350 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100 10,121 375,256 SH   SOLE   375,256 0 0
ABSCI CORPORATION COM 00091E109 17,175 1,476,776 SH   SOLE   1,476,776 0 0
ACCOLADE INC COM 00437E102 11,798 279,774 SH   SOLE   279,774 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 5,884 755,375 SH   SOLE   755,375 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 14,062 781,236 SH   SOLE   781,236 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 11,992 352,804 SH   SOLE   352,804 0 0
ADMA BIOLOGICS INC COM 000899104 14,986 13,262,375 SH   SOLE   13,262,375 0 0
AGILE THERAPEUTICS INC COM 00847L100 15,301 15,919,925 SH   SOLE   15,919,925 0 0
ALBIREO PHARMA INC COM 01345P106 73,636 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 86,956 9,903,879 SH   SOLE   9,903,879 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 5,252 430,900 SH   SOLE   430,900 0 0
AMICUS THERAPEUTICS INC COM 03152W109 253,643 26,559,443 SH   SOLE   26,559,443 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 20,270 615,000 SH   SOLE   615,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 17,323 1,959,652 SH   SOLE   1,959,652 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 79,208 2,259,224 SH   SOLE   2,259,224 0 0
ATHENEX INC COM 04685N103 40,733 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 32,135 3,425,916 SH   SOLE   3,425,916 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 21,818 885,818 SH   SOLE   885,818 0 0
AXSOME THERAPEUTICS INC COM 05464T104 2,651 80,420 SH   SOLE   80,420 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 9,960 1,000,000 SH   SOLE   1,000,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 46,780 537,635 SH   SOLE   537,635 0 0
BIOATLA INC COM 09077B104 25,025 850,026 SH   SOLE   850,026 0 0
BIOGEN INC COM 09062X103 13,753 48,600 SH   SOLE   48,600 0 0
BRIDGEBIO PHARMA INC COM 10806X102 363,567 7,756,928 SH   SOLE   7,756,928 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110 642 233,333 SH   SOLE   233,333 0 0
C4 THERAPEUTICS INC COM STK 12529R107 100,913 2,258,566 SH   SOLE   2,258,566 0 0
CAREMAX INC COM CL A 14171W103 32,699 3,385,000 SH   SOLE   3,385,000 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 170 60,000 SH   SOLE   60,000 0 0
CASSAVA SCIENCES INC COM 14817C107 6,208 100,000 SH Put SOLE   100,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 21,251 393,613 SH   SOLE   393,613 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 150,058 5,086,727 SH   SOLE   5,086,727 0 0
CHEMOCENTRYX INC COM 16383L106 9,405 550,000 SH   SOLE   550,000 0 0
CHEMOCENTRYX INC COM 16383L106 15,786 923,200 SH Call SOLE   923,200 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 11,085 1,500,000 SH   SOLE   1,500,000 0 0
CM LIFE SCIENCES III INC UNIT 04/30/2028 125841205 12,813 1,250,000 SH   SOLE   1,250,000 0 0
CODEX DNA INC COM 192003101 4,730 425,000 SH   SOLE   425,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 26,817 3,188,750 SH   SOLE   3,188,750 0 0
COHERUS BIOSCIENCES INC COM 19249H103 76,805 4,779,387 SH   SOLE   4,779,387 0 0
COHERUS BIOSCIENCES INC NOTE 1.500% 4/1 19249HAB9 49,365 4,500,000 PRN   SOLE   4,500,000 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 180,250 17,500,000 PRN   SOLE   17,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 7,033 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 83,432 3,963,517 SH   SOLE   3,963,517 0 0
CUE HEALTH INC COM 229790100 18,667 1,580,607 SH   SOLE   1,580,607 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 4,915 500,000 SH   SOLE   500,000 0 0
DARIOHEALTH CORP COM NEW 23725P209 4,475 327,869 SH   SOLE   327,869 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 13,195 556,047 SH   SOLE   556,047 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 37,708 7,695,505 SH   SOLE   7,695,505 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 934 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 36,186 505,541 SH   SOLE   505,541 0 0
FERRARI N V COM N3167Y103 1,297 6,200 SH   SOLE   6,200 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 1,569 222,222 SH   SOLE   222,222 0 0
FULCRUM THERAPEUTICS INC COM 359616109 8,297 294,118 SH   SOLE   294,118 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 9,936 1,254,607 SH   SOLE   1,254,607 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 112,300 4,407,399 SH   SOLE   4,407,399 0 0
GRAPHITE BIO INC COM 38870X104 14,343 875,093 SH   SOLE   875,093 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 18,833 491,332 SH   SOLE   491,332 0 0
HEALTH CATALYST INC COM 42225T107 29,456 589,004 SH   SOLE   589,004 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 4,451 450,000 SH   SOLE   450,000 0 0
HEALTHCOR CATALIO ACQU CORP CL A SHS G44125105 14,850 1,500,000 SH   SOLE   1,500,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 214,363 1,956,940 SH   SOLE   1,956,940 0 0
ICOSAVAX INC COM 45114M109 56,888 1,922,549 SH   SOLE   1,922,549 0 0
IMAGO BIOSCIENCES INC COM 45250K107 2,504 125,000 SH   SOLE   125,000 0 0
IMMATICS N.V SHS N44445109 32,500 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107 18,082 681,051 SH   SOLE   681,051 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 14,828 400,000 SH   SOLE   400,000 0 0
INHIBRX INC COM 45720L107 37,357 1,121,490 SH   SOLE   1,121,490 0 0
INSULET CORP COM 45784P101 12,654 44,522 SH   SOLE   44,522 0 0
INVITAE CORP COM 46185L103 111,551 3,923,741 SH   SOLE   3,923,741 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 283,337 11,489,772 SH   SOLE   11,489,772 0 0
IVERIC BIO INC COM 46583P102 121,342 7,471,798 SH   SOLE   7,471,798 0 0
KODIAK SCIENCES INC COM 50015M109 44,271 461,248 SH   SOLE   461,248 0 0
KRONOS BIO INC COM 50107A104 50,747 2,421,142 SH   SOLE   2,421,142 0 0
KYMERA THERAPEUTICS INC COM 501575104 10,573 180,000 SH   SOLE   180,000 0 0
LANDOS BIOPHARMA INC COM 515069102 217,101 14,869,915 SH   SOLE   14,869,915 0 0
LEAP THERAPEUTICS INC COM 52187K101 33,990 8,476,496 SH   SOLE   8,476,496 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 2,940 300,000 SH   SOLE   300,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 29,403 3,222,560 SH   SOLE   3,222,560 0 0
MACROGENICS INC COM 556099109 44,980 2,148,060 SH   SOLE   2,148,060 0 0
MEIRAGTX HLDGS PLC COM G59665102 91,578 6,948,277 SH   SOLE   6,948,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105 599,326 3,387,745 SH   SOLE   3,387,745 0 0
MORPHIC HLDG INC COM 61775R105 50,259 887,340 SH   SOLE   887,340 0 0
MOTUS GI HLDGS INC COM 62014P108 1,242 1,800,542 SH   SOLE   1,800,542 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 12,039 1,059,800 SH   SOLE   1,059,800 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 12,799 1,000,000 PRN   SOLE   1,000,000 0 0
NATERA INC COM 632307104 17,830 160,000 SH   SOLE   160,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 54,714 8,911,151 SH   SOLE   8,911,151 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 6,080 10,055,521 SH   SOLE   10,055,521 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 46,325 483,007 SH   SOLE   483,007 0 0
NEVRO CORP COM 64157F103 30,256 259,972 SH   SOLE   259,972 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 126,234 9,000,000 PRN   SOLE   9,000,000 0 0
NUVALENT INC COM 670703107 16,913 750,000 SH   SOLE   750,000 0 0
NUVATION BIO INC COM CL A 67080N101 30,228 3,041,004 SH   SOLE   3,041,004 0 0
ONCORUS INC COM 68236R103 10,272 1,099,810 SH   SOLE   1,099,810 0 0
OUTSET MED INC COM 690145107 98,417 1,990,633 SH   SOLE   1,990,633 0 0
PHARVARIS N V COM N69605108 479 27,000 SH   SOLE   27,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 8,991 301,714 SH   SOLE   301,714 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 9,557 1,242,879 SH   SOLE   1,242,879 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 5,743 787,745 SH   SOLE   787,745 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 63,214 1,656,990 SH   SOLE   1,656,990 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 78,576 3,314,032 SH   SOLE   3,314,032 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 2,918 421,641 SH   SOLE   421,641 0 0
PROTHENA CORP PLC SHS G72800108 7,123 100,000 SH   SOLE   100,000 0 0
PROVENTION BIO INC COM 74374N102 6,070 948,481 SH   SOLE   948,481 0 0
QUOTIENT LTD SHS G73268107 37,910 16,200,818 SH   SOLE   16,200,818 0 0
RAIN THERAPEUTICS INC COM 75082Q105 37,954 2,537,019 SH   SOLE   2,537,019 0 0
RAPID MICRO BIOSYSTEMS INC CLASS A COM 75340L104 6,465 350,000 SH   SOLE   350,000 0 0
RAPT THERAPEUTICS INC COM 75382E109 90,280 2,907,565 SH   SOLE   2,907,565 0 0
REGENXBIO INC COM 75901B107 3,743 89,283 SH   SOLE   89,283 0 0
RELAY THERAPEUTICS INC COM 75943R102 61,266 1,943,097 SH   SOLE   1,943,097 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 9,850 1,000,000 SH   SOLE   1,000,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 69,054 2,310,261 SH   SOLE   2,310,261 0 0
ROCKLEY PHOTONICS HOLDINGS L *W EXP 08/11/202 G7614L117 1,195 500,000 SH   SOLE   500,000 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 18,975 2,500,000 SH   SOLE   2,500,000 0 0
SIGHT SCIENCES INC COM 82657M105 8,853 390,000 SH   SOLE   390,000 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 34,396 3,073,824 SH   SOLE   3,073,824 0 0
SOLID BIOSCIENCES INC COM 83422E105 32,056 13,412,552 SH   SOLE   13,412,552 0 0
SOMALOGIC INC CLASS A COM 83444K105 25,400 2,050,000 SH   SOLE   2,050,000 0 0
SOMALOGIC INC *W EXP 03/01/202 83444K113 380 110,000 SH   SOLE   110,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 307,678 4,849,912 SH   SOLE   4,849,912 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 10,050 1,000,000 SH   SOLE   1,000,000 0 0
SURROZEN INC COM 86889P109 3,540 500,000 SH   SOLE   500,000 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 190 166,666 SH   SOLE   166,666 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 27,937 1,296,416 SH   SOLE   1,296,416 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 5,967 320,440 SH   SOLE   320,440 0 0
TRAVERE THERAPEUTICS INC NOTE 2.500% 9/1 761299AB2 454,824 45,000,000 PRN   SOLE   45,000,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 47,665 1,965,555 SH   SOLE   1,965,555 0 0
TREACE MED CONCEPTS INC COM 89455T109 33,245 1,235,886 SH   SOLE   1,235,886 0 0
TYRA BIOSCIENCES INC COM 90240B106 17,370 987,500 SH   SOLE   987,500 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 26,155 141,700 SH   SOLE   141,700 0 0
VBI VACCINES INC CDA COM NEW 91822J103 171,182 55,042,465 SH   SOLE   55,042,465 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 15,831 2,888,889 SH   SOLE   2,888,889 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 45,130 3,610,412 SH   SOLE   3,610,412 0 0
VERU INC COM 92536C103 37,970 4,451,342 SH   SOLE   4,451,342 0 0
VIATRIS INC COM 92556V106 13,610 1,004,419 SH   SOLE   1,004,419 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 23,408 1,423,000 SH   SOLE   1,423,000 0 0
VYNE THERAPEUTICS INC COM 92941V209 3,239 2,330,471 SH   SOLE   2,330,471 0 0
XENON PHARMACEUTICALS INC COM 98420N105 30,897 2,022,051 SH   SOLE   2,022,051 0 0
ZYMERGEN INC COM 98985X100 11,633 883,332 SH   SOLE   883,332 0 0
ZYMEWORKS INC COM 98985W102 106,863 3,679,845 SH   SOLE   3,679,845 0 0