The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 3,724 27,500 SH   SOLE   27,500 0 0
ANGIODYNAMICS INC COM 03475V101 14,216 515,450 SH   SOLE   515,450 0 0
APOLLO ENDOSURGERY INC COM 03767D108 19,348 2,295,100 SH   SOLE   2,295,100 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 3,718 40,000 SH   SOLE   40,000 0 0
ARVINAS INC COM 04335A105 904 11,000 SH   SOLE   11,000 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 2,975 300,000 SH   SOLE   300,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 27,878 478,596 SH   SOLE   478,596 0 0
AVALO THERAPEUTICS INC COM 05338F108 1,309 770,000 SH   SOLE   770,000 0 0
BAXTER INTL INC COM 071813109 4,378 51,000 SH   SOLE   51,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 227 2,850 SH   SOLE   2,850 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 624 10,250 SH   SOLE   10,250 0 0
BIOATLA INC COM 09077B104 49,378 2,515,424 SH   SOLE   2,515,424 0 0
BIOVENTUS INC COM CL A 09075A108 6,207 428,397 SH   SOLE   428,397 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 1,443 1,950,000 PRN   SOLE   1,950,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 18,068 561,122 SH   SOLE   561,122 0 0
CARA THERAPEUTICS INC COM 140755109 5,203 427,200 SH   SOLE   427,200 0 0
CELCUITY INC COM 15102K100 423 32,073 SH   SOLE   32,073 0 0
CHEMOCENTRYX INC COM 16383L106 2,488 68,320 SH   SOLE   68,320 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 4,872 298,700 SH   SOLE   298,700 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,667 22,000 SH   SOLE   22,000 0 0
CUTERA INC COM 232109108 3,561 86,180 SH   SOLE   86,180 0 0
CVRX INC COM 126638105 11,767 962,165 SH   SOLE   962,165 0 0
CVS HEALTH CORP COM 126650100 14,236 138,000 SH   SOLE   138,000 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 3,434 350,000 SH   SOLE   350,000 0 0
DEXCOM INC COM 252131107 4,166 7,759 SH   SOLE   7,759 0 0
DICE THERAPEUTICS INC COM 23345J104 20,525 810,940 SH   SOLE   810,940 0 0
DYNE THERAPEUTICS INC COM 26818M108 4,028 338,760 SH   SOLE   338,760 0 0
EDAP TMS S A SPONSORED ADR 268311107 18,860 3,148,609 SH   SOLE   3,148,609 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 23,801 318,275 SH   SOLE   318,275 0 0
ESSA PHARMA INC COM NEW 29668H708 50,061 3,525,457 SH   SOLE   3,525,457 0 0
EVOLUS INC COM 30052C107 8,195 1,258,889 SH   SOLE   1,258,889 0 0
FATE THERAPEUTICS INC COM 31189P102 456 7,800 SH   SOLE   7,800 0 0
FIBROGEN INC COM 31572Q808 21,862 1,550,497 SH   SOLE   1,550,497 0 0
GALAPAGOS NV SPON ADR 36315X101 5,447 98,800 SH   SOLE   98,800 0 0
IMMUNIC INC COM 4525EP101 1,675 175,000 SH   SOLE   175,000 0 0
INSPIRE MED SYS INC COM 457730109 6,315 27,450 SH   SOLE   27,450 0 0
IO BIOTECH INC COM 449778109 4,305 672,734 SH   SOLE   672,734 0 0
IRADIMED CORP COM 46266A109 20,796 450,030 SH   SOLE   450,030 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 113,116 508,500 SH Put SOLE   508,500 0 0
IVERIC BIO INC COM 46583P102 17,863 1,068,376 SH   SOLE   1,068,376 0 0
KRYSTAL BIOTECH INC COM 501147102 15,979 228,437 SH   SOLE   228,437 0 0
LANTHEUS HLDGS INC COM 516544103 50,980 1,764,627 SH   SOLE   1,764,627 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 1,127 231,485 SH   SOLE   231,485 0 0
LYRA THERAPEUTICS INC COM 55234L105 44 10,000 SH   SOLE   10,000 0 0
NATERA INC COM 632307104 21,255 227,599 SH   SOLE   227,599 0 0
NEUROPACE INC COM 641288105 23,275 2,309,003 SH   SOLE   2,309,003 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 230 13,000 SH   SOLE   13,000 0 0
NOVOCURE LTD ORD SHS G6674U108 1,672 22,275 SH   SOLE   22,275 0 0
NURIX THERAPEUTICS INC COM 67080M103 21,517 743,238 SH   SOLE   743,238 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 18,472 1,999,087 SH   SOLE   1,999,087 0 0
PACIRA BIOSCIENCES INC COM 695127100 6,113 101,600 SH   SOLE   101,600 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 2,598 687,412 SH   SOLE   687,412 0 0
SIENTRA INC COM 82621J105 6,943 1,891,878 SH   SOLE   1,891,878 0 0
SMITH & NEPHEW PLC SPDN ADR NEW 83175M205 20,537 593,200 SH   SOLE   593,200 0 0
SPDR SER TR S&P BIOTECH 78464A870 144,652 1,292,000 SH Put SOLE   1,292,000 0 0
STERIS PLC SHS USD G8473T100 12,682 52,100 SH   SOLE   52,100 0 0
SURMODICS INC COM 868873100 25,652 532,757 SH   SOLE   532,757 0 0
THERATECHNOLOGIES INC COM 88338H100 23,307 7,692,082 SH   SOLE   7,692,082 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 35,502 164,300 SH   SOLE   164,300 0 0
VANDA PHARMACEUTICALS INC COM 921659108 2,490 158,700 SH   SOLE   158,700 0 0
VAXCYTE INC COM 92243G108 7,012 294,750 SH   SOLE   294,750 0 0
VERASTEM INC COM 92337C104 3,371 1,644,500 SH   SOLE   1,644,500 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 1,779 90,000 SH   SOLE   90,000 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 769 64,585 SH   SOLE   64,585 0 0
XENON PHARMACEUTICALS INC COM 98420N105 11,840 378,997 SH   SOLE   378,997 0 0
XILIO THERAPEUTICS INC COM 98422T100 7,640 477,495 SH   SOLE   477,495 0 0
Y-MABS THERAPEUTICS INC COM 984241109 5,033 310,494 SH   SOLE   310,494 0 0
ZOGENIX INC COM NEW 98978L204 2,846 175,152 SH   SOLE   175,152 0 0