The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 44,009 2,005,862 SH   DFND 1 0 2,005,862 0
5 01 ACQUISITION CORP COM CL A 33836P105 4,925 500,000 SH   DFND 1 0 500,000 0
AADI BIOSCIENCES INC COM 00032Q104 21,720 899,392 SH   DFND 1 0 899,392 0
AC IMMUNE SA SHS H00263105 34,959 7,062,379 SH   DFND 1 0 7,062,379 0
ACLARIS THERAPEUTICS INC COM 00461U105 24,658 1,695,904 SH   DFND 1 0 1,695,904 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 1,958 289,663 SH   DFND 1 0 289,663 0
AILERON THERAPEUTICS INC COM 00887A105 2,964 5,265,555 SH   DFND 1 0 5,265,555 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 22,015 1,589,495 SH   DFND 1 0 1,589,495 0
AMARIN CORP PLC SPONS ADR NEW 023111206 55,470 16,459,965 SH   DFND 1 0 16,459,965 0
ANGION BIOMEDICA CORP COM 03476J107 3,107 1,071,297 SH   DFND 1 0 1,071,297 0
ARCUS BIOSCIENCES INC COM 03969F109 137,520 3,398,067 SH   DFND 1 0 3,398,067 0
ARGENX SE SPONSORED ADR 04016X101 75,712 216,204 SH   DFND 1 0 216,204 0
BIONOMICS LIMITED ADS 09063M205 1,016 80,971 SH   DFND 1 0 80,971 0
CALITHERA BIOSCIENCES INC COM 13089P101 4,957 7,452,331 SH   DFND 1 0 7,452,331 0
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106 18,570 750,000 SH   DFND 1 0 750,000 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 5,118 454,545 SH   DFND 1 0 454,545 0
CHINOOK THERAPEUTICS INC COM 16961L106 29,358 1,800,000 SH   DFND 1 0 1,800,000 0
CIDARA THERAPEUTICS INC COM 171757107 8,714 6,861,127 SH   DFND 1 0 6,861,127 0
CONCERT PHARMACEUTICALS INC COM 206022105 7,097 2,253,000 SH   DFND 1 0 2,253,000 0
COGENT BIOSCIENCES INC COM 19240Q201 13,147 1,532,282 SH   DFND 1 0 1,532,282 0
CONTRAFECT CORP COM NEW 212326300 10,447 3,972,300 SH   DFND 1 0 3,972,300 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,304 1,370,947 SH   DFND 1 0 1,370,947 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 85,340 3,003,879 SH   DFND 1 0 3,003,879 0
CTI BIOPHARMA CORP COM 12648L601 22,146 8,929,690 SH   DFND 1 0 8,929,690 0
CULLINAN ONCOLOGY INC COM 230031106 82,851 5,369,459 SH   DFND 1 0 5,369,459 0
CYTOMX THERAPEUTICS INC COM 23284F105 25,130 5,803,700 SH   DFND 1 0 5,803,700 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 13,636 809,282 SH   DFND 1 0 809,282 0
ELEDON PHARMACEUTICALS INC COM 28617K101 6,077 1,378,020 SH   DFND 1 0 1,378,020 0
ELEVATION ONCOLOGY INC COM 28623U101 9,702 1,611,698 SH   DFND 1 0 1,611,698 0
EQRX INC COM 26886C107 53,603 7,859,670 SH   DFND 1 0 7,859,670 0
ERYTECH PHARMA SPONSORED ADR 29604W108 3,103 1,314,656 SH   DFND 1 0 1,314,656 0
ESSA PHARMA INC COM NEW 29668H708 40,491 2,851,461 SH   DFND 1 0 2,851,461 0
EUCRATES BIOMEDICAL ACQU COR UNIT 10/23/2027 G3141W114 4,990 500,000 SH   DFND 1 0 500,000 0
FORWARD PHARMA A/S SPONSORD ADS NEW 34986J204 2,584 432,892 SH   DFND 1 0 432,892 0
FRAZIER LIFESCIENCES ACQU CO UNIT 12/09/2025 G3710A121 4,950 500,000 SH   DFND 1 0 500,000 0
GALAPAGOS NV SPON ADR 36315X101 63,752 1,156,393 SH   DFND 1 0 1,156,393 0
GALMED PHARMACEUTICALS LTD SHS M47238106 3,275 1,799,694 SH   DFND 1 0 1,799,694 0
GENERATION BIO CO COM 37148K100 1,338 189,050 SH   DFND 1 0 189,050 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 4,654 4,012,404 SH   DFND 1 0 4,012,404 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 216,389 9,275,158 SH   DFND 1 0 9,275,158 0
GLYCOMIMETICS INC COM 38000Q102 13,744 9,544,262 SH   DFND 1 0 9,544,262 0
IKENA ONCOLOGY INC COM 45175G108 22,552 1,798,371 SH   DFND 1 0 1,798,371 0
INFINITY PHARMACEUTICALS INC COM 45665G303 14,296 6,353,645 SH   DFND 1 0 6,353,645 0
INVENTIVA SA ADS 46124U107 7,438 544,500 SH   DFND 1 0 544,500 0
JANUX THERAPEUTICS INC COM 47103J105 20,072 1,017,314 SH   DFND 1 0 1,017,314 0
JIYA ACQUISITION CORP COM CL A 47760M102 2,931 300,000 SH   DFND 1 0 300,000 0
KURA ONCOLOGY INC COM 50127T109 28,899 2,064,212 SH   DFND 1 0 2,064,212 0
KYMERA THERAPEUTICS INC COM 501575104 201,940 3,180,658 SH   DFND 1 0 3,180,658 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 56,578 14,360,000 SH   DFND 1 0 14,360,000 0
MEI PHARMA INC COM NEW 55279B202 9,431 3,532,057 SH   DFND 1 0 3,532,057 0
MERUS N V COM N5749R100 131,495 4,135,071 SH   DFND 1 0 4,135,071 0
MIRUM PHARMACEUTICALS INC COM 604749101 6,953 435,936 SH   DFND 1 0 435,936 0
MOLECULAR PARTNERS AG ADS 60853G106 8,550 443,221 SH   DFND 1 0 443,221 0
MOLECULAR TEMPLATES INC COM 608550109 12,268 3,129,599 SH   DFND 1 0 3,129,599 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 16,913 955,000 SH   DFND 1 0 955,000 0
NUVALENT INC COM 670703107 8,540 448,512 SH   DFND 1 0 448,512 0
OLEMA PHARMACEUTICALS INC COM 68062P106 69,372 7,411,503 SH   DFND 1 0 7,411,503 0
OVID THERAPEUTICS INC COM 690469101 21,286 6,631,051 SH   DFND 1 0 6,631,051 0
PIERIS PHARMACEUTICALS INC COM 720795103 20,141 5,328,239 SH   DFND 1 0 5,328,239 0
POINT BIOPHARMA GLOBAL INC COM 730541109 16,355 2,920,526 SH   DFND 1 0 2,920,526 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 124,890 3,651,759 SH   DFND 1 0 3,651,759 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 19,651 1,791,351 SH   DFND 1 0 1,791,351 0
RAIN THERAPEUTICS INC COM 75082Q105 38,097 2,957,807 SH   DFND 1 0 2,957,807 0
RELAY THERAPEUTICS INC COM 75943R102 96,141 3,130,605 SH   DFND 1 0 3,130,605 0
RELMADA THERAPEUTICS INC COM 75955J402 37,116 1,647,400 SH   DFND 1 0 1,647,400 0
REPARE THERAPEUTICS INC COM 760273102 102,471 4,858,761 SH   DFND 1 0 4,858,761 0
REPLIMUNE GROUP INC COM 76029N106 25,109 926,529 SH   DFND 1 0 926,529 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 4,860 500,000 SH   DFND 1 0 500,000 0
REVOLUTION MEDICINES INC COM 76155X100 45,572 1,810,549 SH   DFND 1 0 1,810,549 0
REZOLUTE INC COM NEW 76200L309 912 190,815 SH   DFND 1 0 190,815 0
SELECTA BIOSCIENCES INC COM 816212104 5,617 1,723,133 SH   DFND 1 0 1,723,133 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 15,600 666,666 SH   DFND 1 0 666,666 0
SPERO THERAPEUTICS INC COM 84833T103 25,386 1,585,615 SH   DFND 1 0 1,585,615 0
SUTRO BIOPHARMA INC COM 869367102 13,766 925,148 SH   DFND 1 0 925,148 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 45,963 2,099,714 SH   DFND 1 0 2,099,714 0
TYRA BIOSCIENCES INC COM 90240B106 26,358 1,873,332 SH   DFND 1 0 1,873,332 0
VERASTEM INC COM 92337C104 34,977 17,062,158 SH   DFND 1 0 17,062,158 0
VIRACTA THERAPEUTICS INC COM 92765F108 12,552 3,438,944 SH   DFND 1 0 3,438,944 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 37,156 1,879,412 SH   DFND 1 0 1,879,412 0
VOYAGER THERAPEUTICS INC COM 92915B106 60 22,200 SH   DFND 1 0 22,200 0
X4 PHARMACEUTICALS INC COM 98420X103 1,942 847,879 SH   DFND 1 0 847,879 0
XENON PHARMACEUTICALS INC COM 98420N105 102,765 3,289,540 SH   DFND 1 0 3,289,540 0
XOMA CORP DEL COM NEW 98419J206 73,612 3,530,543 SH   DFND 1 0 3,530,543 0