The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 9,353 532,350 SH   SOLE   532,350 0 0
ABSCI CORPORATION COM 00091E109 11,577 1,411,776 SH   SOLE   1,411,776 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 36,972 1,584,052 SH   SOLE   1,584,052 0 0
ACCOLADE INC COM 00437E102 6,030 228,774 SH   SOLE   228,774 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 3,784 755,375 SH   SOLE   755,375 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 11,359 781,236 SH   SOLE   781,236 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 9,900 352,804 SH   SOLE   352,804 0 0
ADMA BIOLOGICS INC COM 000899104 16,826 11,933,387 SH   SOLE   11,933,387 0 0
AGILE THERAPEUTICS INC COM 00847L100 10,394 21,294,485 SH   SOLE   21,294,485 0 0
ALBIREO PHARMA INC COM 01345P106 54,968 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 39,616 9,903,879 SH   SOLE   9,903,879 0 0
AMICUS THERAPEUTICS INC COM 03152W109 306,762 26,559,443 SH   SOLE   26,559,443 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 68,636 1,451,700 SH   SOLE   1,451,700 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 46,470 500,000 SH   SOLE   500,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 6,905 1,281,197 SH   SOLE   1,281,197 0 0
ATHENEX INC COM 04685N103 18,404 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 44,640 3,425,916 SH   SOLE   3,425,916 0 0
AXSOME THERAPEUTICS INC COM 05464T104 3,038 80,420 SH   SOLE   80,420 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 9,800 1,000,000 SH   SOLE   1,000,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 61,544 7,645,234 SH   SOLE   7,645,234 0 0
BIOATLA INC COM 09077B104 12,979 661,200 SH   SOLE   661,200 0 0
BIOGEN INC COM 09062X103 11,660 48,600 SH   SOLE   48,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 104,253 1,180,000 SH   SOLE   1,180,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 118,907 7,128,755 SH   SOLE   7,128,755 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110 296 233,333 SH   SOLE   233,333 0 0
C4 THERAPEUTICS INC COM STK 12529R107 71,126 2,208,913 SH   SOLE   2,208,913 0 0
CAREMAX INC COM CL A 14171W103 27,260 3,549,525 SH   SOLE   3,549,525 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 84 60,000 SH   SOLE   60,000 0 0
CASSAVA SCIENCES INC COM 14817C107 13,110 300,000 SH Put SOLE   300,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 8,880 229,807 SH   SOLE   229,807 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 164,911 5,086,727 SH   SOLE   5,086,727 0 0
CHEMOCENTRYX INC COM 16383L106 51,536 1,415,446 SH   SOLE   1,415,446 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 5,580 1,500,000 SH   SOLE   1,500,000 0 0
CODEX DNA INC COM 192003101 4,590 425,000 SH   SOLE   425,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 27,359 3,188,750 SH   SOLE   3,188,750 0 0
COHERUS BIOSCIENCES INC COM 19249H103 86,308 5,407,798 SH   SOLE   5,407,798 0 0
COHERUS BIOSCIENCES INC NOTE 1.500% 4/1 19249HAB9 51,489 4,500,000 PRN   SOLE   4,500,000 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 169,313 17,500,000 PRN   SOLE   17,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,774 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 146,696 5,163,517 SH   SOLE   5,163,517 0 0
CRYOLIFE INC COM 228903100 6,641 326,318 SH   SOLE   326,318 0 0
CUE HEALTH INC COM 229790100 21,196 1,580,607 SH   SOLE   1,580,607 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 4,905 500,000 SH   SOLE   500,000 0 0
DARIOHEALTH CORP COM NEW 23725P209 4,252 327,869 SH   SOLE   327,869 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 9,369 556,047 SH   SOLE   556,047 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1,954 200,000 SH Call SOLE   200,000 0 0
DICE THERAPEUTICS INC COM 23345J104 17,841 704,885 SH   SOLE   704,885 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 726 139,890 SH   SOLE   139,890 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106 5,150 781,615 SH   SOLE   781,615 0 0
EQRX INC COM 26886C107 8,525 1,250,000 SH   SOLE   1,250,000 0 0
EQRX INC *W EXP 12/17/202 26886C115 266 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 27,411 405,541 SH   SOLE   405,541 0 0
FERRARI N V COM N3167Y103 1,605 6,200 SH   SOLE   6,200 0 0
FULCRUM THERAPEUTICS INC COM 359616109 5,203 294,118 SH   SOLE   294,118 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 5,117 1,227,017 SH   SOLE   1,227,017 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 100,979 3,449,915 SH   SOLE   3,449,915 0 0
GRAPHITE BIO INC COM 38870X104 10,567 850,093 SH   SOLE   850,093 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 10,202 239,258 SH   SOLE   239,258 0 0
HEALTH CATALYST INC COM 42225T107 17,988 454,004 SH   SOLE   454,004 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 4,536 450,000 SH   SOLE   450,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 187,301 1,738,140 SH   SOLE   1,738,140 0 0
HYPERFINE INC COM CL A 44916K106 10,875 1,500,000 SH   SOLE   1,500,000 0 0
ICOSAVAX INC COM 45114M109 43,621 1,906,548 SH   SOLE   1,906,548 0 0
IMMATICS N.V SHS N44445109 33,600 2,500,000 SH   SOLE   2,500,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107 11,013 681,051 SH   SOLE   681,051 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 12,326 360,000 SH   SOLE   360,000 0 0
INHIBRX INC COM 45720L107 58,670 1,343,490 SH   SOLE   1,343,490 0 0
INVITAE CORP COM 46185L103 24,197 1,584,585 SH   SOLE   1,584,585 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 193,342 10,127,941 SH   SOLE   10,127,941 0 0
ISOPLEXIS CORP COM 465005106 37,637 4,095,498 SH   SOLE   4,095,498 0 0
ITEOS THERAPEUTICS INC COM 46565G104 931 20,000 SH   SOLE   20,000 0 0
IVERIC BIO INC COM 46583P102 108,346 6,480,000 SH   SOLE   6,480,000 0 0
KODIAK SCIENCES INC COM 50015M109 44,098 520,152 SH   SOLE   520,152 0 0
KRONOS BIO INC COM 50107A104 32,903 2,421,142 SH   SOLE   2,421,142 0 0
KYMERA THERAPEUTICS INC COM 501575104 9,841 155,000 SH   SOLE   155,000 0 0
LANDOS BIOPHARMA INC COM 515069102 71,375 14,869,915 SH   SOLE   14,869,915 0 0
LEAP THERAPEUTICS INC COM 52187K101 27,463 8,476,496 SH   SOLE   8,476,496 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 8,814 189,100 SH   SOLE   189,100 0 0
LIANBIO SPONSORED ADS 53000N108 346,931 56,319,960 SH   SOLE   56,319,960 0 0
LYRA THERAPEUTICS INC COM 55234L105 14,050 3,222,560 SH   SOLE   3,222,560 0 0
MACROGENICS INC COM 556099109 26,727 1,665,243 SH   SOLE   1,665,243 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 7,322 86,400 SH   SOLE   86,400 0 0
MEIRAGTX HLDGS PLC COM G59665102 164,952 6,948,277 SH   SOLE   6,948,277 0 0
MERUS N V COM N5749R100 11,130 350,000 SH   SOLE   350,000 0 0
MINERVA SURGICAL INC COM 60343F106 451 87,768 SH   SOLE   87,768 0 0
MIRATI THERAPEUTICS INC COM 60468T105 481,698 3,283,783 SH   SOLE   3,283,783 0 0
MORPHIC HLDG INC COM 61775R105 39,634 836,521 SH   SOLE   836,521 0 0
MOTUS GI HLDGS INC COM 62014P108 841 1,800,542 SH   SOLE   1,800,542 0 0
NANOBIOTIX SA SPONSORED ADS 63009J107 8,584 1,059,800 SH   SOLE   1,059,800 0 0
NANOSTRING TECHNOLOGIES INC NOTE 2.625% 3/0 63009RAD1 11,983 1,000,000 PRN   SOLE   1,000,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 47,195 9,111,151 SH   SOLE   9,111,151 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 4,123 10,055,521 SH   SOLE   10,055,521 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 41,138 483,007 SH   SOLE   483,007 0 0
NEVRO CORP COM 64157F103 1,860 22,946 SH   SOLE   22,946 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 101,520 9,000,000 PRN   SOLE   9,000,000 0 0
NUVALENT INC COM 670703107 14,280 750,000 SH   SOLE   750,000 0 0
NUVATION BIO INC COM CL A 67080N101 24,826 2,920,823 SH   SOLE   2,920,823 0 0
ONCORUS INC COM 68236R103 5,269 999,812 SH   SOLE   999,812 0 0
OUTSET MED INC COM 690145107 85,884 1,863,397 SH   SOLE   1,863,397 0 0
PEAR THERAPEUTICS INC CLASS A COM 704723105 5,742 926,232 SH   SOLE   926,232 0 0
PHARVARIS N V COM N69605108 389 27,000 SH   SOLE   27,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,888 125,000 SH   SOLE   125,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 6,686 1,193,995 SH   SOLE   1,193,995 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 33,220 1,328,285 SH   SOLE   1,328,285 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 125,452 3,172,785 SH   SOLE   3,172,785 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 2,846 421,641 SH   SOLE   421,641 0 0
PROTHENA CORP PLC SHS G72800108 4,940 100,000 SH   SOLE   100,000 0 0
PROVENTION BIO INC COM 74374N102 5,330 948,481 SH   SOLE   948,481 0 0
PULMONX CORP COM 745848101 24,447 762,304 SH   SOLE   762,304 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 21,326 1,944,114 SH   SOLE   1,944,114 0 0
QUOTIENT LTD SHS G73268107 41,960 16,200,818 SH   SOLE   16,200,818 0 0
RAIN THERAPEUTICS INC COM 75082Q105 31,989 2,483,619 SH   SOLE   2,483,619 0 0
RAPID MICRO BIOSYSTEMS INC CLASS A COM 75340L104 4,104 385,693 SH   SOLE   385,693 0 0
RAPT THERAPEUTICS INC COM 75382E109 107,529 2,927,565 SH   SOLE   2,927,565 0 0
RELAY THERAPEUTICS INC COM 75943R102 59,672 1,943,097 SH   SOLE   1,943,097 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 9,770 1,000,000 SH   SOLE   1,000,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 42,768 1,959,125 SH   SOLE   1,959,125 0 0
ROCKLEY PHOTONICS HOLDINGS L *W EXP 08/11/202 G7614L117 605 500,000 SH   SOLE   500,000 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 18,705 1,500,000 SH   SOLE   1,500,000 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 11,150 2,500,000 SH   SOLE   2,500,000 0 0
SIGHT SCIENCES INC COM 82657M105 6,852 390,000 SH   SOLE   390,000 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 38,539 3,333,824 SH   SOLE   3,333,824 0 0
SOLID BIOSCIENCES INC COM 83422E105 23,472 13,412,552 SH   SOLE   13,412,552 0 0
SOMALOGIC INC CLASS A COM 83444K105 17,460 1,500,000 SH   SOLE   1,500,000 0 0
SOMALOGIC INC *W EXP 08/31/202 83444K113 367 110,000 SH   SOLE   110,000 0 0
SONENDO INC COM 835431107 3,851 668,505 SH   SOLE   668,505 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 300,598 4,849,912 SH   SOLE   4,849,912 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 9,950 1,000,000 SH   SOLE   1,000,000 0 0
SURROZEN INC COM 86889P109 2,663 413,446 SH   SOLE   413,446 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 192 166,666 SH   SOLE   166,666 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 29,169 1,296,416 SH   SOLE   1,296,416 0 0
TRAVERE THERAPEUTICS INC NOTE 2.500% 9/1 761299AB2 484,736 45,000,000 PRN   SOLE   45,000,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 57,286 1,845,555 SH   SOLE   1,845,555 0 0
TREACE MED CONCEPTS INC COM 89455T109 18,271 980,186 SH   SOLE   980,186 0 0
TYRA BIOSCIENCES INC COM 90240B106 9,474 673,352 SH   SOLE   673,352 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 20,325 94,064 SH   SOLE   94,064 0 0
VBI VACCINES INC CDA COM NEW 91822J103 122,463 52,335,002 SH   SOLE   52,335,002 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 19,270 2,867,510 SH   SOLE   2,867,510 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 33,071 3,610,412 SH   SOLE   3,610,412 0 0
VERU INC COM 92536C103 26,218 4,451,342 SH   SOLE   4,451,342 0 0
VIATRIS INC COM 92556V106 13,590 1,004,419 SH   SOLE   1,004,419 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 28,134 1,423,053 SH   SOLE   1,423,053 0 0
VYNE THERAPEUTICS INC COM 92941V209 2,222 2,178,022 SH   SOLE   2,178,022 0 0
XENON PHARMACEUTICALS INC COM 98420N105 75,334 2,411,447 SH   SOLE   2,411,447 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 36,192 430,544 SH   SOLE   430,544 0 0
ZYMERGEN INC COM 98985X100 5,909 883,332 SH   SOLE   883,332 0 0
ZYMEWORKS INC COM 98985W102 60,312 3,679,845 SH   SOLE   3,679,845 0 0