The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 40,288 | 2,664,521 | SH | DFND | 1 | 0 | 2,664,521 | 0 | |
| AADI BIOSCIENCE INC | COM | 00032Q104 | 14,918 | 879,085 | SH | DFND | 1 | 0 | 879,085 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 29,714 | 7,428,379 | SH | DFND | 1 | 0 | 7,428,379 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 68,556 | 3,976,543 | SH | DFND | 1 | 0 | 3,976,543 | 0 | |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | 1,133 | 289,663 | SH | DFND | 1 | 0 | 289,663 | 0 | |
| AILERON THERAPEUTICS INC | COM | 00887A105 | 2,698 | 5,265,555 | SH | DFND | 1 | 0 | 5,265,555 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 14,258 | 1,589,495 | SH | DFND | 1 | 0 | 1,589,495 | 0 | |
| AN2 THERAPEUTICS INC | COM | 037326105 | 24,363 | 1,616,665 | SH | DFND | 1 | 0 | 1,616,665 | 0 | |
| ANGION BIOMEDICA CORP | COM | 03476J107 | 2,271 | 1,071,297 | SH | DFND | 1 | 0 | 1,071,297 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 125,008 | 3,960,948 | SH | DFND | 1 | 0 | 3,960,948 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 99,702 | 316,204 | SH | DFND | 1 | 0 | 316,204 | 0 | |
| BIONOMICS LIMITED | ADS | 09063M205 | 692 | 80,971 | SH | DFND | 1 | 0 | 80,971 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 3,755 | 9,294,923 | SH | DFND | 1 | 0 | 9,294,923 | 0 | |
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 13,898 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 15,747 | 1,755,545 | SH | DFND | 1 | 0 | 1,755,545 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 5,713 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | |
| CINCOR PHARMA INC | COM | 17240Y109 | 30,437 | 1,735,293 | SH | DFND | 1 | 0 | 1,735,293 | 0 | |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 11,477 | 1,532,282 | SH | DFND | 1 | 0 | 1,532,282 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 7,593 | 2,253,000 | SH | DFND | 1 | 0 | 2,253,000 | 0 | |
| CONTRAFECT CORP | COM NEW | 212326300 | 14,499 | 3,972,300 | SH | DFND | 1 | 0 | 3,972,300 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 2,248 | 1,370,947 | SH | DFND | 1 | 0 | 1,370,947 | 0 | |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 65,935 | 3,003,879 | SH | DFND | 1 | 0 | 3,003,879 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 41,702 | 8,929,690 | SH | DFND | 1 | 0 | 8,929,690 | 0 | |
| CULLINAN ONCOLOGY INC | COM | 230031106 | 56,218 | 5,369,459 | SH | DFND | 1 | 0 | 5,369,459 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 15,496 | 5,803,700 | SH | DFND | 1 | 0 | 5,803,700 | 0 | |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 8,028 | 809,282 | SH | DFND | 1 | 0 | 809,282 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 9,167 | 2,326,710 | SH | DFND | 1 | 0 | 2,326,710 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 5,827 | 2,312,198 | SH | DFND | 1 | 0 | 2,312,198 | 0 | |
| EQRX INC | COM | 26886C107 | 49,666 | 12,025,570 | SH | DFND | 1 | 0 | 12,025,570 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 2,393 | 1,314,656 | SH | DFND | 1 | 0 | 1,314,656 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 22,839 | 3,695,629 | SH | DFND | 1 | 0 | 3,695,629 | 0 | |
| FORWARD PHARMA A/S | SPONSORD ADS NEW | 34986J204 | 2,515 | 432,892 | SH | DFND | 1 | 0 | 432,892 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 64,890 | 1,046,283 | SH | DFND | 1 | 0 | 1,046,283 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 2,862 | 1,799,694 | SH | DFND | 1 | 0 | 1,799,694 | 0 | |
| GENERATION BIO CO | COM | 37148K100 | 20,574 | 2,802,950 | SH | DFND | 1 | 0 | 2,802,950 | 0 | |
| GENOCEA BIOSCIENCES INC | COM NEW | 372427401 | 5,016 | 4,012,404 | SH | DFND | 1 | 0 | 4,012,404 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 169,643 | 9,275,158 | SH | DFND | 1 | 0 | 9,275,158 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 10,880 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 17,910 | 1,600,559 | SH | DFND | 1 | 0 | 1,600,559 | 0 | |
| IKENA ONCOLOGY INC | COM | 45175G108 | 15,260 | 2,501,571 | SH | DFND | 1 | 0 | 2,501,571 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 7,243 | 6,353,645 | SH | DFND | 1 | 0 | 6,353,645 | 0 | |
| INVENTIVA SA | ADS | 46124U107 | 7,937 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 45,058 | 1,400,201 | SH | DFND | 1 | 0 | 1,400,201 | 0 | |
| JANUX THERAPEUTICS INC | COM | 47103J105 | 16,381 | 1,142,340 | SH | DFND | 1 | 0 | 1,142,340 | 0 | |
| JOUNCE THERAPEUTICS INC | COM | 481116101 | 861 | 126,797 | SH | DFND | 1 | 0 | 126,797 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 51,517 | 3,203,783 | SH | DFND | 1 | 0 | 3,203,783 | 0 | |
| KYMERA THERAPEUTICS INC | COM | 501575104 | 151,787 | 3,586,658 | SH | DFND | 1 | 0 | 3,586,658 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 30,005 | 14,356,589 | SH | DFND | 1 | 0 | 14,356,589 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 2,128 | 3,532,057 | SH | DFND | 1 | 0 | 3,532,057 | 0 | |
| MERUS N V | COM | N5749R100 | 109,331 | 4,135,071 | SH | DFND | 1 | 0 | 4,135,071 | 0 | |
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 8,984 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 13,961 | 4,046,735 | SH | DFND | 1 | 0 | 4,046,735 | 0 | |
| NGM BIOPHARMACEUTICALS INC | COM | 62921N105 | 14,564 | 955,000 | SH | DFND | 1 | 0 | 955,000 | 0 | |
| NUVALENT INC | COM | 670703107 | 9,576 | 689,418 | SH | DFND | 1 | 0 | 689,418 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 31,573 | 7,411,503 | SH | DFND | 1 | 0 | 7,411,503 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 21,512 | 6,851,051 | SH | DFND | 1 | 0 | 6,851,051 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 16,145 | 5,328,239 | SH | DFND | 1 | 0 | 5,328,239 | 0 | |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 26,842 | 3,367,826 | SH | DFND | 1 | 0 | 3,367,826 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 99,059 | 4,183,219 | SH | DFND | 1 | 0 | 4,183,219 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 11,562 | 2,861,851 | SH | DFND | 1 | 0 | 2,861,851 | 0 | |
| RADIUS HEALTH INC | COM NEW | 750469207 | 3,338 | 378,000 | SH | DFND | 1 | 0 | 378,000 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 17,881 | 3,526,729 | SH | DFND | 1 | 0 | 3,526,729 | 0 | |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 135,601 | 4,530,605 | SH | DFND | 1 | 0 | 4,530,605 | 0 | |
| RELMADA THERAPEUTICS INC | COM | 75955J402 | 44,463 | 1,647,400 | SH | DFND | 1 | 0 | 1,647,400 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 83,429 | 5,858,776 | SH | DFND | 1 | 0 | 5,858,776 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 15,732 | 926,529 | SH | DFND | 1 | 0 | 926,529 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 46,187 | 1,810,549 | SH | DFND | 1 | 0 | 1,810,549 | 0 | |
| REZOLUTE INC | COM NEW | 76200L309 | 645 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 2,119 | 1,723,133 | SH | DFND | 1 | 0 | 1,723,133 | 0 | |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 12,667 | 666,666 | SH | DFND | 1 | 0 | 666,666 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 13,795 | 1,585,615 | SH | DFND | 1 | 0 | 1,585,615 | 0 | |
| SUTRO BIOPHARMA INC | COM | 869367102 | 28,342 | 3,447,946 | SH | DFND | 1 | 0 | 3,447,946 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 41,620 | 2,394,714 | SH | DFND | 1 | 0 | 2,394,714 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 26,454 | 2,472,327 | SH | DFND | 1 | 0 | 2,472,327 | 0 | |
| VERASTEM INC | COM | 92337C104 | 28,164 | 19,974,658 | SH | DFND | 1 | 0 | 19,974,658 | 0 | |
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 17,206 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 32,247 | 1,744,012 | SH | DFND | 1 | 0 | 1,744,012 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 9,061 | 1,189,100 | SH | DFND | 1 | 0 | 1,189,100 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 1,484 | 847,879 | SH | DFND | 1 | 0 | 847,879 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 48,850 | 1,597,966 | SH | DFND | 1 | 0 | 1,597,966 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 98,785 | 3,530,543 | SH | DFND | 1 | 0 | 3,530,543 | 0 | |