The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 1 99 SH   SOLE   99 0 0
AADI BIOSCIENCE INC COM 00032Q104 3,536 208,368 SH   SOLE   208,368 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 46 1,882 SH   SOLE   1,882 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 208 12,124 SH   SOLE   12,124 0 0
ADICET BIO INC COM 007002108 1,241 62,100 SH Call SOLE   62,100 0 0
ADICET BIO INC COM 007002108 10,132 507,348 SH   SOLE   507,348 0 0
AGENUS INC COM NEW 00847G705 267 108,933 SH   SOLE   108,933 0 0
AILERON THERAPEUTICS INC COM 00887A105 1,487 2,902,086 SH   SOLE   2,902,086 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 860 1,200,000 SH Put SOLE   1,200,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 575 800,000 SH Call SOLE   800,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,667 375,000 SH   SOLE   375,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 201 1,237 SH   SOLE   1,237 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 19,235 117,800 SH Put SOLE   117,800 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 22,077 135,200 SH Call SOLE   135,200 0 0
ALTAMIRA THERAPEUTICS LTD SHS G0360L100 351 320,010 SH   SOLE   320,010 0 0
AMGEN INC COM 031162100 4,837 20,000 SH   SOLE   20,000 0 0
AMGEN INC COM 031162100 24,182 100,000 SH Call SOLE   100,000 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 70 37,248 SH   SOLE   37,248 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 5,097 396,654 SH   SOLE   396,654 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 3,213 250,000 SH Call SOLE   250,000 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103 1,225 181,199 SH   SOLE   181,199 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 8,896 175,100 SH Call SOLE   175,100 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 440 412,293 SH   SOLE   412,293 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 147 106,952 SH   SOLE   106,952 0 0
ARCUS BIOSCIENCES INC COM 03969F109 4,734 150,000 SH Call SOLE   150,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 1,028 8,763 SH   SOLE   8,763 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 192 970,747 SH   SOLE   970,747 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 468 227,076 SH   SOLE   227,076 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 619 92,223 SH   SOLE   92,223 0 0
ATHENEX INC COM 04685N103 68 80,039 SH   SOLE   80,039 0 0
ATHIRA PHARMA INC COM 04746L104 2,700 200,000 SH Put SOLE   200,000 0 0
ATHIRA PHARMA INC COM 04746L104 10,587 784,200 SH Call SOLE   784,200 0 0
ATYR PHARMA INC COM NEW 002120202 197 37,017 SH   SOLE   37,017 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,077 87,071 SH   SOLE   87,071 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,552 372,217 SH   SOLE   372,217 0 0
AVALO THERAPEUTICS INC COM 05338F108 554 764,271 SH   SOLE   764,271 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 2,819 708,383 SH   SOLE   708,383 0 0
BAUDAX BIO INC COM NEW 07160F206 4 2,966 SH   SOLE   2,966 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 762 77,274 SH   SOLE   77,274 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 1,131 523,348 SH   SOLE   523,348 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 6,283 913,327 SH   SOLE   913,327 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 11,617 264,700 SH Call SOLE   264,700 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 4,677 106,600 SH Put SOLE   106,600 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 21,009 478,784 SH   SOLE   478,784 0 0
BIOGEN INC COM 09062X103 23,629 112,200 SH Call SOLE   112,200 0 0
BIOGEN INC COM 09062X103 237 1,122 SH   SOLE   1,122 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,114 60,000 SH   SOLE   60,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,856 50,000 SH   SOLE   50,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 24,192 313,800 SH Call SOLE   313,800 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 113 5,428 SH   SOLE   5,428 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 441 159,390 SH   SOLE   159,390 0 0
BLUEBIRD BIO INC COM 09609G100 1 306 SH   SOLE   306 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 4,088 64,000 SH Call SOLE   64,000 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,022 304,161 SH   SOLE   304,161 0 0
BRIGHT MINDS BIOSCIENCES INC COM 10919W108 161 105,958 SH   SOLE   105,958 0 0
CABALETTA BIO INC COM 12674W109 2,070 1,020,070 SH   SOLE   1,020,070 0 0
CABALETTA BIO INC COM 12674W109 912 449,000 SH Call SOLE   449,000 0 0
CASI PHARMACEUTICALS INC COM 14757U109 1,067 1,320,155 SH   SOLE   1,320,155 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 314 476,625 SH   SOLE   476,625 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 18,323 537,958 SH   SOLE   537,958 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 11,718 344,100 SH Call SOLE   344,100 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 20,282 595,500 SH Put SOLE   595,500 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 1,292 268,104 SH   SOLE   268,104 0 0
CHIMERIX INC COM 16934W106 3,852 841,203 SH   SOLE   841,203 0 0
CLENE INC COMMON STOCK 185634102 2,026 514,283 SH   SOLE   514,283 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,561 772,339 SH   SOLE   772,339 0 0
CODIAK BIOSCIENCES INC COM 192010106 328 52,177 SH   SOLE   52,177 0 0
COMPASS THERAPEUTICS INC COM 20454B104 100 74,171 SH   SOLE   74,171 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 2,047 677,859 SH   SOLE   677,859 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 530 997,627 SH   SOLE   997,627 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 837 510,126 SH   SOLE   510,126 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 319 104,741 SH   SOLE   104,741 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 585 527,462 SH   SOLE   527,462 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 1,047 316,939 SH   SOLE   316,939 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 553 221,252 SH   SOLE   221,252 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 1,429 362,537 SH   SOLE   362,537 0 0
ENVERIC BIOSCIENCES INC COM NEW 29405E109 141 423,834 SH   SOLE   423,834 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 274 22,552 SH   SOLE   22,552 0 0
FATE THERAPEUTICS INC COM 31189P102 374 9,640 SH   SOLE   9,640 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 1,662 330,523 SH   SOLE   330,523 0 0
GALAPAGOS NV SPON ADR 36315X101 5,413 86,865 SH   SOLE   86,865 0 0
GAMIDA CELL LTD SHS M47364100 135 32,689 SH   SOLE   32,689 0 0
GEMINI THERAPEUTICS INC COM 36870G105 615 443,096 SH   SOLE   443,096 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 259 206,336 SH   SOLE   206,336 0 0
GILEAD SCIENCES INC COM 375558103 10,779 181,300 SH Put SOLE   181,300 0 0
GILEAD SCIENCES INC COM 375558103 10,779 181,300 SH Call SOLE   181,300 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 1,732 49,997 SH   SOLE   49,997 0 0
GOSSAMER BIO INC COM 38341P102 1,836 211,600 SH Call SOLE   211,600 0 0
GOSSAMER BIO INC COM 38341P102 6,730 775,315 SH   SOLE   775,315 0 0
GOSSAMER BIO INC COM 38341P102 129 14,900 SH Put SOLE   14,900 0 0
HARPOON THERAPEUTICS INC COM 41358P106 582 117,009 SH   SOLE   117,009 0 0
HEPION PHARMACEUTICALS INC COM 426897104 751 582,137 SH   SOLE   582,137 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 16,633 158,100 SH Call SOLE   158,100 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 11,585 110,116 SH   SOLE   110,116 0 0
IGM BIOSCIENCES INC COM 449585108 43 1,587 SH   SOLE   1,587 0 0
IMMATICS N.V SHS N44445109 6,243 781,388 SH   SOLE   781,388 0 0
IMMUNIC INC COM 4525EP101 696 61,500 SH Put SOLE   61,500 0 0
IMMUNOPRECISE ANTIBODIES LTD COM NEW 45257F200 399 77,650 SH   SOLE   77,650 0 0
INFLARX NV COM N44821101 639 349,468 SH   SOLE   349,468 0 0
INHIBRX INC COM 45720L107 1,911 85,800 SH Call SOLE   85,800 0 0
INHIBRX INC COM 45720L107 3,516 157,842 SH   SOLE   157,842 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,445 47,408 SH   SOLE   47,408 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 572 35,149 SH   SOLE   35,149 0 0
INVENTIVA SA ADS 46124U107 178 15,579 SH   SOLE   15,579 0 0
IVERIC BIO INC COM 46583P102 825 49,099 SH   SOLE   49,099 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 586 39,730 SH   SOLE   39,730 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,340 50,000 SH   SOLE   50,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 6 830 SH   SOLE   830 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 18,001 1,083,116 SH   SOLE   1,083,116 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 4,666 280,800 SH Call SOLE   280,800 0 0
KINNATE BIOPHARMA INC COM 49705R105 22 1,990 SH   SOLE   1,990 0 0
KODIAK SCIENCES INC COM 50015M109 565 73,100 SH Put SOLE   73,100 0 0
KODIAK SCIENCES INC COM 50015M109 199 25,700 SH Call SOLE   25,700 0 0
KODIAK SCIENCES INC COM 50015M109 526 68,100 SH   SOLE   68,100 0 0
KYMERA THERAPEUTICS INC COM 501575104 2,117 50,000 SH   SOLE   50,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 209 51,606 SH   SOLE   51,606 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 1,751 243,904 SH   SOLE   243,904 0 0
LYRA THERAPEUTICS INC COM 55234L105 1,698 422,338 SH   SOLE   422,338 0 0
MACROGENICS INC COM 556099109 1,446 164,119 SH   SOLE   164,119 0 0
MAXCYTE INC COM 57777K106 964 137,958 SH   SOLE   137,958 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 318 915,856 SH   SOLE   915,856 0 0
MERUS N V COM N5749R100 1,420 53,703 SH   SOLE   53,703 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 12,383 1,928,752 SH   SOLE   1,928,752 0 0
MIND MEDICINE MINDMED INC COM SUB VTG 60255C109 118 105,958 SH   SOLE   105,958 0 0
MUSTANG BIO INC COM 62818Q104 551 546,824 SH   SOLE   546,824 0 0
MYMD PHARMACEUTICALS INC COM 62856X102 612 131,389 SH   SOLE   131,389 0 0
NEKTAR THERAPEUTICS COM 640268108 722 133,900 SH Call SOLE   133,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 40,277 429,600 SH Call SOLE   429,600 0 0
NEUROSENSE THERAPEUTICS LTD ORDINARY SHARES M74240108 397 100,000 SH   SOLE   100,000 0 0
NEXTCURE INC COM 65343E108 686 141,058 SH   SOLE   141,058 0 0
NOVAVAX INC COM NEW 670002401 100 1,362 SH   SOLE   1,362 0 0
NUVATION BIO INC COM CL A 67080N101 1,122 213,310 SH   SOLE   213,310 0 0
OCULAR THERAPEUTIX INC COM 67576A100 147 29,644 SH   SOLE   29,644 0 0
OCUPHIRE PHARMA INC COM 67577R102 401 124,021 SH   SOLE   124,021 0 0
ONCONOVA THERAPEUTICS INC COM NEW 68232V801 35 18,975 SH   SOLE   18,975 0 0
ONCTERNAL THERAPEUTICS INC COM 68236P107 292 210,182 SH   SOLE   210,182 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 110 155,606 SH   SOLE   155,606 0 0
OTONOMY INC COM 68906L105 525 218,538 SH   SOLE   218,538 0 0
OVID THERAPEUTICS INC COM 690469101 2,319 738,372 SH   SOLE   738,372 0 0
PANBELA THERAPEUTICS INC COM 69833Q100 750 355,959 SH   SOLE   355,959 0 0
PARDES BIOSCIENCES INC COM 69945Q105 2,338 323,934 SH   SOLE   323,934 0 0
PASSAGE BIO INC COM 702712100 223 71,856 SH   SOLE   71,856 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 22 3,672 SH   SOLE   3,672 0 0
PFIZER INC COM 717081103 4,142 80,000 SH   SOLE   80,000 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 1,069 78,550 SH   SOLE   78,550 0 0
PLIANT THERAPEUTICS INC COM 729139105 636 90,805 SH   SOLE   90,805 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,082 100,000 SH Call SOLE   100,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,082 100,000 SH Put SOLE   100,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 3,806 160,700 SH Call SOLE   160,700 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 1,515 296,426 SH   SOLE   296,426 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 144 49,843 SH   SOLE   49,843 0 0
QUANTUM SI INC COM CL A 74765K105 736 157,363 SH   SOLE   157,363 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 502 15,300 SH Call SOLE   15,300 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 2,846 86,905 SH   SOLE   86,905 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 21,281 649,600 SH Put SOLE   649,600 0 0
REGULUS THERAPEUTICS INC COM NEW 75915K200 384 1,289,130 SH   SOLE   1,289,130 0 0
RELMADA THERAPEUTICS INC COM 75955J402 588 21,801 SH   SOLE   21,801 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 546 185,597 SH   SOLE   185,597 0 0
RENOVACOR INC COM 75989E106 1,456 343,283 SH   SOLE   343,283 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 6,390 2,137,128 SH   SOLE   2,137,128 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,275 250,000 SH Call SOLE   250,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,272 249,907 SH   SOLE   249,907 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 2,482 653,448 SH   SOLE   653,448 0 0
SAVARA INC COM 805111101 2,126 1,622,552 SH   SOLE   1,622,552 0 0
SCPHARMACEUTICALS INC COM 810648105 5,510 970,098 SH   SOLE   970,098 0 0
SEELOS THERAPEUTICS INC COM 81577F109 215 257,883 SH   SOLE   257,883 0 0
SERES THERAPEUTICS INC COM 81750R102 5,986 840,624 SH   SOLE   840,624 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 6,983 217,915 SH   SOLE   217,915 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 29 128,454 SH   SOLE   128,454 0 0
SOLID BIOSCIENCES INC COM 83422E105 625 521,155 SH   SOLE   521,155 0 0
SPDR SER TR S&P BIOTECH 78464A870 84,092 935,600 SH Call SOLE   935,600 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 350 501,836 SH   SOLE   501,836 0 0
SYNAPTOGENIX INC COM NEW 87167T201 1,186 153,226 SH   SOLE   153,226 0 0
SYNLOGIC INC COM 87166L100 1,248 519,775 SH   SOLE   519,775 0 0
TANGO THERAPEUTICS INC COM 87583X109 42 5,456 SH   SOLE   5,456 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 210 61,827 SH   SOLE   61,827 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 596 735,097 SH   SOLE   735,097 0 0
TG THERAPEUTICS INC COM 88322Q108 21 2,292 SH   SOLE   2,292 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 7,477 2,843,232 SH   SOLE   2,843,232 0 0
TRICIDA INC COM 89610F101 764 92,900 SH Put SOLE   92,900 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 17,942 100,000 SH Call SOLE   100,000 0 0
VALLON PHARMACEUTICALS INC COM 92023M101 380 201,758 SH   SOLE   201,758 0 0
VASCULAR BIOGENICS LTD COM M96883109 1,404 830,747 SH   SOLE   830,747 0 0
VAXCYTE INC COM 92243G108 7,630 315,991 SH   SOLE   315,991 0 0
VERASTEM INC COM 92337C104 956 678,023 SH   SOLE   678,023 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 6,524 25,000 SH   SOLE   25,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,596 532,429 SH   SOLE   532,429 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 633 511,186 SH   SOLE   511,186 0 0
VTV THERAPEUTICS INC CL A 918385105 536 742,980 SH   SOLE   742,980 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,095 1,048,039 SH   SOLE   1,048,039 0 0
X4 PHARMACEUTICALS INC COM 98420X103 2,402 1,372,022 SH   SOLE   1,372,022 0 0
XENON PHARMACEUTICALS INC COM 98420N105 7,320 239,441 SH   SOLE   239,441 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 355 236,284 SH   SOLE   236,284 0 0
ZAI LAB LTD ADR 98887Q104 376 81,843 SH   SOLE   81,843 0 0
ZAI LAB LTD ADR 98887Q104 2,336 53,100 SH Call SOLE   53,100 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 9,329 202,203 SH   SOLE   202,203 0 0