The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AADI BIOSCIENCE INC COM 00032Q104 1,274 412,343 SH   SOLE   412,343 0 0
ADICET BIO INC COM 007002108 2,091 143,214 SH   SOLE   143,214 0 0
AILERON THERAPEUTICS INC COM 00887A105 752 2,892,316 SH   SOLE   2,892,316 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,496 375,000 SH   SOLE   375,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 42,486 291,300 SH Call SOLE   291,300 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,931 61,237 SH   SOLE   61,237 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 5,820 39,900 SH Put SOLE   39,900 0 0
ALTAMIRA THERAPEUTICS LTD SHS G0360L100 36 75,000 SH   SOLE   75,000 0 0
ALTIMMUNE INC COM NEW 02155H200 3,553 303,600 SH Call SOLE   303,600 0 0
ALTIMMUNE INC COM NEW 02155H200 10,499 897,359 SH   SOLE   897,359 0 0
AMGEN INC COM 031162100 24,330 100,000 SH Call SOLE   100,000 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 6,757 350,800 SH Call SOLE   350,800 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 4,750 246,554 SH   SOLE   246,554 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103 942 181,199 SH   SOLE   181,199 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 5,572 123,200 SH Call SOLE   123,200 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,894 41,900 SH   SOLE   41,900 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,266 50,000 SH Put SOLE   50,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 588 23,200 SH Call SOLE   23,200 0 0
ARDELYX INC COM 039697107 991 1,680,552 SH   SOLE   1,680,552 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 185 970,747 SH   SOLE   970,747 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 1,776 592,123 SH   SOLE   592,123 0 0
ATHIRA PHARMA INC COM 04746L104 2,393 784,200 SH Call SOLE   784,200 0 0
ATHIRA PHARMA INC COM 04746L104 609 199,500 SH Put SOLE   199,500 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 912 322,217 SH   SOLE   322,217 0 0
AXSOME THERAPEUTICS INC COM 05464T104 19,151 500,000 SH Put SOLE   500,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 13,404 350,000 SH Call SOLE   350,000 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 759 697,316 SH   SOLE   697,316 0 0
BAUDAX BIO INC COM NEW 07160F206 3 2,966 SH   SOLE   2,966 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 617 523,348 SH   SOLE   523,348 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 924 100,000 SH Call SOLE   100,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 9,409 1,018,327 SH   SOLE   1,018,327 0 0
BIOGEN INC COM 09062X103 22,880 112,200 SH Call SOLE   112,200 0 0
BIOGEN INC COM 09062X103 228 1,122 SH   SOLE   1,122 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,843 106,700 SH Call SOLE   106,700 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,972 60,000 SH   SOLE   60,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 3,232 64,000 SH Call SOLE   64,000 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 698 253,432 SH   SOLE   253,432 0 0
BRIDGEBIO PHARMA INC COM 10806X102 1,817 200,000 SH Call SOLE   200,000 0 0
BRIGHT MINDS BIOSCIENCES INC COM 10919W108 86 105,958 SH   SOLE   105,958 0 0
CABALETTA BIO INC COM 12674W109 1,000 944,431 SH   SOLE   944,431 0 0
CASI PHARMACEUTICALS INC COM NEW 14757U208 378 132,014 SH   SOLE   132,014 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 16,628 616,700 SH Put SOLE   616,700 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 14,504 537,958 SH   SOLE   537,958 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 13,656 506,500 SH Call SOLE   506,500 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 992 268,104 SH   SOLE   268,104 0 0
CHIMERIX INC COM 16934W106 917 441,203 SH   SOLE   441,203 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 0 332,295 SH   SOLE   332,295 0 0
CLENE INC COMMON STOCK 185634102 177 70,000 SH   SOLE   70,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 761 422,339 SH   SOLE   422,339 0 0
COGENT BIOSCIENCES INC COM 19240Q201 2,256 250,000 SH   SOLE   250,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 591 677,859 SH   SOLE   677,859 0 0
CONTRAFECT CORP COM NEW 212326300 615 200,000 SH Put SOLE   200,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 217 862,527 SH   SOLE   862,527 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 113 104,741 SH   SOLE   104,741 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 1,401 316,939 SH   SOLE   316,939 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 884 362,537 SH   SOLE   362,537 0 0
ENVERIC BIOSCIENCES INC COM NEW 29405E109 48 223,834 SH   SOLE   223,834 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 13,067 2,054,602 SH   SOLE   2,054,602 0 0
EVOLUS INC COM 30052C107 529 45,516 SH   SOLE   45,516 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 938 330,523 SH   SOLE   330,523 0 0
FULCRUM THERAPEUTICS INC COM 359616109 893 182,200 SH Call SOLE   182,200 0 0
GALAPAGOS NV SPON ADR 36315X101 4,830 86,865 SH   SOLE   86,865 0 0
GEMINI THERAPEUTICS INC COM 36870G105 749 443,096 SH   SOLE   443,096 0 0
GOSSAMER BIO INC COM 38341P102 8,373 1,000,387 SH   SOLE   1,000,387 0 0
GOSSAMER BIO INC COM 38341P102 2,800 334,500 SH Call SOLE   334,500 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 4,196 86,035 SH   SOLE   86,035 0 0
HEPION PHARMACEUTICALS INC COM 426897104 235 410,189 SH   SOLE   410,189 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 12,771 160,116 SH   SOLE   160,116 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 7,976 100,000 SH Call SOLE   100,000 0 0
IMMATICS N.V SHS N44445109 1,369 157,190 SH   SOLE   157,190 0 0
IMMUNIC INC COM 4525EP101 214 61,500 SH   SOLE   61,500 0 0
IMMUNIC INC COM 4525EP101 213 61,500 SH Put SOLE   61,500 0 0
IMMUNOPRECISE ANTIBODIES LTD COM NEW 45257F200 237 61,433 SH   SOLE   61,433 0 0
INHIBRX INC COM 45720L107 561 49,372 SH   SOLE   49,372 0 0
INSMED INC COM PAR $.01 457669307 2,465 125,000 SH   SOLE   125,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,449 105,000 SH   SOLE   105,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 4,832 350,000 SH Call SOLE   350,000 0 0
INVENTIVA SA ADS 46124U107 93 15,579 SH   SOLE   15,579 0 0
ITEOS THERAPEUTICS INC COM 46565G104 2,061 100,000 SH Call SOLE   100,000 0 0
IVERIC BIO INC COM 46583P102 2,351 244,400 SH Call SOLE   244,400 0 0
IVERIC BIO INC COM 46583P102 473 49,099 SH   SOLE   49,099 0 0
KARUNA THERAPEUTICS INC COM 48576A100 12,652 100,000 SH Put SOLE   100,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100 12,651 100,000 SH   SOLE   100,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 8,894 1,075,300 SH Call SOLE   1,075,300 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 11,645 1,408,116 SH   SOLE   1,408,116 0 0
KRANESHARES TR CSI CHI INTERNET 500767306 3,277 100,000 SH   SOLE   100,000 0 0
LANTHEUS HLDGS INC COM 516544103 6,602 100,000 SH Call SOLE   100,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 100 51,606 SH   SOLE   51,606 0 0
LYRA THERAPEUTICS INC COM 55234L105 1,963 347,338 SH   SOLE   347,338 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 199 615,856 SH   SOLE   615,856 0 0
MERUS N V COM N5749R100 1,216 53,703 SH   SOLE   53,703 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 1,261 212,400 SH Call SOLE   212,400 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 8,194 1,379,422 SH   SOLE   1,379,422 0 0
MIND MEDICINE MINDMED INC COM SUB VTG 60255C109 68 105,958 SH   SOLE   105,958 0 0
MUSTANG BIO INC COM 62818Q104 145 246,824 SH   SOLE   246,824 0 0
MYMD PHARMACEUTICALS INC COM 62856X102 176 81,089 SH   SOLE   81,089 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,763 38,600 SH   SOLE   38,600 0 0
NEXTCURE INC COM 65343E108 336 71,435 SH   SOLE   71,435 0 0
OTONOMY INC COM 68906L105 0 180 SH   SOLE   180 0 0
OVID THERAPEUTICS INC COM 690469101 59 26,831 SH   SOLE   26,831 0 0
PARDES BIOSCIENCES INC COM 69945Q105 687 223,934 SH   SOLE   223,934 0 0
PFIZER INC COM 717081103 4,194 80,000 SH   SOLE   80,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 263 107,200 SH Call SOLE   107,200 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 756 257,853 SH   SOLE   257,853 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 632 20,805 SH   SOLE   20,805 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 4,923 162,000 SH Call SOLE   162,000 0 0
REGULUS THERAPEUTICS INC COM 75915K309 217 105,341 SH   SOLE   105,341 0 0
RELMADA THERAPEUTICS INC COM 75955J402 5,698 300,000 SH Call SOLE   300,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 5,362 282,300 SH Put SOLE   282,300 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 491 185,597 SH   SOLE   185,597 0 0
RENOVACOR INC COM 75989E106 595 293,283 SH   SOLE   293,283 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 794 702,773 SH   SOLE   702,773 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,075 250,000 SH Call SOLE   250,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 7,495 100,000 SH Call SOLE   100,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,874 25,000 SH   SOLE   25,000 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 2,704 653,448 SH   SOLE   653,448 0 0
SCPHARMACEUTICALS INC COM 810648105 4,261 884,008 SH   SOLE   884,008 0 0
SERES THERAPEUTICS INC COM 81750R102 1,854 540,624 SH   SOLE   540,624 0 0
SPDR SER TR S&P BIOTECH 78464A870 25,994 350,000 SH Put SOLE   350,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 127 501,836 SH   SOLE   501,836 0 0
SYNAPTOGENIX INC COM NEW 87167T201 614 121,191 SH   SOLE   121,191 0 0
SYNLOGIC INC COM 87166L100 545 474,360 SH   SOLE   474,360 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 132 61,827 SH   SOLE   61,827 0 0
TERNS PHARMACEUTICALS INC COM 880881107 1,736 700,000 SH   SOLE   700,000 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 5,577 2,788,853 SH   SOLE   2,788,853 0 0
TRICIDA INC COM 89610F101 899 92,900 SH Put SOLE   92,900 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 9,426 40,000 SH   SOLE   40,000 0 0
VASCULAR BIOGENICS LTD COM M96883109 1,337 830,007 SH   SOLE   830,007 0 0
VAXCYTE INC COM 92243G108 4,918 225,991 SH   SOLE   225,991 0 0
VERASTEM INC COM 92337C104 265 228,023 SH   SOLE   228,023 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 200 300,000 SH   SOLE   300,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 11,271 40,000 SH   SOLE   40,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 2,414 835,275 SH   SOLE   835,275 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 3,472 300,000 SH Call SOLE   300,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 318 98,039 SH   SOLE   98,039 0 0
X4 PHARMACEUTICALS INC COM 98420X103 1,621 1,679,748 SH   SOLE   1,679,748 0 0
XENON PHARMACEUTICALS INC COM 98420N105 7,283 239,441 SH   SOLE   239,441 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 190 104,392 SH   SOLE   104,392 0 0
ZAI LAB LTD ADR 98887Q104 278 81,843 SH   SOLE   81,843 0 0