The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABSCI CORPORATION COM 00091E109 2,969 894,346 SH   SOLE   894,346 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 4,764 341,239 SH   SOLE   341,239 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 2,390 508,532 SH   SOLE   508,532 0 0
ADMA BIOLOGICS INC COM 000899104 22,812 11,521,102 SH   SOLE   11,521,102 0 0
AGILE THERAPEUTICS INC COM NEW 00847L209 620 532,361 SH   SOLE   532,361 0 0
ALBIREO PHARMA INC COM 01345P106 46,872 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 39,516 9,903,879 SH   SOLE   9,903,879 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 25,231 172,991 SH   SOLE   172,991 0 0
AMICUS THERAPEUTICS INC COM 03152W109 288,858 26,895,532 SH   SOLE   26,895,532 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 68,188 3,540,408 SH   SOLE   3,540,408 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 14,529 321,300 SH   SOLE   321,300 0 0
ARCELLX INC COMMON STOCK 03940C100 20,647 1,141,990 SH   SOLE   1,141,990 0 0
ARTIVION INC COM 228903100 17,553 929,705 SH   SOLE   929,705 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 3,843 1,281,197 SH   SOLE   1,281,197 0 0
ATHENEX INC COM 04685N103 5,540 13,532,467 SH   SOLE   13,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 14,632 4,797,278 SH   SOLE   4,797,278 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 51,136 5,534,169 SH   SOLE   5,534,169 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 14,917 180,000 SH   SOLE   180,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 15,409 1,697,033 SH   SOLE   1,697,033 0 0
C4 THERAPEUTICS INC COM STK 12529R107 5,777 766,231 SH   SOLE   766,231 0 0
CAREMAX INC COM CL A 14171W103 10,890 3,000,000 SH   SOLE   3,000,000 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 43 60,000 SH   SOLE   60,000 0 0
CASSAVA SCIENCES INC COM 14817C107 2,812 100,000 SH Put SOLE   100,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 134,493 5,086,727 SH   SOLE   5,086,727 0 0
CHEMOCENTRYX INC COM 16383L106 10,945 441,680 SH   SOLE   441,680 0 0
CINCOR PHARMA INC COM 17240Y109 43,692 2,319,117 SH   SOLE   2,319,117 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 3,210 1,500,000 SH   SOLE   1,500,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 27,863 3,088,972 SH   SOLE   3,088,972 0 0
COHERUS BIOSCIENCES INC COM 19249H103 26,393 3,645,471 SH   SOLE   3,645,471 0 0
COHERUS BIOSCIENCES INC NOTE 1.500% 4/1 19249HAB9 29,484 4,500,000 PRN   SOLE   4,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 9,054 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 99,237 5,321,032 SH   SOLE   5,321,032 0 0
DARIOHEALTH CORP COM NEW 23725P209 2,013 327,869 SH   SOLE   327,869 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 9,953 556,047 SH   SOLE   556,047 0 0
DICE THERAPEUTICS INC COM 23345J104 16,326 1,051,904 SH   SOLE   1,051,904 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106 2,954 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115 203 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 22,065 405,759 SH   SOLE   405,759 0 0
FERRARI N V COM N3167Y103 1,138 6,200 SH   SOLE   6,200 0 0
FULCRUM THERAPEUTICS INC COM 359616109 1,441 294,118 SH   SOLE   294,118 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 2,621 1,052,445 SH   SOLE   1,052,445 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 96,331 3,015,054 SH   SOLE   3,015,054 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 20,084 411,804 SH   SOLE   411,804 0 0
HEALTH CATALYST INC COM 42225T107 6,740 465,162 SH   SOLE   465,162 0 0
HILLEVAX INC COM 43157M102 8,360 764,907 SH   SOLE   764,907 0 0
HYPERFINE INC COM CL A 44916K106 2,530 1,134,388 SH   SOLE   1,134,388 0 0
ICOSAVAX INC COM 45114M109 5,976 1,042,850 SH   SOLE   1,042,850 0 0
IMMATICS N.V SHS N44445109 21,775 2,500,000 SH   SOLE   2,500,000 0 0
INHIBRX INC COM 45720L107 21,731 1,914,592 SH   SOLE   1,914,592 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 130,562 11,826,299 SH   SOLE   11,826,299 0 0
ISOPLEXIS CORP COM 465005106 8,846 4,095,498 SH   SOLE   4,095,498 0 0
IVERIC BIO INC COM 46583P102 20,086 2,087,956 SH   SOLE   2,087,956 0 0
KRONOS BIO INC COM 50107A104 8,812 2,421,142 SH   SOLE   2,421,142 0 0
LANDOS BIOPHARMA INC COM 515069102 10,823 14,869,915 SH   SOLE   14,869,915 0 0
LEAP THERAPEUTICS INC COM 52187K101 9,144 7,951,448 SH   SOLE   7,951,448 0 0
LIANBIO SPONSORED ADS 53000N108 122,170 56,560,211 SH   SOLE   56,560,211 0 0
LILLY ELI & CO COM 532457108 32,423 100,000 SH   SOLE   100,000 0 0
LYRA THERAPEUTICS INC COM 55234L105 51,679 9,146,730 SH   SOLE   9,146,730 0 0
MACROGENICS INC COM 556099109 3,620 1,227,202 SH   SOLE   1,227,202 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 26,306 367,501 SH   SOLE   367,501 0 0
MEIRAGTX HLDGS PLC COM G59665102 52,712 6,963,277 SH   SOLE   6,963,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105 192,453 2,866,863 SH   SOLE   2,866,863 0 0
MORPHIC HLDG INC COM 61775R105 7,881 363,197 SH   SOLE   363,197 0 0
MOTUS GI HLDGS INC COM 62014P108 507 1,800,542 SH   SOLE   1,800,542 0 0
NANOBIOTIX SPONSORED ADS 63009J107 4,027 1,059,800 SH   SOLE   1,059,800 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 24,508 9,111,151 SH   SOLE   9,111,151 0 0
NEPTUNE WELLNESS SOLUTIONS I COM NEW 64079L204 81 57,142 SH   SOLE   57,142 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 38,786 397,888 SH   SOLE   397,888 0 0
NUVALENT INC COM 670703107 22,442 1,655,007 SH   SOLE   1,655,007 0 0
NUVATION BIO INC COM CL A 67080N101 5,733 1,769,701 SH   SOLE   1,769,701 0 0
OUTSET MED INC COM 690145107 14,841 998,727 SH   SOLE   998,727 0 0
PEAR THERAPEUTICS INC CLASS A COM 704723105 1,386 900,548 SH   SOLE   900,548 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 7,314 1,073,995 SH   SOLE   1,073,995 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 7,962 273,423 SH   SOLE   273,423 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 24,508 749,700 SH   SOLE   749,700 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 47,490 1,682,242 SH   SOLE   1,682,242 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 850 290,051 SH   SOLE   290,051 0 0
PROVENTION BIO INC COM 74374N102 443 110,728 SH   SOLE   110,728 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 3,639 1,528,812 SH   SOLE   1,528,812 0 0
QUOTIENT LTD SHS G73268107 3,888 16,200,818 SH   SOLE   16,200,818 0 0
RAIN THERAPEUTICS INC COM 75082Q105 13,809 2,483,619 SH   SOLE   2,483,619 0 0
RAPT THERAPEUTICS INC COM 75382E109 34,927 1,913,791 SH   SOLE   1,913,791 0 0
RELAY THERAPEUTICS INC COM 75943R102 32,546 1,943,097 SH   SOLE   1,943,097 0 0
RELMADA THERAPEUTICS INC COM 75955J402 2,304 121,350 SH   SOLE   121,350 0 0
REVANCE THERAPEUTICS INC COM 761330109 7,912 572,514 SH   SOLE   572,514 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 16,056 1,166,883 SH   SOLE   1,166,883 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 3,015 1,500,000 SH   SOLE   1,500,000 0 0
SEAGEN INC COM 81181C104 39,635 224,000 SH   SOLE   224,000 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 6,300 5,000,000 SH   SOLE   5,000,000 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 13,509 3,536,274 SH   SOLE   3,536,274 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,257 13,412,552 SH   SOLE   13,412,552 0 0
SOMALOGIC INC CLASS A COM 83444K105 6,780 1,500,000 SH   SOLE   1,500,000 0 0
SONENDO INC COM 835431107 1,115 648,505 SH   SOLE   648,505 0 0
SPDR SER TR S&P BIOTECH 78464A870 7,427 100,000 SH Put SOLE   100,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 95,217 3,867,446 SH   SOLE   3,867,446 0 0
SURROZEN INC COM 86889P109 18 6,017 SH   SOLE   6,017 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 32 166,666 SH   SOLE   166,666 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 18,927 1,296,416 SH   SOLE   1,296,416 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 13,813 570,084 SH   SOLE   570,084 0 0
TRAVERE THERAPEUTICS INC NOTE 2.250% 3/0 89422GAA5 455,940 45,000,000 PRN   SOLE   45,000,000 0 0
TREACE MED CONCEPTS INC COM 89455T109 13,497 941,192 SH   SOLE   941,192 0 0
TYRA BIOSCIENCES INC COM 90240B106 3,535 494,403 SH   SOLE   494,403 0 0
VBI VACCINES INC CDA COM NEW 91822J103 42,312 52,335,002 SH   SOLE   52,335,002 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 12,214 2,915,146 SH   SOLE   2,915,146 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 9,675 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103 39,550 3,500,000 SH   SOLE   3,500,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 11,244 971,832 SH   SOLE   971,832 0 0
XENON PHARMACEUTICALS INC COM 98420N105 64,568 2,122,535 SH   SOLE   2,122,535 0 0
Y-MABS THERAPEUTICS INC COM 984241109 3,208 212,018 SH   SOLE   212,018 0 0
ZYMERGEN INC COM 98985X100 1,086 883,332 SH   SOLE   883,332 0 0
ZYMEWORKS INC COM 98985W102 21,902 4,132,534 SH   SOLE   4,132,534 0 0