The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,448 250,000 SH   SOLE   250,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 8,559 543,776 SH   SOLE   543,776 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 4,213 420,000 SH   SOLE   420,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 10,215 300,000 SH   SOLE   300,000 0 0
ALLAKOS INC COM 01671P100 2,448 400,000 SH   SOLE   400,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 6,514 32,545 SH   SOLE   32,545 0 0
ALTIMMUNE INC COM NEW 02155H200 1,283 100,469 SH   SOLE   100,469 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 1,303 188,300 SH   SOLE   188,300 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 1,032 100,000 SH Call SOLE   100,000 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 9,727 942,500 SH Put SOLE   942,500 0 0
APOLLO ENDOSURGERY INC COM 03767D108 6,260 1,136,206 SH   SOLE   1,136,206 0 0
ARVINAS INC COM 04335A105 1,813 40,741 SH   SOLE   40,741 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 516 5,000 SH   SOLE   5,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 17,485 1,655,775 SH   SOLE   1,655,775 0 0
BIOATLA INC COM 09077B104 1,543 200,422 SH   SOLE   200,422 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,351 186,603 SH   SOLE   186,603 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 1,498 53,275 SH   SOLE   53,275 0 0
CERUS CORP COM 157085101 5,819 1,616,459 SH   SOLE   1,616,459 0 0
CLENE INC COMMON STOCK 185634102 4,857 1,734,800 SH Put SOLE   1,734,800 0 0
CODEXIS INC COM 192005106 881 145,437 SH   SOLE   145,437 0 0
COGENT BIOSCIENCES INC COM 19240Q201 9,051 606,608 SH   SOLE   606,608 0 0
COMPASS THERAPEUTICS INC COM 20454B104 598 262,090 SH   SOLE   262,090 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 2,927 149,027 SH   SOLE   149,027 0 0
CTI BIOPHARMA CORP COM 12648L601 5,724 983,516 SH   SOLE   983,516 0 0
CULLINAN ONCOLOGY INC COM 230031106 2,879 224,555 SH   SOLE   224,555 0 0
CVRX INC COM 126638105 2,873 307,920 SH   SOLE   307,920 0 0
ELIEM THERAPEUTICS INC COM 28658R106 1,299 402,088 SH   SOLE   402,088 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 187 1,098,469 SH   SOLE   1,098,469 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 2,104 314,095 SH   SOLE   314,095 0 0
EVOGENE LTD SHS M4119S104 139 167,510 SH   SOLE   167,510 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 857 108,285 SH   SOLE   108,285 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 627 10,131 SH   SOLE   10,131 0 0
IMMATICS N.V SHS N44445109 1,639 163,938 SH   SOLE   163,938 0 0
IMMUNOGEN INC COM 45253H101 2,097 438,695 SH   SOLE   438,695 0 0
IMMUNOVANT INC COM 45258J102 1,674 300,000 SH   SOLE   300,000 0 0
INSMED INC COM PAR $.01 457669307 4,825 224,016 SH   SOLE   224,016 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,791 32,011 SH   SOLE   32,011 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 6,334 136,126 SH   SOLE   136,126 0 0
IVERIC BIO INC COM 46583P102 7,949 443,100 SH Put SOLE   443,100 0 0
IVERIC BIO INC COM 46583P102 3,182 177,364 SH   SOLE   177,364 0 0
KARUNA THERAPEUTICS INC COM 48576A100 2,322 10,323 SH   SOLE   10,323 0 0
KRYSTAL BIOTECH INC COM 501147102 3,948 56,645 SH   SOLE   56,645 0 0
LAVA THERAPEUTICS NV SHS N51517105 2,791 610,809 SH   SOLE   610,809 0 0
MACROGENICS INC COM 556099109 346 100,000 SH   SOLE   100,000 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 1 49,990 SH   SOLE   49,990 0 0
MEIRAGTX HLDGS PLC COM G59665102 465 55,342 SH   SOLE   55,342 0 0
MERSANA THERAPEUTICS INC COM 59045L106 6,720 994,073 SH   SOLE   994,073 0 0
MERUS N V COM N5749R100 5,912 295,136 SH   SOLE   295,136 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,968 42,500 SH Call SOLE   42,500 0 0
MIRATI THERAPEUTICS INC COM 60468T105 714 10,220 SH   SOLE   10,220 0 0
MORPHIC HLDG INC COM 61775R105 9,181 324,421 SH   SOLE   324,421 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,236 94,517 SH   SOLE   94,517 0 0
NKARTA INC COM 65487U108 4,769 362,377 SH   SOLE   362,377 0 0
NUCANA PLC SPONSORED ADR 67022C106 282 269,682 SH   SOLE   269,682 0 0
NUVALENT INC COM 670703107 806 41,439 SH   SOLE   41,439 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 3,869 1,208,992 SH   SOLE   1,208,992 0 0
PHREESIA INC COM 71944F106 2,123 83,305 SH   SOLE   83,305 0 0
PLIANT THERAPEUTICS INC COM 729139105 4,383 209,822 SH   SOLE   209,822 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 2,319 300,000 SH   SOLE   300,000 0 0
POLYPID LTD SHS M8001Q118 59 50,000 SH Put SOLE   50,000 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 9,017 2,554,277 SH   SOLE   2,554,277 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 227 100,000 SH   SOLE   100,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 12,079 204,700 SH Put SOLE   204,700 0 0
PROTHENA CORP PLC SHS G72800108 6,669 110,000 SH   SOLE   110,000 0 0
PROTHENA CORP PLC SHS G72800108 303 5,000 SH Put SOLE   5,000 0 0
REGENXBIO INC COM 75901B107 2,910 110,085 SH   SOLE   110,085 0 0
RELMADA THERAPEUTICS INC COM 75955J402 14,549 393,000 SH Put SOLE   393,000 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 8 104,828 SH   SOLE   104,828 0 0
SEAGEN INC COM 81181C104 1,454 10,627 SH   SOLE   10,627 0 0
SERES THERAPEUTICS INC COM 81750R102 2,353 366,493 SH   SOLE   366,493 0 0
STEREOTAXIS INC COM NEW 85916J409 623 346,231 SH   SOLE   346,231 0 0
TERNS PHARMACEUTICALS INC COM 880881107 85 14,473 SH   SOLE   14,473 0 0
TREVI THERAPEUTICS INC COM 89532M101 1,446 939,265 SH   SOLE   939,265 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 2,240 10,696 SH   SOLE   10,696 0 0
VERACYTE INC COM 92337F107 11,053 665,854 SH   SOLE   665,854 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3,215 11,105 SH   SOLE   11,105 0 0
VERU INC COM 92536C103 6,336 550,000 SH Put SOLE   550,000 0 0
VIEWRAY INC COM 92672L107 8,460 2,324,066 SH   SOLE   2,324,066 0 0
XENON PHARMACEUTICALS INC COM 98420N105 8,880 245,992 SH   SOLE   245,992 0 0