The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 13,727 141,871 SH   SOLE   86,185 0 55,686
ABBOTT LABS COM 002824100 1,843 19,050 SH   OTR   19,050 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 17,768 69,054 SH   SOLE   29,133 0 39,921
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 12,965 1,820,895 SH   SOLE   685,725 0 1,135,170
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 523 73,500 SH   OTR   73,500 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 413 1,500 SH   SOLE   1,500 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,431 5,200 SH   OTR   5,200 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 7,992 57,007 SH   SOLE   26,455 0 30,552
ALPHABET INC CAP STK CL A 02079K305 73,600 769,470 SH   SOLE   242,400 0 527,070
ALPHABET INC CAP STK CL C 02079K107 18,718 194,675 SH   SOLE   3,020 0 191,655
AMAZON COM INC COM 023135106 78,307 692,981 SH   SOLE   157,796 0 535,185
AMAZON COM INC COM 023135106 1,548 13,700 SH   OTR   13,700 0 0
AMERICAN TOWER CORP NEW COM 03027X100 8,588 40,000 SH   OTR   40,000 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 5,621 43,185 SH   SOLE   43,185 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 234 1,800 SH   OTR   1,800 0 0
AMERIPRISE FINL INC COM 03076C106 21,041 83,512 SH   SOLE   34,955 0 48,557
AMETEK INC COM 031100100 9,812 86,516 SH   SOLE   86,516 0 0
AMETEK INC COM 031100100 15,453 136,255 SH   OTR   136,255 0 0
APPLE INC COM 037833100 103,857 751,495 SH   SOLE   224,313 0 527,182
APPLE INC COM 037833100 3,469 25,100 SH   OTR   25,100 0 0
APPLIED MATLS INC COM 038222105 10,598 129,360 SH   SOLE   52,491 0 76,869
AVERY DENNISON CORP COM 053611109 11,568 71,103 SH   SOLE   46,295 0 24,808
BECTON DICKINSON & CO COM 075887109 18,301 82,131 SH   SOLE   36,099 0 46,032
BIO-TECHNE CORP COM 09073M104 29,951 105,460 SH   SOLE   24,057 0 81,403
BIO-TECHNE CORP COM 09073M104 6,710 23,625 SH   OTR   23,625 0 0
BK OF AMERICA CORP COM 060505104 7,772 257,357 SH   SOLE   257,357 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 7,498 105,475 SH   SOLE   105,475 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 4,806 67,600 SH   OTR   67,600 0 0
BROADCOM INC COM 11135F101 16,163 36,403 SH   SOLE   21,168 0 15,235
BROADCOM INC COM 11135F101 844 1,900 SH   OTR   1,900 0 0
CATALENT INC COM 148806102 13,476 186,237 SH   SOLE   71,637 0 114,600
CHART INDS INC COM 16115Q308 18,335 99,459 SH   SOLE   26,379 0 73,080
CHART INDS INC COM 16115Q308 258 1,400 SH   OTR   1,400 0 0
CHUBB LIMITED COM H1467J104 19,410 106,720 SH   SOLE   50,138 0 56,582
CIGNA CORP NEW COM 125523100 24,332 87,691 SH   SOLE   37,301 0 50,390
CIGNA CORP NEW COM 125523100 79 285 SH   OTR   285 0 0
COCA COLA CO COM 191216100 784 14,000 SH   OTR   14,000 0 0
CONSTELLATION BRANDS INC CL A 21036P108 503 2,188 SH   SOLE   2,188 0 0
CONSTELLATION BRANDS INC CL A 21036P108 184 800 SH   OTR   800 0 0
COOPER COS INC COM NEW 216648402 4,222 16,000 SH   OTR   16,000 0 0
COSTCO WHSL CORP NEW COM 22160K105 31,403 66,494 SH   SOLE   19,494 0 47,000
COSTCO WHSL CORP NEW COM 22160K105 588 1,245 SH   OTR   1,245 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 7,809 47,379 SH   SOLE   2,939 0 44,440
CROWDSTRIKE HLDGS INC CL A 22788C105 527 3,200 SH   OTR   3,200 0 0
DANAHER CORPORATION COM 235851102 258 1,000 SH   OTR   1,000 0 0
DARLING INGREDIENTS INC COM 237266101 48,475 732,807 SH   SOLE   164,624 0 568,183
DARLING INGREDIENTS INC COM 237266101 53 800 SH   OTR   800 0 0
DEXCOM INC COM 252131107 13,345 165,697 SH   SOLE   8,609 0 157,088
DISNEY WALT CO COM 254687106 10,185 107,967 SH   SOLE   50,488 0 57,479
DOLLAR GEN CORP NEW COM 256677105 23,142 96,482 SH   SOLE   25,182 0 71,300
DYNATRACE INC COM NEW 268150109 278 7,976 SH   SOLE   7,976 0 0
ENERGY RECOVERY INC COM 29270J100 326 15,000 SH   OTR   15,000 0 0
EXPEDIA GROUP INC COM NEW 30212P303 558 5,959 SH   SOLE   5,959 0 0
EXPEDIA GROUP INC COM NEW 30212P303 75 800 SH   OTR   800 0 0
EXXON MOBIL CORP COM 30231G102 22,306 255,482 SH   OTR   255,482 0 0
GENERAL MTRS CO COM 37045V100 14,138 440,569 SH   SOLE   185,887 0 254,682
GUARDANT HEALTH INC COM 40131M109 18,192 337,944 SH   SOLE   71,046 0 266,898
GUARDANT HEALTH INC COM 40131M109 2,325 43,200 SH   OTR   43,200 0 0
HALLIBURTON CO COM 406216101 2,619 106,393 SH   SOLE   106,393 0 0
HOME DEPOT INC COM 437076102 40,402 146,416 SH   SOLE   32,154 0 114,262
HOME DEPOT INC COM 437076102 648 2,350 SH   OTR   2,350 0 0
HONEYWELL INTL INC COM 438516106 6,620 39,649 SH   SOLE   39,649 0 0
HONEYWELL INTL INC COM 438516106 363 2,175 SH   OTR   2,175 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 9,804 158,414 SH   SOLE   6,912 0 151,502
HORIZON THERAPEUTICS PUB L SHS G46188101 62 1,000 SH   OTR   1,000 0 0
IDEXX LABS INC COM 45168D104 10,781 33,090 SH   SOLE   1,220 0 31,870
IDEXX LABS INC COM 45168D104 4,138 12,700 SH   OTR   12,700 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 16,499 182,607 SH   SOLE   76,367 0 106,240
INTERNATIONAL BUSINESS MACHS COM 459200101 285 2,400 SH   OTR   2,400 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 1,496 16,466 SH   OTR   16,466 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 9,617 1,003,849 SH   SOLE   37,941 0 965,908
IOVANCE BIOTHERAPEUTICS INC COM 462260100 123 12,800 SH   OTR   12,800 0 0
JOHNSON & JOHNSON COM 478160104 245 1,500 SH   OTR   1,500 0 0
JPMORGAN CHASE & CO COM 46625H100 22,297 213,372 SH   SOLE   82,609 0 130,763
JPMORGAN CHASE & CO COM 46625H100 9,622 92,080 SH   OTR   92,080 0 0
LAUDER ESTEE COS INC CL A 518439104 13,932 64,531 SH   SOLE   21,555 0 42,976
LOCKHEED MARTIN CORP COM 539830109 579 1,500 SH   OTR   1,500 0 0
MARRIOTT INTL INC NEW CL A 571903202 13,247 94,525 SH   SOLE   36,435 0 58,090
MERCK & CO INC COM 58933Y105 45,369 526,810 SH   OTR   526,810 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 2,800 45,885 SH   SOLE   45,885 0 0
MICROSOFT CORP COM 594918104 131,064 562,749 SH   SOLE   138,536 0 424,213
MICROSOFT CORP COM 594918104 12,006 51,550 SH   OTR   51,550 0 0
MSCI INC COM 55354G100 24,576 58,266 SH   SOLE   1,366 0 56,900
MURPHY OIL CORP COM 626717102 9,195 261,455 SH   OTR   261,455 0 0
MURPHY USA INC COM 626755102 11,385 41,413 SH   OTR   41,413 0 0
NEXTERA ENERGY INC COM 65339F101 20,323 259,190 SH   SOLE   93,883 0 165,307
NORFOLK SOUTHN CORP COM 655844108 37,282 177,828 SH   SOLE   50,845 0 126,983
NORFOLK SOUTHN CORP COM 655844108 328 1,565 SH   OTR   1,565 0 0
NORTHROP GRUMMAN CORP COM 666807102 884 1,880 SH   OTR   1,880 0 0
NVIDIA CORPORATION COM 67066G104 27,964 230,369 SH   SOLE   47,123 0 183,246
NVIDIA CORPORATION COM 67066G104 7,478 61,600 SH   OTR   61,600 0 0
NXP SEMICONDUCTORS N V COM N6596X109 14,825 100,502 SH   SOLE   4,862 0 95,640
OREILLY AUTOMOTIVE INC COM 67103H107 16,415 23,339 SH   SOLE   8,796 0 14,543
ORGANON & CO COMMON STOCK 68622V106 1,016 43,431 SH   OTR   43,431 0 0
PALO ALTO NETWORKS INC COM 697435105 541 3,300 SH   OTR   3,300 0 0
PARKER-HANNIFIN CORP COM 701094104 7,940 32,770 SH   OTR   32,770 0 0
PEPSICO INC COM 713448108 7,666 46,957 SH   SOLE   19,257 0 27,700
PHILLIPS 66 COM 718546104 7,731 95,781 SH   SOLE   95,781 0 0
POTLATCHDELTIC CORPORATION COM 737630103 6,224 151,661 SH   OTR   151,661 0 0
PROCTER AND GAMBLE CO COM 742718109 848 6,720 SH   OTR   6,720 0 0
PROLOGIS INC. COM 74340W103 26,614 261,945 SH   SOLE   31,393 0 230,552
PROLOGIS INC. COM 74340W103 152 1,500 SH   OTR   1,500 0 0
QUALCOMM INC COM 747525103 339 3,000 SH   OTR   3,000 0 0
ROPER TECHNOLOGIES INC COM 776696106 4,410 12,262 SH   SOLE   0 0 12,262
ROPER TECHNOLOGIES INC COM 776696106 12,724 35,380 SH   OTR   35,380 0 0
S&P GLOBAL INC COM 78409V104 1,142 3,740 SH   OTR   3,740 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,348 136,578 SH   SOLE   8,121 0 128,457
SAGE THERAPEUTICS INC COM 78667J108 779 19,900 SH   OTR   19,900 0 0
SALESFORCE INC COM 79466L302 216 1,500 SH   OTR   1,500 0 0
SERVICENOW INC COM 81762P102 29,515 78,162 SH   SOLE   16,590 0 61,572
SERVICENOW INC COM 81762P102 1,982 5,250 SH   OTR   5,250 0 0
SNOWFLAKE INC CL A 833445109 6,928 40,761 SH   SOLE   2,061 0 38,700
SPIRIT AEROSYSTEMS HLDGS INC COM CL A 848574109 2,437 111,173 SH   SOLE   111,173 0 0
SYNOPSYS INC COM 871607107 16,704 54,675 SH   SOLE   2,673 0 52,002
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 727 6,668 SH   SOLE   6,668 0 0
TE CONNECTIVITY LTD SHS H84989104 2,207 20,000 SH   OTR   20,000 0 0
TELEFLEX INCORPORATED COM 879369106 8,073 40,072 SH   SOLE   17,260 0 22,812
TELEFLEX INCORPORATED COM 879369106 1,128 5,600 SH   OTR   5,600 0 0
TENABLE HLDGS INC COM 88025T102 297 8,528 SH   SOLE   8,528 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 26,612 52,470 SH   SOLE   16,643 0 35,827
THERMO FISHER SCIENTIFIC INC COM 883556102 22,177 43,725 SH   OTR   43,725 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 34,029 234,993 SH   SOLE   42,125 0 192,868
TWILIO INC CL A 90138F102 5,143 74,381 SH   SOLE   3,216 0 71,165
TWILIO INC CL A 90138F102 297 4,300 SH   OTR   4,300 0 0
UNION PAC CORP COM 907818108 23,963 123,000 SH   OTR   123,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 11,048 21,875 SH   SOLE   1,255 0 20,620
VERTEX PHARMACEUTICALS INC COM 92532F100 503 1,737 SH   SOLE   1,737 0 0
VISA INC COM CL A 92826C839 52,045 292,962 SH   SOLE   45,539 0 247,423
VISA INC COM CL A 92826C839 1,688 9,500 SH   OTR   9,500 0 0
WEC ENERGY GROUP INC COM 92939U106 710 7,941 SH   OTR   7,941 0 0