The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102   4,014,346 526,817 SH   SOLE   498,188 0 28,629
ABSCI CORPORATION COM 00091E109   667,321 317,772 SH   SOLE   317,772 0 0
AC IMMUNE SA SHS H00263105   2,208,222 1,082,462 SH   SOLE   1,082,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   2,797,997 366,230 SH   SOLE   366,230 0 0
AFFIMED N V COM N01045108   718,122 579,131 SH   SOLE   579,131 0 0
ALBIREO PHARMA INC COM 01345P106   6,630,683 306,834 SH   SOLE   306,834 0 0
ALECTOR INC COM 014442107   1,676,989 181,689 SH   SOLE   181,689 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   116,037,345 1,317,259 SH   SOLE   1,162,467 0 154,792
ALLAKOS INC COM 01671P100   3,371,738 400,444 SH   SOLE   400,444 0 0
ALLISON TRANSMISSION HLDGS I COM 01973R101   80,954 1,946 SH   SOLE   1,946 0 0
ALLY FINL INC COM 02005N100   15,732,597 643,460 SH   SOLE   643,460 0 0
ALPHA TEKNOVA INC COM 02080L102   1,743,764 309,178 SH   SOLE   309,178 0 0
ALPHABET INC CAP STK CL A 02079K305   10,050,191 113,909 SH   SOLE   113,909 0 0
ALPHABET INC CAP STK CL C 02079K107   22,801,835 256,980 SH   SOLE   256,980 0 0
ALTIMMUNE INC COM NEW 02155H200   1,953,109 118,730 SH   SOLE   118,730 0 0
ANALOG DEVICES INC COM 032654105   2,976,324 18,145 SH   SOLE   18,145 0 0
APPLIED MATLS INC COM 038222105   2,107,693 21,644 SH   SOLE   21,644 0 0
ARCUS BIOSCIENCES INC COM 03969F109   3,202,319 154,851 SH   SOLE   154,851 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108   1,423,201 1,094,770 SH   SOLE   1,094,770 0 0
AT&T INC COM 00206R102   83,287 4,524 SH   SOLE   4,524 0 0
AZIYO BIOLOGICS INC CL A COM 05479K106   799,769 188,181 SH   SOLE   188,181 0 0
BALL CORP COM 058498106   157,613 3,082 SH   SOLE   3,082 0 0
BEST BUY INC COM 086516101   88,151 1,099 SH   SOLE   1,099 0 0
BIO RAD LABS INC CL A 090572207   8,498,523 20,211 SH   SOLE   20,211 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   1,549,674 134,989 SH   SOLE   134,989 0 0
BIOGEN INC COM 09062X103   6,409,036 23,144 SH   SOLE   23,144 0 0
BIONTECH SE SPONSORED ADS 09075V102   5,787,526 38,527 SH   SOLE   38,527 0 0
BLACK KNIGHT INC COM 09215C105   1,266,616 20,512 SH   SOLE   20,512 0 0
BLOCK INC CL A 852234103   13,598,450 216,398 SH   SOLE   216,398 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   1,745,478 39,842 SH   SOLE   39,842 0 0
BOOKING HOLDINGS INC COM 09857L108   101,602,356 50,416 SH   SOLE   42,641 0 7,775
CALIFORNIA RES CORP COM STOCK 13057Q305   89,413 2,055 SH   SOLE   2,055 0 0
CAMECO CORP COM 13321L108   27,291,884 1,204,061 SH   SOLE   1,204,061 0 0
CARMAX INC COM 143130102   92,796 1,524 SH   SOLE   1,524 0 0
CENTOGENE N V COM N1976T109   2,210,750 2,377,150 SH   SOLE   2,377,150 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108   143,100 422 SH   SOLE   422 0 0
CIENA CORP COM NEW 171779309   63,393,069 1,243,489 SH   SOLE   1,114,661 0 128,828
CIGNA CORP NEW COM 125523100   94,763 286 SH   SOLE   286 0 0
CISCO SYS INC COM 17275R102   597,167 12,535 SH   SOLE   12,535 0 0
COGENT BIOSCIENCES INC COM 19240Q201   5,911,668 511,390 SH   SOLE   486,557 0 24,833
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102   92,991 1,626 SH   SOLE   1,626 0 0
COHERUS BIOSCIENCES INC COM 19249H103   4,355,200 549,899 SH   SOLE   549,899 0 0
CORE LABORATORIES N V COM N22717107   286,415 14,130 SH   SOLE   14,130 0 0
CROWN HLDGS INC COM 228368106   122,493 1,490 SH   SOLE   1,490 0 0
CYTOMX THERAPEUTICS INC COM 23284F105   1,017,277 635,798 SH   SOLE   635,798 0 0
DENALI THERAPEUTICS INC COM 24823R105   1,539,033 55,341 SH   SOLE   55,341 0 0
DINGDONG CAYMAN LTD ADS 25445D101   37,138,560 8,697,555 SH   SOLE   8,557,286 0 140,269
DOORDASH INC CL A 25809K105   9,438,566 193,334 SH   SOLE   193,334 0 0
EBAY INC. COM 278642103   940,498 22,679 SH   SOLE   22,679 0 0
ERICSSON ADR B SEK 10 294821608   2,516,456 430,900 SH   SOLE   430,900 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   8,908,906 1,430,001 SH   SOLE   1,159,685 0 270,316
EXAGEN INC COM 30068X103   633,912 264,130 SH   SOLE   222,399 0 41,731
EXSCIENTIA PLC ADS 30223G102   21,511,528 4,035,934 SH   SOLE   3,999,777 0 36,157
FOX CORP CL A COM 35137L105   39,754 1,309 SH   SOLE   1,309 0 0
FREEPORT-MCMORAN INC CL B 35671D857   30,517,268 803,086 SH   SOLE   603,010 0 200,076
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108   1,592,728 199,091 SH   SOLE   199,091 0 0
GENERAL ELECTRIC CO COM NEW 369604301   73,373,646 875,685 SH   SOLE   583,113 0 292,572
GILEAD SCIENCES INC COM 375558103   69,019,880 803,959 SH   SOLE   583,338 0 220,621
H WORLD GROUP LTD SPONSORED ADS 44332N106   52,904,570 1,247,161 SH   SOLE   1,247,161 0 0
HANESBRANDS INC COM 410345102   94,993 14,936 SH   SOLE   14,936 0 0
HCA HEALTHCARE INC COM 40412C101   96,224 401 SH   SOLE   401 0 0
HELLO GROUP INC ADS 423403104   88,642 9,871 SH   SOLE   9,871 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101   73,165 4,917 SH   SOLE   4,917 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   3,552,979 240,391 SH   SOLE   240,391 0 0
ICOSAVAX INC COM 45114M109   17,862,705 2,249,711 SH   SOLE   2,095,181 0 154,530
IDEAYA BIOSCIENCES INC COM 45166A102   15,090,857 830,537 SH   SOLE   725,602 0 104,935
IMMATICS N.V SHS N44445109   2,336,118 268,211 SH   SOLE   268,211 0 0
IMMUNOVANT INC COM 45258J102   7,300,522 411,297 SH   SOLE   411,297 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303   302,757 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107   3,945,529 160,127 SH   SOLE   160,127 0 0
INTEL CORP COM 458140100   281,850 10,664 SH   SOLE   10,664 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104   93,769,312 914,020 SH   SOLE   769,248 0 144,772
IRIS ENERGY LTD ORDINARY SHARES Q4982L109   3,419,725 2,735,780 SH   SOLE   2,370,652 0 365,128
JD.COM INC SPON ADR CL A 47215P106   28,982,613 516,348 SH   SOLE   516,348 0 0
KRANESHARES TR CSI CHI INTERNET 500767306   5,451,100 180,500 SH   SOLE   180,500 0 0
KYNDRYL HLDGS INC COMMON STOCK 50155Q100   2,680 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108   6,160,757 14,658 SH   SOLE   14,658 0 0
LAREDO PETROLEUM INC COM 516806205   43,501 846 SH   SOLE   846 0 0
LEAP THERAPEUTICS INC COM 52187K101   597,578 1,327,952 SH   SOLE   1,327,952 0 0
LGI HOMES INC COM 50187T106   27,826,300 300,500 SH   SOLE   300,500 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854   914,634 15,300 SH   SOLE   15,300 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102   45,025 23,209 SH   SOLE   23,209 0 0
MATCH GROUP INC NEW COM 57667L107   7,902,434 190,466 SH   SOLE   190,466 0 0
MERSANA THERAPEUTICS INC COM 59045L106   1,701,146 290,298 SH   SOLE   290,298 0 0
MERUS N V COM N5749R100   2,960,262 191,355 SH   SOLE   191,355 0 0
META PLATFORMS INC CL A 30303M102   39,355,753 327,038 SH   SOLE   327,038 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104   236,242,671 3,362,885 SH   SOLE   2,859,150 0 503,735
MICRON TECHNOLOGY INC COM 595112103   116,759,378 2,336,122 SH   SOLE   2,061,459 0 274,663
MICROSOFT CORP COM 594918104   4,931,658 20,564 SH   SOLE   20,564 0 0
MODERNA INC COM 60770K107   3,682,210 20,500 SH   SOLE   20,500 0 0
MOSAIC CO NEW COM 61945C103   57,493,214 1,310,536 SH   SOLE   1,057,924 0 252,612
NANOSTRING TECHNOLOGIES INC COM 63009R109   10,033,967 1,258,967 SH   SOLE   1,227,848 0 31,119
NETFLIX INC COM 64110L106   6,136,158 20,809 SH   SOLE   20,809 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102   39,945,205 2,577,110 SH   SOLE   2,577,110 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105   3,333,144 583,738 SH   SOLE   556,937 0 26,801
ONEMAIN HLDGS INC COM 68268W103   83,708 2,513 SH   SOLE   2,513 0 0
ORACLE CORP COM 68389X105   609,699 7,459 SH   SOLE   7,459 0 0
PARDES BIOSCIENCES INC COM 69945Q105   2,054,984 1,215,967 SH   SOLE   1,215,967 0 0
PAYPAL HLDGS INC COM 70450Y103   1,486,361 20,870 SH   SOLE   20,870 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408   15,304,774 1,437,068 SH   SOLE   975,899 0 461,169
PIERIS PHARMACEUTICALS INC COM 720795103   1,269,630 1,220,798 SH   SOLE   1,220,798 0 0
PLANET FITNESS INC CL A 72703H101   15,867,404 201,363 SH   SOLE   201,363 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   29,237,010 265,791 SH   SOLE   224,248 0 41,543
PROTHENA CORP PLC SHS G72800108   2,500,857 41,508 SH   SOLE   41,508 0 0
QUANTERIX CORP COM 74766Q101   13,934,443 1,006,097 SH   SOLE   960,124 0 45,973
RALPH LAUREN CORP CL A 751212101   92,461 875 SH   SOLE   875 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104   20,896,714 2,710,339 SH   SOLE   2,665,045 0 45,294
ROBLOX CORP CL A 771049103   3,694,108 129,800 SH   SOLE   129,800 0 0
ROIVANT SCIENCES LTD SHS G76279101   4,439,356 555,614 SH   SOLE   555,614 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203   747,600 10,000 SH   SOLE   10,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,846,256 14,248 SH   SOLE   14,248 0 0
SCHLUMBERGER LTD COM STK 806857108   84,227,246 1,575,519 SH   SOLE   1,401,035 0 174,484
SCORPIO TANKERS INC SHS Y7542C130   48,792,027 907,421 SH   SOLE   767,394 0 140,027
SILVERCREST METALS INC COM 828363101   10,474,176 1,745,696 SH   SOLE   1,160,649 0 585,047
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   1,770,947 881,068 SH   SOLE   881,068 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102   5,029,812 216,336 SH   SOLE   216,336 0 0
SKYWORKS SOLUTIONS INC COM 83088M102   1,538,274 16,880 SH   SOLE   16,880 0 0
STANLEY BLACK & DECKER INC COM 854502101   77,824 1,036 SH   SOLE   1,036 0 0
SUNCOR ENERGY INC NEW COM 867224107   115,116,605 3,633,228 SH   SOLE   3,139,082 0 494,146
SUZANO S A SPON ADS 86959K105   39,225,482 4,245,182 SH   SOLE   4,245,182 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104   1,595,478 226,309 SH   SOLE   226,309 0 0
TORM PLC SHS CL A G89479102   2,603,831 89,264 SH   SOLE   89,264 0 0
TRIP COM GROUP LTD ADS 89677Q107   198,317,032 5,765,030 SH   SOLE   4,743,427 0 1,021,603
ULTA BEAUTY INC COM 90384S303   13,268,583 28,287 SH   SOLE   28,287 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100   99,750 708 SH   SOLE   708 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104   42,195 4,451 SH   SOLE   4,451 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   2,407,685 343,955 SH   SOLE   343,955 0 0
WESTERN DIGITAL CORP. COM 958102105   1,892,621 59,988 SH   SOLE   59,988 0 0
YUM CHINA HLDGS INC COM 98850P109   12,904,450 236,129 SH   SOLE   236,129 0 0
ZAI LAB LTD ADR 98887Q104   5,843,438 190,340 SH   SOLE   190,340 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105   454,936,991 16,931,038 SH   SOLE   14,510,916 0 2,420,122
ZYMEWORKS DEL INC COM 98985Y108   3,111,931 395,920 SH   SOLE   395,920 0 0