The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   59,009,771 2,656,901 SH   SOLE   2,656,901 0 0
89BIO INC COM 282559103   49,010,500 3,850,000 SH   SOLE   3,850,000 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   21,340,800 3,952,000 SH   SOLE   3,952,000 0 0
AGENUS INC COM NEW 00847G705   64,800,000 27,000,000 SH   SOLE   27,000,000 0 0
ALBIREO PHARMA INC COM 01345P106   36,823,440 1,704,000 SH   SOLE   1,704,000 0 0
ALLAKOS INC COM 01671P100   41,251,087 4,899,179 SH   SOLE   4,899,179 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   30,447,009 249,300 SH Call SOLE   249,300 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   85,491,000 700,000 SH   SOLE   700,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108   2,383,468 1,833,437 SH   SOLE   1,833,437 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   27,048,147 1,816,531 SH   SOLE   1,816,531 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   1,400,708 324,238 SH   SOLE   324,238 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   28,500,000 15,000,000 SH   SOLE   15,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   6,657,000 300,000 SH   SOLE   300,000 0 0
BEAM THERAPEUTICS INC COM 07373V105   45,620,759 1,166,473 SH   SOLE   1,166,473 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   83,443,732 2,819,045 SH   SOLE   2,819,045 0 0
BIOGEN INC COM 09062X103   83,076,000 300,000 SH   SOLE   300,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   19,642,402 189,800 SH   SOLE   189,800 0 0
CENTURY THERAPEUTICS INC COM 15673T100   3,569,685 695,845 SH   SOLE   695,845 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   78,600,000 3,000,000 SH   SOLE   3,000,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   19,193,571 1,048,829 SH   SOLE   1,048,829 0 0
DICE THERAPEUTICS INC COM 23345J104   54,105,262 1,734,143 SH   SOLE   1,734,143 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   24,769,399 2,327,951 SH   SOLE   2,327,951 0 0
DYNE THERAPEUTICS INC COM 26818M108   31,109,878 2,684,200 SH   SOLE   2,684,200 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   30,167,082 3,374,394 SH   SOLE   3,374,394 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   24,920,000 4,000,000 SH   SOLE   4,000,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109   5,595,459 768,607 SH   SOLE   768,607 0 0
GERON CORP COM 374163103   17,943,557 7,414,693 SH   SOLE   7,414,693 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   4,854,168 499,400 SH   SOLE   499,400 0 0
HERON THERAPEUTICS INC COM 427746102   16,242,440 6,496,976 SH   SOLE   6,496,976 0 0
HOOKIPA PHARMA INC COM 43906K100   1,004,699 1,240,369 SH   SOLE   1,240,369 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   56,900,000 500,000 SH   SOLE   500,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   56,900,000 500,000 SH Put SOLE   500,000 0 0
IMMUNOVANT INC COM 45258J102   172,352,500 9,710,000 SH   SOLE   9,710,000 0 0
INOZYME PHARMA INC COM 45790W108   3,412,500 3,250,000 SH   SOLE   3,250,000 0 0
INSMED INC COM PAR $.01 457669307   85,200,554 4,264,292 SH   SOLE   4,264,292 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   24,423,000 700,000 SH   SOLE   700,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100   45,542,046 1,205,773 SH   SOLE   1,205,773 0 0
IVERIC BIO INC COM 46583P102   168,670,528 7,878,119 SH   SOLE   7,878,119 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   139,165,728 873,553 SH   SOLE   873,553 0 0
JOUNCE THERAPEUTICS INC COM 481116101   4,728,215 4,259,653 SH   SOLE   4,259,653 0 0
MAGENTA THERAPEUTICS INC COM 55910K108   1,185,000 3,000,000 SH   SOLE   3,000,000 0 0
NKARTA INC COM 65487U108   8,111,658 1,354,200 SH   SOLE   1,354,200 0 0
NURIX THERAPEUTICS INC COM 67080M103   24,886,928 2,266,569 SH   SOLE   2,266,569 0 0
NUVATION BIO INC COM CL A 67080N101   15,784,681 8,221,188 SH   SOLE   8,221,188 0 0
PLIANT THERAPEUTICS INC COM 729139105   33,497,846 1,732,946 SH   SOLE   1,732,946 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   9,507,989 871,493 SH   SOLE   871,493 0 0
RAPT THERAPEUTICS INC COM 75382E109   25,837,812 1,304,940 SH   SOLE   1,304,940 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   478,674 12,600 SH Call SOLE   12,600 0 0
RELMADA THERAPEUTICS INC COM 75955J402   9,903,985 2,837,818 SH   SOLE   2,837,818 0 0
REPARE THERAPEUTICS INC COM 760273102   40,123,084 2,727,606 SH   SOLE   2,727,606 0 0
SAREPTA THERAPEUTICS INC COM 803607100   68,449,858 528,244 SH   SOLE   528,244 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   29,761,595 1,951,580 SH   SOLE   1,951,580 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   80,888,135 3,109,886 SH   SOLE   3,109,886 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   12,725,000 500,000 SH   SOLE   500,000 0 0
THIRD HARMONIC BIO INC COM 88427A107   1,915,960 445,572 SH   SOLE   445,572 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   96,359,460 4,582,000 SH   SOLE   4,582,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   83,287,154 3,187,415 SH   SOLE   3,187,415 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   26,302,175 2,104,174 SH   SOLE   2,104,174 0 0
VIKING THERAPEUTICS INC COM 92686J106   5,734,780 610,083 SH   SOLE   610,083 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   51,735,408 1,771,154 SH   SOLE   1,771,154 0 0