The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics Inc EQUITIES 00461U105   5,547,040 352,193 SH   SOLE   352,193 0 0
Acumen Pharmaceuticals Inc EQUITIES 00509G209   1,593,621 295,115 SH   SOLE   295,115 0 0
Aerovate Therapeutics Inc EQUITIES 008064107   1,081,346 36,906 SH   SOLE   36,906 0 0
Akero Therapeutics Inc LONG OPTION PUTS 00973Y108   8,220,000 150,000 SH Put SOLE   150,000 0 0
Akero Therapeutics Inc LONG OPTION CALLS 00973Y108   8,220,000 150,000 SH Call SOLE   150,000 0 0
Akero Therapeutics Inc EQUITIES 00973Y108   9,431,080 172,100 SH   SOLE   172,100 0 0
Allakos Inc EQUITIES 01671P100   4,047,502 480,701 SH   SOLE   480,701 0 0
Alnylam Pharmaceuticals Inc EQUITIES 02043Q107   8,947,998 37,652 SH   SOLE   37,652 0 0
Altimmune Inc EQUITIES 02155H200   831,482 50,546 SH   SOLE   50,546 0 0
Altimmune, Inc. LONG OPTION CALLS 02155H200   2,632,000 160,000 SH Call SOLE   160,000 0 0
Amryt Pharma PLC EQUITIES 03217L106   1,408,864 192,995 SH   SOLE   192,995 0 0
Anavex Life Science Corp LONG OPTION PUTS 032797300   9,331,302 1,007,700 SH Put SOLE   1,007,700 0 0
Anavex Life Science Corp LONG OPTION CALLS 032797300   950,076 102,600 SH Call SOLE   102,600 0 0
Ascendis Pharma A/S EQUITIES 04351P101   2,827,432 23,151 SH   SOLE   23,151 0 0
Astria Therapeutics Inc EQUITIES 04635X102   1,209,128 81,204 SH   SOLE   81,204 0 0
Avidity Biosciences Inc EQUITIES 05370A108   2,840,320 128,000 SH   SOLE   128,000 0 0
Axsome Therapeutics Inc EQUITIES 05464T104   771,300 10,000 SH   SOLE   10,000 0 0
Bellus Health Inc EQUITIES 07987C204   14,034,581 1,707,370 SH   SOLE   1,707,370 0 0
BioCryst Pharmaceuticals Inc EQUITIES 09058V103   3,124,546 272,173 SH   SOLE   272,173 0 0
Bioatla Inc EQUITIES 09077B104   4,511,719 546,875 SH   SOLE   546,875 0 0
Biogen Idec Inc EQUITIES 09062X103   6,085,317 21,975 SH   SOLE   21,975 0 0
Braze Inc EQUITIES 10576N102   272,800 10,000 SH   SOLE   10,000 0 0
CTI BioPharma Corp EQUITIES 12648L601   1,528,710 254,361 SH   SOLE   254,361 0 0
Celldex Therapeutics Inc EQUITIES 15117B202   2,437,934 54,699 SH   SOLE   54,699 0 0
Cerus Corp EQUITIES 157085101   5,964,151 1,634,014 SH   SOLE   1,634,014 0 0
Cincor Pharma Inc EQUITIES 17240Y109   4,859,245 395,382 SH   SOLE   395,382 0 0
Codexis Inc EQUITIES 192005106   674,474 144,737 SH   SOLE   144,737 0 0
Cogent Biosciences Inc EQUITIES 19240Q201   2,069,240 179,000 SH   SOLE   179,000 0 0
Compass Therapeutics Inc. EQUITIES 20454B104   1,349,584 268,307 SH   SOLE   268,307 0 0
Compugen Ltd EQUITIES M25722105   477,689 667,443 SH   SOLE   667,443 0 0
Crinetics Pharmaceuticals Inc EQUITIES 22663K107   2,795,270 152,747 SH   SOLE   152,747 0 0
Cue Biopharma Inc EQUITIES 22978P106   872,892 306,278 SH   SOLE   306,278 0 0
Cullinan Oncology Inc EQUITIES 230031106   2,420,339 229,416 SH   SOLE   229,416 0 0
Cvrx Inc EQUITIES 126638105   5,772,616 314,584 SH   SOLE   314,584 0 0
Cytokinetics Inc EQUITIES 23282W605   801,850 17,500 SH   SOLE   17,500 0 0
Design Therapeutics Inc EQUITIES 25056L103   585,077 57,025 SH   SOLE   57,025 0 0
Eliem Therapeutics Inc EQUITIES 28658R106   1,501,771 409,202 SH   SOLE   409,202 0 0
Eloxx Pharmaceuticals Inc EQUITIES 29014R202   48,914 26,876 SH   SOLE   26,876 0 0
Evogene Ltd EQUITIES M4119S104   105,253 150,361 SH   SOLE   150,361 0 0
Fresh Tracks Therapeutics Inc EQUITIES 10802T204   15,000 10,000 SH   SOLE   10,000 0 0
Gilead Sciences Inc EQUITIES 375558103   4,460,938 51,962 SH   SOLE   51,962 0 0
GlaxoSmithKline PLC EQUITIES 37733W204   4,785,295 136,178 SH   SOLE   136,178 0 0
Gossamer Bio Inc EQUITIES 38341P102   217,000 100,000 SH   SOLE   100,000 0 0
Horizon Therapeutics Plc EQUITIES G46188101   2,623,545 23,054 SH   SOLE   23,054 0 0
IVERIC bio Inc EQUITIES 46583P102   1,889,283 88,243 SH   SOLE   88,243 0 0
Immatics Nv EQUITIES N44445109   3,830,553 439,788 SH   SOLE   439,788 0 0
Immunic Inc EQUITIES 4525EP101   490,918 350,656 SH   SOLE   350,656 0 0
ImmunoGen Inc EQUITIES 45253H101   2,020,054 407,269 SH   SOLE   407,269 0 0
ImmunoGen, Inc. LONG OPTION CALLS 45253H101   1,150,720 232,000 SH Call SOLE   232,000 0 0
Immunovant Inc EQUITIES 45258J102   9,223,149 519,614 SH   SOLE   519,614 0 0
Insmed Inc EQUITIES 457669307   2,486,811 124,465 SH   SOLE   124,465 0 0
Intellia Therapeutics Inc EQUITIES 45826J105   1,143,345 32,770 SH   SOLE   32,770 0 0
Intra-Cellular Therapies Inc EQUITIES 46116X101   7,428,169 140,366 SH   SOLE   140,366 0 0
Krystal Biotech Inc EQUITIES 501147102   4,637,143 58,535 SH   SOLE   58,535 0 0
LAVA Therapeutics NV EQUITIES N51517105   1,532,167 437,762 SH   SOLE   437,762 0 0
MacroGenics Inc EQUITIES 556099109   4,109,707 612,475 SH   SOLE   612,475 0 0
Madrigal Parmaceuticals, Inc. LONG OPTION PUTS 558868105   8,707,500 30,000 SH Put SOLE   30,000 0 0
Madrigal Pharmaceuticals Inc EQUITIES 558868105   14,482,895 49,898 SH   SOLE   49,898 0 0
Medicus Sciences Acquisition Corp WARRANTS G5960S124   4,499 49,990 SH   SOLE   49,990 0 0
Meiragtx Holdings Plc EQUITIES G59665102   369,501 56,672 SH   SOLE   56,672 0 0
Mersana Therapeutics Inc EQUITIES 59045L106   6,681,467 1,140,182 SH   SOLE   1,140,182 0 0
Merus NV EQUITIES N5749R100   4,249,671 274,704 SH   SOLE   274,704 0 0
Morphic Holding Inc EQUITIES 61775R105   8,948,811 334,535 SH   SOLE   334,535 0 0
Nuvalent Inc EQUITIES 670703107   9,022,238 302,963 SH   SOLE   302,963 0 0
Oric Pharmaceuticals Inc EQUITIES 68622P109   7,281,783 1,236,296 SH   SOLE   1,236,296 0 0
Pharvaris NV EQUITIES N69605108   1,125,000 100,000 SH   SOLE   100,000 0 0
Phreesia Inc EQUITIES 71944F106   2,763,220 85,390 SH   SOLE   85,390 0 0
Pliant Therapeutics Inc EQUITIES 729139105   4,204,333 217,503 SH   SOLE   217,503 0 0
Point Biopharma Global Inc EQUITIES 730541109   2,921,919 400,812 SH   SOLE   400,812 0 0
Poseida Therapeutics Inc EQUITIES 73730P108   11,819,000 2,230,000 SH   SOLE   2,230,000 0 0
Praxis Precision Medicines Inc EQUITIES 74006W108   234,213 98,409 SH   SOLE   98,409 0 0
Prometheus Bioscience, Inc. LONG OPTION PUTS 74349U108   18,964,000 172,400 SH Put SOLE   172,400 0 0
Prometheus Biosciences Inc EQUITIES 74349U108   5,500,000 50,000 SH   SOLE   50,000 0 0
Prothena Corporation PLC EQUITIES G72800108   4,320,287 71,706 SH   SOLE   71,706 0 0
Schrodinger Inc EQUITIES 80810D103   2,018,520 108,000 SH   SOLE   108,000 0 0
Seagen Inc EQUITIES 81181C104   1,415,666 11,016 SH   SOLE   11,016 0 0
Seres Therapeutics Inc EQUITIES 81750R102   2,096,763 374,422 SH   SOLE   374,422 0 0
Stereotaxis Inc EQUITIES 85916J409   734,695 354,925 SH   SOLE   354,925 0 0
Terns Pharmaceuticals Inc EQUITIES 880881107   7,126,000 700,000 SH   SOLE   700,000 0 0
Trevi Therapeutics Inc EQUITIES 89532M101   1,481,528 767,631 SH   SOLE   767,631 0 0
Uniqure NV EQUITIES N90064101   226,700 10,000 SH   SOLE   10,000 0 0
United Therapeutics Corp EQUITIES 91307C102   4,462,788 16,048 SH   SOLE   16,048 0 0
Vaxcyte Inc EQUITIES 92243G108   3,986,323 83,135 SH   SOLE   83,135 0 0
Veracyte Inc EQUITIES 92337F107   4,746,000 200,000 SH   SOLE   200,000 0 0
Vertex Pharmaceuticals Inc EQUITIES 92532F100   3,287,472 11,384 SH   SOLE   11,384 0 0
Veru Inc. LONG OPTION PUTS 92536C103   924,000 175,000 SH Put SOLE   175,000 0 0
Viewray Inc EQUITIES 92672L107   10,776,013 2,405,360 SH   SOLE   2,405,360 0 0
Viridian Therapeutics Inc EQUITIES 92790C104   87,630 3,000 SH   SOLE   3,000 0 0
WAVE Life Sciences Ltd EQUITIES Y95308105   350,000 50,000 SH   SOLE   50,000 0 0
Xenon Pharmaceuticals Inc EQUITIES 98420N105   10,001,617 253,655 SH   SOLE   253,655 0 0