The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   89,004,643 4,007,413 SH   DFND 1 0 4,007,413 0
AADI BIOSCIENCE INC COM 00032Q104   7,214,424 562,309 SH   DFND 1 0 562,309 0
AC IMMUNE SA SHS H00263105   15,153,893 7,428,379 SH   DFND 1 0 7,428,379 0
ACLARIS THERAPEUTICS INC COM 00461U105   51,605,552 3,276,543 SH   DFND 1 0 3,276,543 0
AILERON THERAPEUTICS INC COM NEW 00887A204   561,299 236,835 SH   DFND 1 0 236,835 0
ALLAKOS INC COM 01671P100   42,158,275 5,006,921 SH   DFND 1 0 5,006,921 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   8,349,159 1,135,940 SH   DFND 1 0 1,135,940 0
AN2 THERAPEUTICS INC COM 037326105   14,904,567 1,563,963 SH   DFND 1 0 1,563,963 0
ANGION BIOMEDICA CORP COM 03476J107   869,465 1,071,297 SH   DFND 1 0 1,071,297 0
ANNEXON INC COM 03589W102   19,546,188 3,780,694 SH   DFND 1 0 3,780,694 0
ARAVIVE INC COM 03890D108   6,315,162 4,784,214 SH   DFND 1 0 4,784,214 0
ARCUS BIOSCIENCES INC COM 03969F109   47,636,794 2,303,520 SH   DFND 1 0 2,303,520 0
AXSOME THERAPEUTICS INC COM 05464T104   135,363,150 1,755,000 SH   DFND 1 0 1,755,000 0
BIONOMICS LIMITED ADS 09063M205   373,276 80,971 SH   DFND 1 0 80,971 0
CALITHERA BIOSCIENCES INC COM NEW 13089P507   1,515,059 464,742 SH   DFND 1 0 464,742 0
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106   13,147,500 750,000 SH   DFND 1 0 750,000 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   21,372,470 6,894,345 SH   DFND 1 0 6,894,345 0
CIDARA THERAPEUTICS INC COM 171757107   5,189,070 6,861,127 SH   DFND 1 0 6,861,127 0
COGENT BIOSCIENCES INC COM 19240Q201   11,384,565 984,824 SH   DFND 1 0 984,824 0
CONCERT PHARMACEUTICALS INC COM 206022105   21,193,360 3,629,000 SH   DFND 1 0 3,629,000 0
CORVUS PHARMACEUTICALS INC COM 221015100   1,165,305 1,370,947 SH   DFND 1 0 1,370,947 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   50,080,018 2,736,613 SH   DFND 1 0 2,736,613 0
CTI BIOPHARMA CORP COM 12648L601   52,966,256 8,813,021 SH   DFND 1 0 8,813,021 0
CULLINAN ONCOLOGY INC COM 230031106   79,220,572 7,509,059 SH   DFND 1 0 7,509,059 0
CYTOMX THERAPEUTICS INC COM 23284F105   10,553,282 6,595,801 SH   DFND 1 0 6,595,801 0
ELEDON PHARMACEUTICALS INC COM 28617K101   5,397,967 2,326,710 SH   DFND 1 0 2,326,710 0
ELEVATION ONCOLOGY INC COM 28623U101   2,191,272 2,312,200 SH   DFND 1 0 2,312,200 0
ESSA PHARMA INC COM NEW 29668H708   22,046,545 8,748,629 SH   DFND 1 0 8,748,629 0
GALAPAGOS NV SPON ADR 36315X101   4,438,000 100,000 SH   DFND 1 0 100,000 0
GALMED PHARMACEUTICALS LTD SHS M47238106   869,835 1,739,670 SH   DFND 1 0 1,739,670 0
GENERATION BIO CO COM 37148K100   404,397 102,900 SH   DFND 1 0 102,900 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   89,690,778 9,275,158 SH   DFND 1 0 9,275,158 0
GLYCOMIMETICS INC COM 38000Q102   28,919,114 9,544,262 SH   DFND 1 0 9,544,262 0
HILLEVAX INC COM 43157M102   4,158,727 248,579 SH   DFND 1 0 248,579 0
IDEAYA BIOSCIENCES INC COM 45166A102   40,066,467 2,205,089 SH   DFND 1 0 2,205,089 0
IKENA ONCOLOGY INC COM 45175G108   6,658,169 2,503,071 SH   DFND 1 0 2,503,071 0
IMMUNIC INC COM 4525EP101   1,609,195 1,149,425 SH   DFND 1 0 1,149,425 0
IMMUNOVANT INC COM 45258J102   45,457,750 2,561,000 SH   DFND 1 0 2,561,000 0
INFINITY PHARMACEUTICALS INC COM 45665G303   3,526,273 6,353,645 SH   DFND 1 0 6,353,645 0
INVENTIVA SA ADS 46124U107   3,039,157 686,040 SH   DFND 1 0 686,040 0
IONIS PHARMACEUTICALS INC COM 462222100   42,370,726 1,121,809 SH   DFND 1 0 1,121,809 0
ITEOS THERAPEUTICS INC COM 46565G104   35,365,608 1,810,835 SH   DFND 1 0 1,810,835 0
JANUX THERAPEUTICS INC COM 47103J105   19,364,299 1,470,334 SH   DFND 1 0 1,470,334 0
KURA ONCOLOGY INC COM 50127T109   47,170,199 3,800,983 SH   DFND 1 0 3,800,983 0
KYMERA THERAPEUTICS INC COM 501575104   117,127,396 4,692,604 SH   DFND 1 0 4,692,604 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   30,844,932 16,149,179 SH   DFND 1 0 16,149,179 0
MERUS N V COM N5749R100   46,076,157 2,978,420 SH   DFND 1 0 2,978,420 0
MOLECULAR PARTNERS AG ADS 60853G106   2,872,072 443,221 SH   DFND 1 0 443,221 0
MOLECULAR TEMPLATES INC COM 608550109   1,638,873 4,996,565 SH   DFND 1 0 4,996,565 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   228,388,482 21,751,284 SH   DFND 1 0 21,751,284 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109   16,010,893 1,521,948 SH   DFND 1 0 1,521,948 0
NLS PHARMACEUTICS LTD SHS H57830103   7,413,793 5,747,126 SH   DFND 1 0 5,747,126 0
OLEMA PHARMACEUTICALS INC COM 68062P106   18,648,182 7,611,503 SH   DFND 1 0 7,611,503 0
OVID THERAPEUTICS INC COM 690469101   12,742,955 6,851,051 SH   DFND 1 0 6,851,051 0
PIERIS PHARMACEUTICALS INC COM 720795103   5,283,533 5,080,320 SH   DFND 1 0 5,080,320 0
POINT BIOPHARMA GLOBAL INC COM 730541109   66,905,783 9,177,748 SH   DFND 1 0 9,177,748 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   3,938,060 2,938,851 SH   DFND 1 0 2,938,851 0
RAIN ONCOLOGY INC COM 75082Q105   28,213,832 3,526,729 SH   DFND 1 0 3,526,729 0
RELAY THERAPEUTICS INC COM 75943R102   57,907,754 3,876,021 SH   DFND 1 0 3,876,021 0
REPARE THERAPEUTICS INC COM 760273102   121,975,143 8,291,988 SH   DFND 1 0 8,291,988 0
REPLIMUNE GROUP INC COM 76029N106   41,415,509 1,522,629 SH   DFND 1 0 1,522,629 0
REVOLUTION MEDICINES INC COM 76155X100   77,548,106 3,255,588 SH   DFND 1 0 3,255,588 0
REZOLUTE INC COM NEW 76200L309   394,987 190,815 SH   DFND 1 0 190,815 0
SELECTA BIOSCIENCES INC COM 816212104   1,572,676 1,391,749 SH   DFND 1 0 1,391,749 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   23,003,344 1,508,416 SH   DFND 1 0 1,508,416 0
SUTRO BIOPHARMA INC COM 869367102   27,051,404 3,347,946 SH   DFND 1 0 3,347,946 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   36,932,964 1,451,197 SH   DFND 1 0 1,451,197 0
THIRD HARMONIC BIO INC COM 88427A107   18,773,512 4,365,933 SH   DFND 1 0 4,365,933 0
TYRA BIOSCIENCES INC COM 90240B106   18,789,685 2,472,327 SH   DFND 1 0 2,472,327 0
VERASTEM INC COM 92337C104   7,656,619 19,022,656 SH   DFND 1 0 19,022,656 0
VERVE THERAPEUTICS INC COM 92539P101   12,577,500 650,000 SH   DFND 1 0 650,000 0
VIGIL NEUROSCIENCE INC COM 92673K108   22,670,413 1,813,633 SH   DFND 1 0 1,813,633 0
VIRACTA THERAPEUTICS INC COM 92765F108   5,277,407 3,614,662 SH   DFND 1 0 3,614,662 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   36,190,431 1,238,974 SH   DFND 1 0 1,238,974 0
X4 PHARMACEUTICALS INC COM 98420X103   1,338,216 1,347,650 SH   DFND 1 0 1,347,650 0
XENON PHARMACEUTICALS INC COM 98420N105   50,125,111 1,271,243 SH   DFND 1 0 1,271,243 0
XOMA CORP DEL COM NEW 98419J206   66,451,490 3,611,494 SH   DFND 1 0 3,611,494 0
ZYMEWORKS DEL INC COM 98985Y108   46,138,200 5,870,000 SH   DFND 1 0 5,870,000 0