The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   5,779,419 454,000 SH   SOLE   454,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   5,174,001 325,000 SH   SOLE   325,000 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   1,376,703 254,945 SH   SOLE   254,945 0 0
AEROVATE THERAPEUTICS INC COM 008064107   3,748,085 127,921 SH   SOLE   127,921 0 0
ALTIMMUNE INC COM NEW 02155H200   4,497,956 273,432 SH   SOLE   273,432 0 0
ALTIMMUNE INC COM NEW 02155H200   9,498,230 577,400 SH Call SOLE   577,400 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103   374,888 156,203 SH   SOLE   156,203 0 0
ARCUS BIOSCIENCES INC COM 03969F109   2,853,572 137,987 SH   SOLE   137,987 0 0
ARCUS BIOSCIENCES INC COM 03969F109   5,854,508 283,100 SH Put SOLE   283,100 0 0
ARDELYX INC COM 039697107   3,929,651 1,378,825 SH   SOLE   1,378,825 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302   1,311,622 46,462 SH   SOLE   46,462 0 0
ARK ETF TR INNOVATION ETF 00214Q104   141,174 4,519 SH   SOLE   4,519 0 0
ARVINAS INC COM 04335A105   3,421,000 100,000 SH Call SOLE   100,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101   151,446 820,455 SH   SOLE   820,455 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   2,547,679 171,100 SH Call SOLE   171,100 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   10,053,370 675,176 SH   SOLE   675,176 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   494,166 260,087 SH   SOLE   260,087 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404   322,633 448,101 SH   SOLE   448,101 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   7,277,445 885,334 SH   SOLE   885,334 0 0
BIOGEN INC COM 09062X103   266,398 962 SH   SOLE   962 0 0
BIOGEN INC COM 09062X103   498,456 1,800 SH Call SOLE   1,800 0 0
BIOHAVEN LTD COM G1110E107   11,624,500 837,500 SH   SOLE   837,500 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105   5,370,000 250,000 SH   SOLE   250,000 0 0
BLUEBIRD BIO INC COM 09609G100   5,623,385 812,628 SH   SOLE   812,628 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201   311,494 189,935 SH   SOLE   189,935 0 0
CABALETTA BIO INC COM 12674W109   280,145 30,286 SH   SOLE   30,286 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   11,921,406 267,476 SH   SOLE   267,476 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   1,002,855 313,392 SH   SOLE   313,392 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   0 283,464 SH   SOLE   283,464 0 0
COGENT BIOSCIENCES INC COM 19240Q201   725,576 62,766 SH   SOLE   62,766 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101   190,482 219,501 SH   SOLE   219,501 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103   43,888 397,168 SH   SOLE   397,168 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   6,017,081 367,119 SH   SOLE   367,119 0 0
DESIGN THERAPEUTICS INC COM 25056L103   8,208 800 SH Call SOLE   800 0 0
DESIGN THERAPEUTICS INC COM 25056L103   497,610 48,500 SH Put SOLE   48,500 0 0
DESIGN THERAPEUTICS INC COM 25056L103   118,689 11,568 SH   SOLE   11,568 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   514,645 221,830 SH   SOLE   221,830 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108   1,185 3,019 SH   SOLE   3,019 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   8,079,687 1,296,900 SH Call SOLE   1,296,900 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   11,781,846 1,891,147 SH   SOLE   1,891,147 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101   114,026 237,553 SH   SOLE   237,553 0 0
GERON CORP COM 374163103   363,000 150,000 SH Put SOLE   150,000 0 0
GERON CORP COM 374163103   1,573,000 650,000 SH Call SOLE   650,000 0 0
GOSSAMER BIO INC COM 38341P102   13,237 6,100 SH   SOLE   6,100 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   10,153,123 89,219 SH   SOLE   89,219 0 0
IMMATICS N.V SHS N44445109   427,060 49,031 SH   SOLE   49,031 0 0
IMMUNIC INC COM 4525EP101   910,000 650,000 SH   SOLE   650,000 0 0
IMMUNOVANT INC COM 45258J102   17,158,925 966,700 SH   SOLE   966,700 0 0
IMMUNOVANT INC COM 45258J102   465,050 26,200 SH Call SOLE   26,200 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108   1,053,924 85,200 SH   SOLE   85,200 0 0
IVERIC BIO INC COM 46583P102   8,072,019 377,021 SH   SOLE   377,021 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   4,435,102 629,986 SH   SOLE   629,986 0 0
KRYSTAL BIOTECH INC COM 501147102   13,142,598 165,900 SH Put SOLE   165,900 0 0
LYRA THERAPEUTICS INC COM 55234L105   1,079,171 343,685 SH   SOLE   343,685 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   21,770 75 SH   SOLE   75 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   87,075,000 300,000 SH Put SOLE   300,000 0 0
MERUS N V COM N5749R100   2,413,320 156,000 SH   SOLE   156,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   1,823,248 460,416 SH   SOLE   460,416 0 0
MIRATI THERAPEUTICS INC COM 60468T105   4,898,010 108,100 SH   SOLE   108,100 0 0
OCULAR THERAPEUTIX INC COM 67576A100   562,000 200,000 SH   SOLE   200,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   1,017,429 139,565 SH   SOLE   139,565 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108   357,000 150,000 SH   SOLE   150,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   11,000,000 100,000 SH Call SOLE   100,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   31,781,860 288,926 SH   SOLE   288,926 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109   1,563,713 422,625 SH   SOLE   422,625 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107   505,619 188,664 SH   SOLE   188,664 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   7,643,588 201,200 SH Put SOLE   201,200 0 0
RELMADA THERAPEUTICS INC COM 75955J402   228,563 65,491 SH   SOLE   65,491 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   363,059 155,819 SH   SOLE   155,819 0 0
SAGE THERAPEUTICS INC COM 78667J108   2,586,083 67,805 SH   SOLE   67,805 0 0
SAREPTA THERAPEUTICS INC COM 803607100   3,670,224 28,324 SH   SOLE   28,324 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107   122,453 136,059 SH   SOLE   136,059 0 0
SEAGEN INC COM 81181C104   3,212,750 25,000 SH   SOLE   25,000 0 0
SPDR SER TR S&P BIOTECH 78464A870   8,300,000 100,000 SH Call SOLE   100,000 0 0
SPDR SER TR S&P BIOTECH 78464A870   8,300,000 100,000 SH Put SOLE   100,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108   65,217 176,980 SH   SOLE   176,980 0 0
SYNLOGIC INC COM 87166L100   233,135 306,757 SH   SOLE   306,757 0 0
TERNS PHARMACEUTICALS INC COM 880881107   7,505,908 737,319 SH   SOLE   737,319 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209   4,120,639 2,765,530 SH   SOLE   2,765,530 0 0
TRICIDA INC COM 89610F101   22,277 145,700 SH Call SOLE   145,700 0 0
VAXCYTE INC COM 92243G108   11,987,501 250,000 SH   SOLE   250,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   5,226,000 200,000 SH Call SOLE   200,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   6,666,573 255,131 SH   SOLE   255,131 0 0
VIKING THERAPEUTICS INC COM 92686J106   1,909,666 203,156 SH   SOLE   203,156 0 0
X4 PHARMACEUTICALS INC COM 98420X103   346,689 349,133 SH   SOLE   349,133 0 0
XENON PHARMACEUTICALS INC COM 98420N105   6,327,963 160,486 SH   SOLE   160,486 0 0