Overview Financials News + Filings Key Docs Charts Ownership Insiders
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| In millions, except per share items | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 | Dec-31-11 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenue | | | | | | | | |
| Operating expenses | | | | | | | | |
| Research and development | 50.1 | 63.6 | 56.8 | 56.6 | 53.5 | 46.7 | 39.0 | 35.4 |
| General and administrative | 23.9 | 26.0 | 23.0 | 24.7 | 15.9 | 12.7 | 10.9 | 9.2 |
| Restructuring charges (Note 4) | 1.9 | | | | | | | |
| Total operating expenses | 75.9 | 89.6 | 79.9 | 81.2 | 69.4 | 59.5 | 49.9 | 44.6 |
| Loss from operations | -75.9 | -89.6 | -64.9 | -15.1 | -69.4 | -59.5 | -47.3 | -44.3 |
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| Other income (expense) | | | | | | | | |
| Interest income | 5.7 | 4.4 | 3.2 | 1.2 | 0.5 | 0.6 | 0.2 | |
| Interest expense | 0.0 | -0.1 | -0.1 | -0.1 | 0.0 | -0.1 | -0.1 | |
| Net loss | -70.3 | -85.2 | -61.7 | -5.0 | -69.0 | -58.9 | -47.1 | -44.2 |
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| Basic and diluted net loss per share (Note 5) | ($0.51) | ($0.62) | ($0.45) | ($0.04) | ($0.70) | ($0.63) | ($0.64) | ($0.69) |
| Total comprehensive loss (Note 9) | -70.1 | -85.8 | -61.5 | -5.1 | -69.0 | -59.0 | -47.1 | -44.2 |
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| Weighted average number of shares used in computing basic and diluted net loss per share | 138.4 | 137.2 | 136.7 | 125.6 | 98.4 | 94.0 | 74.0 | 64.2 |
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