| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/06/2023 | Wirick Angela L | CFO | Payment of Exercise | Common Stock | 5.2k | $57.23 | $297.1k | | 08/06/2023 |
| 08/04/2023 | CARREL MICHAEL H | President, CEO, & Director | Gift | Common Stock | 1.2k | $0.00 | $0 | | 08/04/2023 |
| 07/26/2023 | Dahlquist Karl S. | Chief Legal Officer | Sale | Common Stock | 3.4k | $57.09 | $195.1k | | 07/26/2023 |
| 06/30/2023 | CARREL MICHAEL H | President, CEO, & Director | Grant | Common Stock | 557 | $38.11 | $21.2k | | 06/30/2023 |
| 06/30/2023 | Privitera Salvatore | Chief Technical Officer | Grant | Common Stock | 557 | $38.11 | $21.2k | | 06/30/2023 |
| 06/30/2023 | Seith Douglas J | COO | Grant | Common Stock | 557 | $38.11 | $21.2k | | 06/30/2023 |
| 06/30/2023 | Doraiswamy Vinayak | Chief Scientific Officer | Grant | Common Stock | 557 | $38.11 | $21.2k | | 06/30/2023 |
| 06/30/2023 | Noznesky Justin J | Chief Mktg & Strategy Officer | Grant | Common Stock | 547 | $38.11 | $20.8k | | 06/30/2023 |
| 06/30/2023 | Dahlquist Karl S. | Chief Legal Officer | Grant | Common Stock | 557 | $38.11 | $21.2k | | 06/30/2023 |
| 06/30/2023 | Yount Deborah Lee | Chief Human Resources Officer | Grant | Common Stock | 450 | $38.11 | $17.1k | | 06/30/2023 |
| 06/08/2023 | Prange Karen | Director | Sale | Common Stock | 713 | $47.89 | $34.1k | | 06/08/2023 |
| 06/06/2023 | Dahlquist Karl S. | Chief Legal Officer | Sale | Common Stock | 1.4k | $47.03 | $66.9k | | 06/06/2023 |
| 05/31/2023 | CARREL MICHAEL H | President, CEO, & Director | Gift | Common Stock | 1000 | $0.00 | $0 | | 05/31/2023 |
| 05/25/2023 | JOHNSON B KRISTINE | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | Prange Karen | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | WEHRWEIN SVEN | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | Telman Deborah H | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | WHITE ROBERT S. | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | GROVES REGINA E | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 05/25/2023 | Yuen Maggie | Director | Grant | Common Stock | 3.2k | $0.00 | $0 | | 05/25/2023 |
| 03/13/2023 | Collar Mark A | Director | Exercise | Non-qualified Stock Option (right to buy) | 10k | $9.30 | $93k | | 03/13/2023 |
| 02/27/2023 | WHITE ROBERT S. | Director | Exercise | Non-qualified Stock Option (right to buy) | 20k | $8.48 | $169.6k | | 02/27/2023 |
| 12/30/2022 | Noznesky Justin J | Chief Mktg & Strategy Officer | Grant | Common Stock | 585 | $34.86 | $20.4k | | 12/30/2022 |
| 12/30/2022 | Yount Deborah Lee | Chief Human Resources Officer | Grant | Common Stock | 294 | $34.86 | $10.2k | | 12/30/2022 |
| 12/30/2022 | Seith Douglas J | COO | Grant | Common Stock | 609 | $34.86 | $21.2k | | 12/30/2022 |
| 11/17/2022 | CARREL MICHAEL H | President, CEO, & Director | Gift | Common Stock | 6k | $0.00 | $0 | | 11/17/2022 |
| 09/15/2022 | Doraiswamy Vinayak | Chief Scientific Officer | Sale | Common Stock | 5k | $45.99 | $229.2k | | 09/15/2022 |
| 08/31/2022 | WHITE ROBERT S. | Director | Exercise | Non-qualified Stock Option (right to buy) | 15k | $8.48 | $127.2k | | 08/31/2022 |
| 08/06/2022 | Wirick Angela L | CFO | Payment of Exercise | Common Stock | 5.2k | $50.94 | $264.4k | | 08/06/2022 |
| 06/30/2022 | Doraiswamy Vinayak | Chief Scientific Officer | Grant | Common Stock | 350 | $34.73 | $12.2k | | 06/30/2022 |
| 06/30/2022 | Dahlquist Karl S. | Chief Legal Officer | Grant | Common Stock | 350 | $34.73 | $12.2k | | 06/30/2022 |
| 06/30/2022 | CARREL MICHAEL H | President, CEO, & Director | Grant | Common Stock | 350 | $34.73 | $12.2k | | 06/30/2022 |
| 06/30/2022 | Privitera Salvatore | Chief Technical Officer | Grant | Common Stock | 350 | $34.73 | $12.2k | | 06/30/2022 |
| 06/01/2022 | Yount Deborah Lee | Chief Human Resources Officer | Grant | Common Stock | 16.9k | $0.00 | $0 | | 06/01/2022 |
| 05/25/2022 | Collar Mark A | Director | Grant | Common Stock | 3.6k | $0.00 | $0 | | 05/25/2022 |
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