| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/03/2023 | Radovich Peter | COO | Sale | Common Stock | 1.4k | $25.65 | $36.5k | | 07/03/2023 |
| 07/03/2023 | Peetz Christopher | President and CEO | Sale | Common Stock | 5.5k | $25.65 | $141k | | 07/03/2023 |
| 07/03/2023 | Vig Pamela | Head of Research & Development | Sale | Common Stock | 1.4k | $25.65 | $36.5k | | 07/03/2023 |
| 07/03/2023 | Longpre Lara | Chief Development Officer | Sale | Common Stock | 1k | $25.65 | $25.7k | | 07/03/2023 |
| 07/03/2023 | Howe Jolanda | SVP, Global Controller | Sale | Common Stock | 915 | $25.65 | $23.5k | | 06/30/2023 |
| 07/01/2023 | Howe Jolanda | SVP, Global Controller | Exercise | Restricted Stock Units | 1k | $0.00 | $0 | | 06/30/2023 |
| 06/30/2023 | Howe Jolanda | SVP, Global Controller | Exercise | Performance Restricted Stock Units | 1.6k | $0.00 | $0 | | 06/30/2023 |
| 06/08/2023 | GREY MICHAEL G | Director | Sale | Common Stock | 14.6k | $29.00 | $423.6k | | 06/08/2023 |
| 06/08/2023 | GREY MICHAEL G | Director | Exercise | Stock Option (right to buy) | 14.6k | $2.94 | $42.9k | | 06/08/2023 |
| 05/10/2023 | Radovich Peter | COO | Grant | Common Stock | 968 | $16.92 | $16.4k | | 05/10/2023 |
| 05/10/2023 | Vig Pamela | Head of Research & Development | Grant | Common Stock | 684 | $16.92 | $11.6k | | 05/10/2023 |
| 05/10/2023 | Peetz Christopher | President and CEO | Grant | Common Stock | 1.3k | $16.92 | $21.3k | | 05/10/2023 |
| 05/10/2023 | Longpre Lara | Chief Development Officer | Grant | Common Stock | 684 | $16.92 | $11.6k | | 05/10/2023 |
| 05/03/2023 | GREY MICHAEL G | Director | Sale | Common Stock | 14.6k | $28.00 | $409k | | 05/03/2023 |
| 05/03/2023 | GREY MICHAEL G | Director | Exercise | Stock Option (right to buy) | 14.6k | $2.94 | $42.9k | | 05/03/2023 |
| 12/19/2022 | Cardon Lon | Director | Grant | Stock Option (right to buy) | 34k | $18.00 | $612k | | 12/19/2022 |
| 11/15/2022 | O'Donnell Niall | Director | Sale | Common Stock | 93.8k | $19.69 | $1.8M | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 11/14/2022 | O'Donnell Niall | Director | Sale | Common Stock | 32.1k | $19.60 | $629.4k | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 11/11/2022 | O'Donnell Niall | Director | Sale | Common Stock | 174.1k | $19.99 | $3.5M | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 11/10/2022 | Longpre Lara | Chief Development Officer | Grant | Common Stock | 82 | $17.05 | $1.4k | | 11/10/2022 |
| 11/10/2022 | Radovich Peter | COO | Grant | Common Stock | 292 | $17.05 | $5k | | 11/10/2022 |
| 11/10/2022 | Peetz Christopher | President and CEO | Grant | Common Stock | 49 | $17.05 | $835.5 | | 11/10/2022 |
| 11/10/2022 | Clements Ian | CFO | Grant | Common Stock | 325 | $17.05 | $5.5k | | 11/10/2022 |
| 11/10/2022 | Vig Pamela | Head of Research & Development | Grant | Common Stock | 660 | $17.05 | $11.3k | | 11/10/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 13.1k | $25.29 | $332.1k | Through Deerfield Private Design Fund IV, L.P. | 06/06/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 11.9k | $25.29 | $300.1k | Through Deerfield Healthcare Innovations Fund, L.P. | 06/06/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 171 | $25.08 | $4.3k | Through Deerfield Private Design Fund IV, L.P. | 06/06/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 155 | $25.08 | $3.9k | Through Deerfield Healthcare Innovations Fund, L.P. | 06/06/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.9k | $24.47 | $169.1k | Through Deerfield Private Design Fund IV, L.P. | 06/06/2022 |
| 06/06/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.2k | $24.47 | $152.8k | Through Deerfield Healthcare Innovations Fund, L.P. | 06/06/2022 |
| 06/02/2022 | Brege Laura | Director | Grant | Stock Option (right to buy) | 17k | $23.51 | $399.7k | | 06/02/2022 |
| 06/02/2022 | GREY MICHAEL G | Director | Grant | Stock Option (right to buy) | 17k | $23.51 | $399.7k | | 06/02/2022 |
| 06/02/2022 | Heron Patrick J | 10% Owner | Grant | Stock Option (right to buy) | 17k | $23.51 | $399.7k | | 06/02/2022 |
| 06/02/2022 | Fischer Laurent | Director | Grant | Stock Option (right to buy) | 17k | $23.51 | $399.7k | | 06/02/2022 |
| 06/02/2022 | Ramasastry Saira | Director | Grant | Stock Option (right to buy) | 34k | $23.51 | $799.3k | | 06/02/2022 |
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