| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 122 | $193.18 | $23.6k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 562 | $193.93 | $109k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 625 | $194.94 | $121.8k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 64 | $195.65 | $12.5k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 103 | $197.08 | $20.3k | | 04/26/2023 |
| 04/26/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.3k | $0.00 | $0 | | 04/26/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Restricted Stock Units | 5k | $0.00 | $0 | | 02/27/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 10.4k | $190.01 | $2M | | 02/27/2023 |
| 02/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 128 | $227.68 | $29.1k | | 02/01/2023 |
| 02/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 185 | $230.20 | $42.6k | | 02/01/2023 |
| 02/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 865 | $231.35 | $200.1k | | 02/01/2023 |
| 02/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.3k | $232.53 | $300.7k | | 02/01/2023 |
| 02/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 953 | $233.31 | $222.3k | | 02/01/2023 |
| 02/02/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 73 | $223.97 | $16.3k | | 02/01/2023 |
| 02/02/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 963 | $225.80 | $217.4k | | 02/01/2023 |
| 02/02/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 561 | $226.62 | $127.1k | | 02/01/2023 |
| 02/02/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 4 | $227.38 | $909.5 | | 02/01/2023 |
| 02/01/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Restricted Stock Units | 5k | $0.00 | $0 | | 02/01/2023 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 149 | $215.03 | $32k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 398 | $216.21 | $86.1k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 440 | $217.61 | $95.7k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 541 | $218.71 | $118.3k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 99 | $219.53 | $21.7k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 105 | $220.95 | $23.2k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 5 | $224.00 | $1.1k | | 08/03/2022 |
| 08/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 104 | $225.15 | $23.4k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 1.6k | $189.76 | $307k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 170 | $210.50 | $35.8k | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.6k | $0.00 | $0 | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.8k | $210.00 | $368.3k | | 08/03/2022 |
| 07/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.8k | $150.00 | $263.1k | | 07/05/2022 |
| 02/23/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 18.4k | $147.47 | $2.7M | | 02/23/2022 |