| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 878 | $58.15 | $51.1k | | 08/16/2023 |
| 08/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 748 | $58.93 | $44.1k | | 08/16/2023 |
| 08/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 374 | $59.74 | $22.3k | | 08/16/2023 |
| 08/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 2k | $24.90 | $49.8k | | 08/16/2023 |
| 07/12/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 1.9k | $67.48 | $128.8k | | 07/12/2023 |
| 07/12/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 92 | $68.20 | $6.3k | | 07/12/2023 |
| 07/12/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 2k | $24.90 | $49.8k | | 07/12/2023 |
| 06/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 7.3k | $74.00 | $542.5k | | 06/16/2023 |
| 06/16/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 7.3k | $24.90 | $182.5k | | 06/16/2023 |
| 03/15/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 6k | $48.16 | $289k | | 03/15/2023 |
| 03/15/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 6k | $48.66 | $292k | | 03/15/2023 |
| 03/15/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 12k | $24.90 | $298.8k | | 03/15/2023 |
| 03/02/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Grant | Stock Option (Right to Buy) | 48k | $52.97 | $2.5M | | 03/02/2023 |
| 01/03/2023 | Coya Therapeutics, Inc. | | Purchase | Common Stock, par value $0.0001 per share | 2k | $0.00 | $0 | | 01/03/2023 |
| 01/03/2023 | Coya Therapeutics, Inc. | | Purchase | Warrant to Purchase Common Stock | 1000 | $7.50 | $7.5k | | 01/03/2023 |
| 12/01/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 4k | $62.51 | $250k | | 12/01/2022 |
| 12/01/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 4k | $24.90 | $99.6k | | 12/01/2022 |
| 10/03/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 4k | $60.90 | $243.6k | | 10/03/2022 |
| 10/03/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 4k | $24.90 | $99.6k | | 10/03/2022 |
| 09/15/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 4k | $30.00 | $120k | | 09/15/2022 |
| 09/15/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 4k | $24.90 | $99.6k | | 09/15/2022 |
| 08/01/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 4k | $30.52 | $122.1k | | 08/01/2022 |
| 08/01/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 4k | $24.90 | $99.6k | | 08/01/2022 |
| 07/06/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 8k | $30.00 | $240k | | 07/06/2022 |
| 07/06/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 8k | $24.90 | $199.2k | | 07/06/2022 |
| 02/23/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Grant | Stock Option (Right to Buy) | 85k | $32.45 | $2.8M | | 02/23/2022 |
| 04/05/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Grant | Stock Option (Right to Buy) | 250k | $24.90 | $6.2M | | 04/05/2021 |