| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/20/2023 | Mirati Therapeutics, Inc. | MRTX | Grant | Non Qualified Stock Option (right to buy) | 7.5k | $45.66 | $343.4k | | 01/20/2023 |
| 01/20/2023 | Mirati Therapeutics, Inc. | MRTX | Grant | Common Stock | 4.4k | $0.00 | $0 | | 01/20/2023 |
| 12/16/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 10k | $28.24 | $282.4k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 10k | $19.19 | $191.9k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 10k | $28.10 | $281k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 12k | $5.99 | $71.9k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 30k | $5.25 | $157.5k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 30k | $4.53 | $135.9k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 30k | $4.81 | $144.3k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Common Stock | 12k | $6.23 | $74.8k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 18k | $6.00 | $108k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 19k | $10.84 | $206k | | 08/22/2022 |
| 08/22/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Disposition | Stock Option (Right to Buy) | 10k | $19.69 | $196.9k | | 08/22/2022 |
| 07/08/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Exercise | Employee Stock Option (Right to Buy) | 12k | $3.93 | $47.2k | | 07/08/2022 |
| 01/14/2022 | Mirati Therapeutics, Inc. | MRTX | Grant | Common Stock | 2.5k | $0.00 | $0 | | 01/14/2022 |
| 01/14/2022 | Mirati Therapeutics, Inc. | MRTX | Grant | Non Qualified Stock Option (right to buy) | 3.7k | $124.31 | $458.5k | | 01/14/2022 |
| 01/12/2022 | LA JOLLA PHARMACEUTICAL CO | LJPC | Grant | Stock Option (Right to Buy) | 30k | $4.81 | $144.3k | | 01/12/2022 |
| 12/22/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Common Stock | 10.5k | $0.00 | $0 | | 12/21/2021 |
| 12/22/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Stock Option (Right to Buy) | 20.9k | $9.81 | $205.1k | | 12/21/2021 |
| 12/21/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Sale | Common Stock | 250 | $9.73 | $2.4k | | 12/21/2021 |
| 09/21/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Sale | Common Stock | 250 | $12.30 | $3.1k | | 09/21/2021 |
| 06/21/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Sale | Common Stock | 250 | $15.20 | $3.8k | | 06/21/2021 |
| 04/06/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Sale | Common Stock | 250 | $17.22 | $4.3k | | 04/06/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 3.5k | $210.01 | $736.1k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 3.2k | $210.81 | $671k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 4.6k | $211.94 | $966.9k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 3.4k | $212.97 | $718.2k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 44 | $213.62 | $9.4k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Sale | Common Stock | 334 | $214.75 | $71.7k | | 01/21/2021 |
| 01/21/2021 | Mirati Therapeutics, Inc. | MRTX | Exercise | Non Qualified Stock Option (right to buy) | 15k | $20.54 | $308.1k | | 01/21/2021 |
| 01/15/2021 | Mirati Therapeutics, Inc. | MRTX | Grant | Common Stock | 1.5k | $0.00 | $0 | | 01/15/2021 |
| 01/15/2021 | Mirati Therapeutics, Inc. | MRTX | Grant | Non Qualified Stock Option (right to buy) | 2.2k | $214.47 | $462.2k | | 01/15/2021 |
| 12/29/2020 | Odonate Therapeutics, Inc. | ODT | Purchase | Common Stock | 3k | $17.00 | $51k | | 12/29/2020 |
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