| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/29/2020 | MANNING MARTHA E | General Counsel | Disposition | Stock Options (Right to buy) | 110k | $6.79 | $746.9k | | 01/28/2020 |
| 01/29/2020 | MANNING MARTHA E | General Counsel | Disposition | Stock Options (Right to buy) | 135k | $4.11 | $554.8k | | 01/28/2020 |
| 01/28/2020 | Firuta Paul E | EVP, Chief Commercial Officer | Disposition | Stock Options (Right to buy) | 400k | $3.32 | $1.3M | | 01/28/2020 |
| 01/28/2020 | Firuta Paul E | EVP, Chief Commercial Officer | Disposition | Stock Options (Right to buy) | 200k | $2.18 | $436k | | 01/28/2020 |
| 01/28/2020 | Gibney Anthony S | EVP, Chief Business Officer | Disposition | Stock Options (Right to buy) | 500k | $2.53 | $1.3M | | 01/28/2020 |
| 01/28/2020 | Gibney Anthony S | EVP, Chief Business Officer | Disposition | Stock Options (Right to buy) | 200k | $2.18 | $436k | | 01/28/2020 |
| 01/28/2020 | Di Donato Brian | SVP, CFO | Disposition | Stock Options (Right to buy) | 200k | $2.56 | $512k | | 01/28/2020 |
| 01/28/2020 | Di Donato Brian | SVP, CFO | Disposition | Stock Options (Right to buy) | 500k | $2.29 | $1.1M | | 01/28/2020 |
| 01/28/2020 | Verwiel Frank | Director | Disposition | Stock Options (Right to buy) | 30k | $7.54 | $226.2k | | 01/28/2020 |
| 01/28/2020 | Verwiel Frank | Director | Disposition | Stock Options (Right to buy) | 30k | $4.09 | $122.7k | | 01/28/2020 |
| 01/28/2020 | Verwiel Frank | Director | Disposition | Stock Options (Right to buy) | 30k | $2.90 | $87k | | 01/28/2020 |
| 01/28/2020 | Verwiel Frank | Director | Disposition | Stock Options (Right to buy) | 42k | $2.18 | $91.6k | | 01/28/2020 |
| 01/28/2020 | Zelenkofske Steven | EVP, Chief Medical Officer | Disposition | Stock Options (Right to buy) | 500k | $2.49 | $1.2M | | 01/28/2020 |
| 01/28/2020 | Zelenkofske Steven | EVP, Chief Medical Officer | Disposition | Stock Options (Right to buy) | 200k | $2.18 | $436k | | 01/28/2020 |
| 01/28/2020 | MANNING MARTHA E | General Counsel | Disposition | Common Stock | 2.5k | $6.30 | $15.8k | | 01/28/2020 |
| 01/28/2020 | MANNING MARTHA E | General Counsel | Disposition | Stock Options (Right to buy) | 215k | $2.90 | $623.5k | | 01/28/2020 |
| 01/28/2020 | MANNING MARTHA E | General Counsel | Disposition | Stock Options (Right to buy) | 150k | $2.18 | $327k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Common Stock | 22.7k | $6.30 | $143.1k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 30k | $7.54 | $226.2k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 135k | $6.12 | $826.2k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 30k | $4.09 | $122.7k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 25k | $3.02 | $75.5k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 30k | $2.90 | $87k | | 01/28/2020 |
| 01/28/2020 | Graves Kurt | Director | Disposition | Stock Options (Right to buy) | 42k | $2.18 | $91.6k | | 01/28/2020 |
| 01/28/2020 | G1 EXECUTION SERVICES, LLC | 10% Owner | Other (disposition) | Common Stock | 10.9k | $6.30 | $68.8k | | 01/28/2020 |
| 01/28/2020 | G1 EXECUTION SERVICES, LLC | 10% Owner | Other (disposition) | Common Stock | 14.1M | $6.30 | $88.9M | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Common Stock | 3.5k | $6.30 | $22k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 142k | $7.61 | $1.1M | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 100k | $7.59 | $759k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 185k | $4.11 | $760.4k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 632k | $3.78 | $2.4M | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 30k | $3.66 | $109.8k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 87.8k | $3.10 | $272.1k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 200k | $3.02 | $604k | | 01/28/2020 |
| 01/28/2020 | Truitt Joseph | CEO | Disposition | Stock Options (Right to buy) | 419k | $2.90 | $1.2M | | 01/28/2020 |
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