Type	Name	Date
Underwriting agreement	Underwriting Agreement	01/23/2020
Underwriting agreement	Underwriting Agreement, among Blueprint Medicines Corporation and Goldman Sachs & Co. LLC and Cowen and Company, LLC, as representatives of the underwriters named therein	03/29/2019
Underwriting agreement	Underwriting Agreement, among Blueprint Medicines Corporation and Goldman Sachs & Co. LLC and Morgan Stanley & Co. LLC, as representatives of the underwriters named therein	12/13/2017
Underwriting agreement	Underwriting Agreement, among Blueprint Medicines Corporation and Goldman, Sachs & Co. and Morgan Stanley & Co. LLC, as representatives of the underwriters named therein	03/30/2017
Underwriting agreement	Underwriting Agreement, among Blueprint Medicines Corporation and Goldman, Sachs & Co. and Morgan Stanley & Co. LLC, as representatives of the underwriters named therein	12/08/2016

Type	Name	Date
Employment agreement	Amended and Restated Employment Agreement, by and between the Registrant and Becker Hewes, M.D	01/11/2021
Employment agreement	Employment Agreement, by and between Blueprint Medicines Corporation and Michael Landsittel	11/22/2017
Employment agreement	Employment Agreement, by and between Blueprint Medicines Corporation and Marion Dorsch	11/14/2016

Type	Name	Date
Lease agreement	First Amendment of Lease, between Blueprint Medicines Corporation and UP 45/75 Sidney Street, LLC	09/25/2018