| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/08/2023 | MARINUS PHARMACEUTICALS, INC. | MRNS | Sale | Common Stock | 30 | $8.94 | $268.2 | | 08/07/2023 |
| 08/07/2023 | MARINUS PHARMACEUTICALS, INC. | MRNS | Sale | Common Stock | 6.4k | $9.55 | $61.2k | | 08/07/2023 |
| 02/21/2023 | Caribou Biosciences, Inc. | CRBU | Grant | Option to purchase Common Stock | 21.5k | $6.12 | $131.6k | | 02/21/2023 |
| 01/26/2023 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Common Stock | 80k | $0.00 | $0 | | 01/26/2023 |
| 01/26/2023 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock Option (Right to Buy) | 360k | $5.94 | $2.1M | | 01/26/2023 |
| 06/09/2022 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 05/24/2022 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Common Stock | 19.3k | $0.00 | $0 | | 05/24/2022 |
| 02/04/2022 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Common Stock | 42.9k | $0.00 | $0 | | 02/04/2022 |
| 02/04/2022 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock Option (Right to Buy) | 193k | $10.40 | $2M | | 02/04/2022 |
| 12/20/2021 | Caribou Biosciences, Inc. | CRBU | Grant | Option to purchase Common Stock | 27.5k | $15.16 | $416.9k | | 12/20/2021 |
| 07/15/2021 | CONSTELLATION PHARMACEUTICALS INC | CNST | Disposition | Stock Option (Right to Buy) | 13.2k | $33.57 | $442.2k | | 07/15/2021 |
| 07/15/2021 | CONSTELLATION PHARMACEUTICALS INC | CNST | Disposition | Stock Option (right to buy) | 26.3k | $10.81 | $284.8k | | 07/15/2021 |
| 07/15/2021 | CONSTELLATION PHARMACEUTICALS INC | CNST | Disposition | Stock Options (Right to buy) | 13.2k | $37.52 | $494.2k | | 07/15/2021 |
| 06/02/2021 | CONSTELLATION PHARMACEUTICALS INC | CNST | Grant | Stock Option (Right to Buy) | 13.2k | $33.57 | $442.2k | | 06/02/2021 |
| 05/28/2021 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 68.6k | $1.74 | $119.3k | | 05/28/2021 |
| 01/15/2021 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock option (right to buy) | 290k | $12.60 | $3.7M | | 01/15/2021 |
| 06/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 9k | $35.00 | $315k | | 06/09/2020 |
| 06/04/2020 | CONSTELLATION PHARMACEUTICALS INC | CNST | Grant | Stock Options (Right to buy) | 13.2k | $37.52 | $494.2k | | 06/04/2020 |
| 05/13/2020 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 64.1k | $1.05 | $67.3k | | 05/13/2020 |
| 01/10/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Common Stock | 26.5k | $0.00 | $0 | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 9.5k | $9.18 | $87.5k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 2.9k | $9.18 | $26.3k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 6.7k | $9.18 | $61.3k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 15.7k | $9.18 | $144.5k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 2.9k | $9.18 | $26.3k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 16.2k | $9.18 | $148.8k | | 01/09/2020 |
| 01/09/2020 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 15.6k | $9.18 | $143.6k | | 01/09/2020 |
| 01/08/2020 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock option (right to buy) | 1.8M | $2.07 | $3.7M | | 01/08/2020 |
| 12/31/2019 | Alaunos Therapeutics, Inc. | ZIOP | Grant | Common Stock | 31.8k | $0.00 | $0 | | 12/31/2019 |
| 12/13/2019 | MARINUS PHARMACEUTICALS, INC. | MRNS | Purchase | Common stock | 100k | $1.25 | $125k | | 12/13/2019 |
| 08/06/2019 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock option (right to buy) | 1000k | $1.07 | $1.1M | | 08/06/2019 |
| 05/29/2019 | Esperion Therapeutics, Inc. | ESPR | Grant | Common Stock | 5k | $0.00 | $0 | | 05/29/2019 |
| 05/16/2019 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 30k | $1.34 | $40.2k | | 05/16/2019 |
| 02/26/2019 | MARINUS PHARMACEUTICALS, INC. | MRNS | Grant | Stock option (right to buy) | 240k | $3.96 | $950.4k | | 02/26/2019 |
| 02/19/2019 | CONSTELLATION PHARMACEUTICALS INC | CNST | Grant | Stock Option (right to buy) | 26.3k | $10.81 | $284.8k | | 02/19/2019 |
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