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COLUMBIA PARTNERS L L C INVESTMENT MANAGEMENT
> SHPG
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2018 | Shire plc | SHPG | 30,203 | 0 | 5,256,000 | -218,000 | $174.02 |
| 09/30/2018 | Shire plc | SHPG | 30,203 | 0 | 5,474,000 | 376,000 | $181.24 |
| 06/30/2018 | Shire plc | SHPG | 30,203 | 8,495 | 5,098,000 | 1,856,000 | $168.79 |
| 03/31/2018 | Shire plc | SHPG | 21,708 | -9,303 | 3,242,000 | -1,568,000 | $149.35 |
| 12/31/2017 | Shire plc | SHPG | 31,011 | 0 | 4,810,000 | 61,000 | $155.11 |
| 09/30/2017 | Shire plc | SHPG | 31,011 | 0 | 4,749,000 | -376,000 | $153.14 |
| 06/30/2017 | Shire plc | SHPG | 31,011 | 0 | 5,125,000 | -278,000 | $165.26 |
| 03/31/2017 | Shire plc | SHPG | 31,011 | 0 | 5,403,000 | 120,000 | $174.23 |
| 12/31/2016 | Shire plc | SHPG | 31,011 | -100 | 5,283,000 | -748,000 | $170.36 |
| 09/30/2016 | Shire plc | SHPG | 31,111 | 0 | 6,031,000 | 305,000 | $193.85 |
| 06/30/2016 | Shire plc | SHPG | 31,111 | 0 | 5,726,000 | -651,000 | $184.05 |
| 03/31/2016 | Shire plc | SHPG | 31,111 | 0 | 5,347,000 | -1,030,000 | $171.87 |
| 12/31/2015 | Shire plc | SHPG | 31,111 | 16,264 | 6,377,000 | 4,965,000 | $204.98 |
| 09/30/2015 | Shire plc | SHPG | 31,111 | 0 | 6,384,000 | -1,128,000 | $205.20 |
| 06/30/2015 | Shire plc | SHPG | 31,111 | -14,770 | 7,512,000 | 2,012,000 | $241.46 |
| 03/31/2015 | Shire plc | SHPG | 31,111 | 0 | 7,444,000 | 832,000 | $239.27 |
| 12/31/2014 | Shire plc | SHPG | 18,047 | -27,834 | 1,648,000 | -3,852,000 | $91.32 |
| 09/30/2014 | Shire plc | SHPG | 31,111 | 0 | 8,059,000 | 733,000 | $259.04 |
| 06/30/2014 | Shire plc | SHPG | 31,111 | -14,770 | 7,326,000 | 1,826,000 | $235.48 |
| 03/31/2014 | Shire plc | SHPG | 45,881 | 0 | 6,814,000 | 1,314,000 | $148.51 |
| 12/31/2013 | Shire plc | SHPG | 45,881 | 0 | 6,482,000 | 982,000 | $141.28 |
| 09/30/2013 | Shire plc | SHPG | 45,881 | 31,034 | 5,500,000 | 4,088,000 | $119.88 |
| 06/30/2013 | Shire plc | SHPG | 14,847 | -17,363 | 1,412,000 | -1,557,000 | $95.10 |
| 03/31/2013 | Shire plc | SHPG | 18,047 | -14,163 | 1,648,000 | -1,321,000 | $91.32 |
| 12/31/2012 | Shire plc | SHPG | 32,210 | 0 | 2,969,000 | 112,000 | $92.18 |
| 09/30/2012 | Shire plc | SHPG | 32,210 | 22,377 | 2,857,000 | 2,008,000 | $88.70 |
| 06/30/2012 | Shire plc | SHPG | 9,833 | -73,303 | 849,000 | -7,789,000 | $86.34 |
| 03/31/2012 | Shire plc | SHPG | 92,202 | 9,066 | 8,736,000 | 98,000 | $94.75 |
| 12/31/2011 | Shire plc | SHPG | 83,136 | -615 | 8,638,000 | 771,000 | $103.90 |
| 09/30/2011 | Shire plc | SHPG | 83,751 | -2,173 | 7,867,000 | -228,000 | $93.93 |
| 06/30/2011 | Shire plc | SHPG | 85,924 | -1,854 | 8,095,000 | 456,000 | $94.21 |
| 03/31/2011 | Shire plc | SHPG | 87,778 | -4,355 | 7,639,000 | 1,440,000 | $87.03 |
| 12/31/2010 | Shire plc | SHPG | 89,720 | -2,413 | 6,494,000 | 295,000 | $72.38 |
| 09/30/2010 | Shire plc | SHPG | 92,133 | -3,127 | 6,199,000 | 352,000 | $67.28 |
| 06/30/2010 | Shire plc | SHPG | 95,260 | -750 | 5,847,000 | -491,000 | $61.38 |
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