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Swiss National Bank
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 930,300 | -88,500 | 327,381,873,000 | 6,388,557,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,018,800 | -23,600 | 320,993,316,000 | 19,969,044,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,042,400 | -65,975 | 301,024,272,000 | 300,703,353,000 | $288,780.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,108,375 | 4,100 | 320,919,000 | 9,745,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,104,275 | 3,100 | 311,174,000 | 23,800,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,101,175 | 115,100 | 287,374,000 | 70,832,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 986,075 | -37,600 | 216,542,000 | 30,858,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,023,675 | -36,300 | 185,684,000 | -28,039,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,059,975 | -429,000 | 213,723,000 | -106,243,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,488,975 | 21,500 | 319,966,000 | -26,857,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,467,475 | 77,300 | 346,823,000 | -31,471,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,390,175 | 204,400 | 378,294,000 | 34,052,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,185,775 | 149,700 | 344,242,000 | 97,708,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,036,075 | 205,900 | 246,534,000 | 64,767,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 830,175 | -34,800 | 181,767,000 | 35,223,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 864,975 | 10,866 | 146,544,000 | -10,083,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 854,109 | 1,200 | 156,627,000 | -266,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 852,909 | 22,000 | 156,893,000 | 19,203,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 830,909 | 17,400 | 137,690,000 | -19,106,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 813,509 | -25,300 | 156,796,000 | 14,232,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 838,809 | 27,400 | 142,564,000 | 10,321,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 811,409 | -117,600 | 132,243,000 | -6,978,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 929,009 | 10,800 | 139,221,000 | -383,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 918,209 | 11,100 | 139,604,000 | 22,705,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 907,109 | 28,300 | 116,899,000 | 20,801,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 878,809 | 878,809 | 96,098,000 | 96,098,000 | $109.35 |
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