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CITADEL ADVISORS LLC
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 3,149,682 | -563,471 | 5,637,931,000 | -6,659,236,000 | $1,790.00 |
| 12/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 3,713,153 | 1,903,507 | 12,297,167,000 | 12,287,286,000 | $3,311.79 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 1,809,646 | 1,401,297 | 9,881,000 | 8,039,000 | $5.46 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 408,349 | -446,168 | 1,842,000 | -4,456,000 | $4.51 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 854,517 | 625,634 | 6,298,000 | 4,826,000 | $7.37 |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 228,883 | 8,106 | 1,472,000 | 187,000 | $6.43 |
| 09/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 220,777 | 9,683 | 1,285,000 | -893,000 | $5.82 |
| 06/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 211,094 | -611,422 | 2,178,000 | -6,474,000 | $10.32 |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 822,516 | 545,441 | 8,652,000 | 4,363,000 | $10.52 |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 277,075 | -650,363 | 4,289,000 | -9,252,000 | $15.48 |
| 09/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 927,438 | 788,306 | 13,541,000 | 10,906,000 | $14.60 |
| 06/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 139,132 | -1,367,171 | 2,635,000 | -26,301,000 | $18.94 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 1,506,303 | 113,309 | 28,936,000 | 2,232,000 | $19.21 |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 1,392,994 | -137,595 | 26,704,000 | 11,980,000 | $19.17 |
| 09/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 1,530,589 | 649,656 | 14,724,000 | 9,447,000 | $9.62 |
| 06/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 880,933 | -911,471 | 5,277,000 | -5,191,000 | $5.99 |
| 03/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 1,792,404 | 1,540,334 | 10,468,000 | 8,106,000 | $5.84 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 252,070 | 10,953 | 2,362,000 | -1,745,000 | $9.37 |
| 09/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 241,117 | 64,755 | 4,107,000 | 1,111,000 | $17.03 |
| 06/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 176,362 | 82,422 | 2,996,000 | 1,735,000 | $16.99 |
| 03/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 93,940 | 39,632 | 1,261,000 | 740,000 | $13.42 |
| 12/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 54,308 | 34,278 | 521,000 | 301,000 | $9.59 |
| 09/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 20,030 | -41,107 | 220,000 | -333,000 | $10.98 |
| 06/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 61,137 | -18,592 | 553,000 | -471,000 | $9.05 |
| 03/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 79,729 | 33,745 | 1,024,000 | 592,000 | $12.84 |
| 12/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 45,984 | 16,631 | 432,000 | 146,000 | $9.39 |
| 09/30/2016 | Karyopharm Therapeutics Inc. | KPTI | 29,353 | 29,353 | 286,000 | 286,000 | $9.74 |
| 03/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 0 | -22,859 | 0 | -303,000 | |
| 12/31/2015 | Karyopharm Therapeutics Inc. | KPTI | 22,859 | 22,859 | 303,000 | 303,000 | $13.26 |
| 09/30/2015 | Karyopharm Therapeutics Inc. | KPTI | 0 | -453,249 | 0 | -12,333,000 | |
| 06/30/2015 | Karyopharm Therapeutics Inc. | KPTI | 453,249 | 427,786 | 12,333,000 | 11,554,000 | $27.21 |
| 03/31/2015 | Karyopharm Therapeutics Inc. | KPTI | 25,463 | 25,182 | 779,000 | 768,000 | $30.59 |
| 12/31/2014 | Karyopharm Therapeutics Inc. | KPTI | 281 | 281 | 11,000 | 11,000 | $39.15 |
| 09/30/2014 | Karyopharm Therapeutics Inc. | KPTI | 0 | -78,900 | 0 | -3,673,000 | |
| 06/30/2014 | Karyopharm Therapeutics Inc. | KPTI | 78,900 | 78,900 | 3,673,000 | 3,673,000 | $46.55 |
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