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BAKER BROS ADVISORS LLC

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Changes: All | New | Increased | Decreased | Sold Out Portfolio as of:
NameTickerClassSharesChangeValueChange% Port% OSHistDate
PHARMACYCLICS INC PCYCCommon11,444,3600661,255,000-76,906,00017.29  Hist 12/31/2012
SEATTLE GENETICS INC /WA SGENCOM19,322,9470447,712,000-72,848,00011.7116.35 Hist 12/31/2012
TRIMERIS INC GEVACommon8,363,462-1387,145,000-59,715,00010.13  Hist 12/31/2012
GENOMIC HEALTH INC GHDXCOM12,699,5841,495,996355,588,352-33,063,648   Hist 02/08/2013
INCYTE CORP INCYCommon14,810,5590246,003,000-21,328,0006.4311.29 Hist 12/31/2012
VIROPHARMA INC VPHMCommon9,025,270-1,860,608205,415,000-123,230,0005.37  Hist 12/31/2012
AUXILIUM PHARMACEUTICALS INC AUXLCOM4,371,129-1,883,32881,038,000-71,946,0002.12  Hist 12/31/2012
ACADIA PHARMACEUTICALS INC ACADCommon15,621,81210,375,50072,641,00059,368,0001.90  Hist 12/31/2012
BIOMARIN PHARMACEUTICAL INC  Common22,898,000056,577,0008,880,0001.4818.49 Hist 12/31/2012
REPROS THERAPEUTICS INC. RPRXCommon Stock2,778,6541,280,56553,100,07829,505,078   Hist 07/01/2013
MEDIVATION, INC. MDVNCommon966,546049,448,000-5,017,0001.291.30 Hist 12/31/2012
XOMA LTD /DE/  Common20,274,5814,722,66648,659,000-8,728,0001.27  Hist 12/31/2012
ARIAD PHARMACEUTICALS INC ARIACommon2,129,070-3,445,74940,836,000-94,130,0001.07  Hist 12/31/2012
CERUS CORP CERSCommon Stock8,455,3066,345,79437,795,21831,129,218   Hist 07/01/2013
Clovis Oncology, Inc.  Common1,115,182-507,44817,843,000-15,340,0000.474.27 Hist 12/31/2012
INTERMUNE INC ITMNCommon1,759,926891,74517,054,0009,275,0000.452.68 Hist 12/31/2012
SPECTRUM PHARMACEUTICALS INC SPPICOM1,500,000-1,820,36016,779,000-22,069,0000.44  Hist 12/31/2012
Aegerion Pharmaceuticals, Inc. AEGRCommon614,485015,595,0006,488,0000.412.41 Hist 12/31/2012
DERMA SCIENCES, INC. DSCICOM1,358,857150,00015,097,0002,549,0000.39  Hist 12/31/2012
SYNTA PHARMACEUTICALS CORP SNTACOMMON1,462,614150,14313,193,0003,192,0000.35  Hist 12/31/2012
ONYX PHARMACEUTICALS INC ONXXCommon159,652-54,89112,059,000-6,070,0000.320.24 Hist 12/31/2012
HALOZYME THERAPEUTICS INC HALOCOM1,769,776-12,45211,875,000-1,563,0000.311.57 Hist 12/31/2012
QLT INC/BC QLTICommon1,460,663510,72611,481,0004,081,0000.302.82 Hist 12/31/2012
BIOMARIN PHARMACEUTICAL INC BMRNCommon200,43209,861,0001,792,0000.260.16 Hist 12/31/2012
BIODELIVERY SCIENCES INTERNATIONAL INC BDSICOM2,139,42609,221,000-4,300,0000.24  Hist 12/31/2012
XENOPORT INC XNPTCommon1,034,11208,035,000-3,807,0000.212.41 Hist 12/31/2012
BIOCRYST PHARMACEUTICALS INC BCRXCommon5,563,61507,901,000-15,689,0000.2110.93 Hist 12/31/2012
GILEAD SCIENCES INC GILDCommon91,900-648,4006,750,000-42,354,0000.18  Hist 12/31/2012
THRESHOLD PHARMACEUTICALS INC  Common1,595,04870,0006,715,000-4,326,0000.182.84 Hist 12/31/2012
ARRAY BIOPHARMA INC ARRYCommon1,500,000500,0005,580,000-265,0000.151.57 Hist 12/31/2012
Anacor Pharmaceuticals Inc ANACCOM776,463208,3334,038,000300,0000.112.46 Hist 12/31/2012
ARQULE INC ARQLCOM1,294,4671,208,3003,612,0003,172,0000.09  Hist 12/31/2012
SALIX PHARMACEUTICALS LTD SLXPCommon66,53666,5362,693,0002,693,0000.070.11 Hist 12/31/2012
PROGENICS PHARMACEUTICALS INC PGNXCommon900,000900,0002,682,0002,682,0000.07  Hist 12/31/2012
ZOGENIX, INC. ZGNXCommon2,001,00002,661,000-2,622,0000.07  Hist 12/31/2012
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