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Tekla Capital Management LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 318,043 | -12,300 | 111,922,512,000 | 7,841,343,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 330,343 | 16,940 | 104,081,169,000 | 103,990,426,000 | $315,070.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 313,403 | -47,828 | 90,743,000 | -11,048,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 361,231 | 52,347 | 101,791,000 | 21,182,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 308,884 | 35,838 | 80,609,000 | 20,648,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 273,046 | 0 | 59,961,000 | 10,433,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 273,046 | -122,242 | 49,528,000 | -30,174,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 395,288 | 0 | 79,702,000 | -5,241,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 395,288 | 89,978 | 84,943,000 | 12,786,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 305,310 | -96,050 | 72,157,000 | -37,061,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 401,360 | -75,970 | 109,218,000 | -29,356,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 477,330 | -8,400 | 138,574,000 | 22,995,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 485,730 | -8,059 | 115,579,000 | 7,464,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 493,789 | 6,555 | 108,115,000 | 25,568,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 487,234 | -2,500 | 82,547,000 | -7,260,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 489,734 | 46,022 | 89,807,000 | 8,186,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 443,712 | 17,464 | 81,621,000 | 10,987,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 426,248 | 18,013 | 70,634,000 | -8,049,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 408,235 | -173,287 | 78,683,000 | -20,152,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 581,522 | -32,562 | 98,835,000 | -1,248,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 614,084 | -29,678 | 100,083,000 | 3,609,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 643,762 | -87,361 | 96,474,000 | -14,686,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 731,123 | -66,930 | 111,160,000 | 8,315,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 798,053 | -235,450 | 102,845,000 | -10,169,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 0 | 113,014,000 | 36,876,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 0 | 76,138,000 | -13,994,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 0 | 90,132,000 | -39,914,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 0 | 88,902,000 | 6,749,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 0 | 82,153,000 | -47,893,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,033,503 | 331,559 | 130,046,000 | 51,211,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,009,903 | 307,959 | 105,171,000 | 26,336,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 897,903 | 195,959 | 110,873,000 | 32,038,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 464,244 | -237,700 | 54,767,000 | -24,068,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 701,944 | 0 | 83,391,000 | 4,556,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 701,944 | 701,944 | 78,835,000 | 78,835,000 | $112.31 |
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