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Palo Alto Investors LP
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 5,675,876 | 0 | 10,159,818,000 | -11,919,340,000 | $1,790.00 |
| 03/31/2023 | Karyopharm Therapeutics Inc. | KPTI | 5,675,876 | 20,200 | 22,079,158,000 | 2,849,860,000 | $3,890.00 |
| 12/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 5,655,676 | 34,143 | 19,229,298,000 | 19,198,604,000 | $3,400.00 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 5,621,533 | 0 | 30,694,000 | 5,341,000 | $5.46 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 5,621,533 | 0 | 25,353,000 | -16,078,000 | $4.51 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 5,621,533 | 151,081 | 41,431,000 | 6,256,000 | $7.37 |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 5,470,452 | 87,400 | 35,175,000 | 3,846,000 | $6.43 |
| 09/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 5,383,052 | 0 | 31,329,000 | -24,224,000 | $5.82 |
| 06/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 5,383,052 | 19,400 | 55,553,000 | -873,000 | $10.32 |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 5,363,652 | 96,000 | 56,426,000 | -25,117,000 | $10.52 |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 5,267,652 | 181,500 | 81,543,253 | 7,285,253 | $15.48 |
| 09/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 5,086,152 | 866,700 | 74,258,000 | -5,658,000 | $14.60 |
| 06/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 4,219,452 | -80,449 | 79,916,000 | -2,685,000 | $18.94 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 4,299,901 | -295,100 | 82,601,000 | -5,485,000 | $19.21 |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 4,595,001 | -247,149 | 88,086,000 | 41,505,000 | $19.17 |
| 09/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 4,842,150 | -420,113 | 46,581,000 | 15,060,000 | $9.62 |
| 06/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 5,262,263 | 0 | 31,521,000 | 789,000 | $5.99 |
| 03/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 5,262,263 | 576,911 | 30,732,000 | -13,170,000 | $5.84 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 4,685,352 | 22,028 | 43,902,000 | -35,514,000 | $9.37 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 4,685,352 | 22,028 | 43,901,748 | -35,514,252 | $9.37 |
| 09/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 4,663,324 | 0 | 79,416,000 | 186,000 | $17.03 |
| 06/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 4,663,324 | 983,346 | 79,230,000 | 29,845,000 | $16.99 |
| 03/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 3,679,978 | 135,539 | 49,385,000 | 15,358,000 | $13.42 |
| 12/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 3,544,439 | 45,854 | 34,026,614 | -4,387,386 | $9.60 |
| 09/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 3,498,585 | 31,010 | 38,414,000 | 7,032,000 | $10.98 |
| 06/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 3,467,575 | 61,100 | 31,382,000 | -12,357,000 | $9.05 |
| 03/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 3,406,475 | 206,079 | 43,739,000 | 13,655,000 | $12.84 |
| 12/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 3,200,396 | 114,547 | 30,084,000 | 59,000 | $9.40 |
| 09/30/2016 | Karyopharm Therapeutics Inc. | KPTI | 3,085,849 | -53,584 | 30,025,000 | 8,959,000 | $9.73 |
| 06/30/2016 | Karyopharm Therapeutics Inc. | KPTI | 3,139,433 | 3,139,433 | 21,066,000 | 21,066,000 | $6.71 |
| 03/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 3,098,145 | -14,500 | 27,635,000 | -13,608,000 | $8.92 |
| 12/31/2015 | Karyopharm Therapeutics Inc. | KPTI | 3,112,645 | 3,112,645 | 41,243,000 | 41,243,000 | $13.25 |
| 09/30/2015 | Karyopharm Therapeutics Inc. | KPTI | 3,085,745 | 3,085,745 | 32,493,000 | 32,493,000 | $10.53 |
| 06/30/2015 | Karyopharm Therapeutics Inc. | KPTI | 1,731,530 | 1,731,530 | 47,115,000 | 47,115,000 | $27.21 |
| 03/31/2015 | Karyopharm Therapeutics Inc. | KPTI | 951,032 | 951,032 | 29,111,000 | 29,111,000 | $30.61 |
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